Review
Biochemistry & Molecular Biology
Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, Sergei B. Seredenin
Summary: Modern pharmacotherapy of neurodegenerative diseases is primarily symptomatic and ineffective in halting disease progression. Protein misfolding is regarded as a crucial pathogenic factor in these diseases. Chaperones and endoplasmic reticulum stress mechanisms show promise in regulating these processes. This review provides an analysis of the role of BiP and Sigma1R chaperones in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, and highlights the neuroprotective effect of Sigma1R ligand activation. The interaction between Sigma1R and BiP-associated signaling is also discussed, emphasizing the need for further study in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Mahmoud S. Alghamri, Brandon L. McClellan, Margaret S. Hartlage, Santiago Haase, Syed Mohd Faisal, Rohit Thalla, Ali Dabaja, Kaushik Banerjee, Stephen V. Carney, Anzar A. Mujeeb, Michael R. Olin, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
Summary: Gliomas, particularly glioblastomas, are highly aggressive and lethal cancers with unique molecular characteristics and genetic signatures. The interactions between tumor cells and immune cells in the tumor microenvironment play a critical role in glioma progression. Understanding the impact of inflammation and potential pharmacological interventions targeting neuro-inflammation are important for improving outcomes in glioma patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ahmad Karami, Sajad Fakhri, Leila Kooshki, Haroon Khan
Summary: Polydatin is a natural polyphenol compound that possesses various important biological activities, such as anticancer and cardioprotective effects. This study reviews the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin, and suggests the need for further clinical trials and novel delivery systems.
Article
Biochemistry & Molecular Biology
Fangfei Liu, Lampson M. Fan, Li Geng, Jian-Mei Li
Summary: The p47(phox) plays a crucial role in AngII-induced cardiac hypertrophy and cardiomyocyte apoptosis by regulating redox-signalling pathways through ASK1, MKK3/6 and MAPKs.
Article
Cell Biology
Jenaro Antonio Espitia-Corredor, Pia Boza, Claudio Espinoza-Perez, Jose Miguel Lillo, Constanza Rimassa-Tare, Victor Machuca, Jose Miguel Osorio-Sandoval, Raul Vivar, Samir Bolivar, Viviana Pardo-Jimenez, Carlos Felix Sanchez-Ferrer, Concepcion Peiro, Guillermo Diaz-Araya
Summary: In cardiac fibroblasts, angiotensin II triggers assembly and activation of the NLRP3 inflammasome through a calcium-dependent mechanism, leading to the secretion of IL-1β.
Review
Cell Biology
Jing Yang, Qiu-yi Song, Shu-xuan Niu, Hui-jing Chen, Robert B. Petersen, Yu Zhang, Kun Huang
Summary: ANGPTLs, a family of secreted glycoproteins, play key roles in lipid metabolism and inflammation. Their potential roles and mechanisms in inflammatory diseases have attracted significant attention from researchers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Yongbiao Huang, Ye Yuan, Sheng Chen, Duo Xu, Lingyan Xiao, Xi Wang, Wan Qin, Bo Liu
Summary: This study aimed to investigate the therapeutic effects and underlying action mechanisms of vitamin D in COVID-19 and HCC. Through bioinformatics and network pharmacology analyses, we identified target genes and analyzed their prognostic significance in HCC patients. We developed a risk score model to evaluate the prognosis of HCC patients with COVID-19 and identified seven potential pharmacological targets of vitamin D. We also revealed the biological functions, signaling pathways, and TF-miRNA coregulatory network of vitamin D in COVID-19/HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chang-Bo Zheng, Wen-Cong Gao, Mingxu Xie, Zhichao Li, Xin Ma, Wencong Song, Dan Luo, Yongxiang Huang, Jichen Yang, Peng Zhang, Yu Huang, Weimin Yang, Xiaoqiang Yao
Summary: This study demonstrates that Ang II promotes excessive cardiomyocyte autophagy through SOCE/Orai1, which are major contributing factors in cardiac hypertrophy. Inhibition of SOCE or silencing of Orai1 attenuated Ang II-induced cardiomyocyte autophagy and pathological cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wei Liu, Zining Tan, Mengrou Geng, Xin Jiang, Ying Xin
Summary: This article discusses the relationship between the renin-angiotensin system (RAS) and the gut microbiota, noting that Angiotensin II (Ang II) can lead to an imbalance in the gut microbiota, thereby exacerbating disease progression. In addition, angiotensin converting enzyme 2 can alleviate the deleterious effects of Ang II and regulate gut microbial dysbiosis and immune responses associated with coronavirus disease 19. Deciphering these mechanisms will provide a theoretical basis for novel therapeutic strategies for disease prevention and treatment. Finally, therapies targeting the gut microbiota to treat Ang II-related disorders are discussed.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Allen Sam Titus, Harikrishnan Venugopal, Mereena George Ushakumary, Mingyi Wang, Randy T. Cowling, Edward G. Lakatta, Shivakumar Kailasam
Summary: The study revealed the crucial role of fibronectin in regulating cardiac fibroblast function, mediated by DDR2 and Integrin-beta 1 signaling pathways. This complex mechanism involves collagen type I and fibronectin interacting with their receptors, offering insights into potential therapeutic targets for myocardial injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rui Zhang, Yangyang Qu, Zhenjun Ji, Chunshu Hao, Yamin Su, Yuyu Yao, Wenjie Zuo, Xi Chen, Mingming Yang, Genshan Ma
Summary: METTL3 plays a significant role in Ang-II-induced myocardial hypertrophy by modulating miR-221/222 and activating Wnt/β-catenin signaling.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Plant Sciences
Chengyi Dai, Wu Luo, Yanghao Chen, Siyuan Shen, Zhe Wang, Ruijie Chen, Jun Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang
Summary: This study found that Tab protects the heart from Ang II-induced injuries by targeting TAK1 and inhibiting TAK1-mediated inflammatory cascade and response. The protective effects of Tab were observed in both mouse models and in vitro experiments, showing reduced cardiac inflammation and fibrosis. These findings suggest that Tab may be a potential therapeutic candidate for hypertensive heart failure.
Review
Biochemistry & Molecular Biology
Maartje Westhoff, Rose E. Dixon
Summary: During cardiac excitation-contraction coupling, the activity of Ca(V)1.2 channels plays a crucial role in regulating calcium influx, intracellular calcium concentration, and ultimately myocardial contraction. Recent studies have identified internal reservoirs of preformed Ca(V)1.2 channels that can be rapidly mobilized during acute stress to enhance sarcolemmal expression and maintain cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku
Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Gabriel Mendez-Valdes, Vicente Perez-Carreno, Maria Chiara Bragato, Malthe Hundahl, Silvia Chichiarelli, Luciano Saso, Ramon Rodrigo
Summary: Ischemia/reperfusion injury is a detrimental process during cardiac interventions, leading to activation of cell death pathways and increased cardiovascular risk. Multiple NADPH oxidases, activated via AT1R occupancy, contribute to the generation of ROS. In addition, ROS can induce proinflammatory responses. On the other hand, the Ang II/AT2R axis exerts cardioprotective effects. AT1R blockers may be used to inhibit the Ang II/AT1R axis and reduce ROS burst, while combination with other cardioprotective agents shows promising outcomes in experimental studies.