Article
Oncology
Shuying Chen, Yinqi Mao, Wei Chen, Chenbin Liu, Han Wu, Jingjun Zhang, Shenghao Wang, Chengpan Wang, Yong Lin, Yuan Lv
Summary: This study found that serum exosomal miR-34a is significantly down-regulated in patients with hepatocellular carcinoma (HCC), and it may serve as a novel non-invasive biomarker for the diagnosis and prognosis of HCC.
Review
Oncology
Ying Zhao, Jinmei Yao
Summary: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths worldwide. It is often diagnosed at advanced stages with poor prognosis due to lack of early symptoms. Exosomal circRNAs have been shown to play promoter or suppressor roles in the carcinogenesis, progression, and metastasis of HCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Ting Song, Li Li, Shaobo Wu, Yan Liu, Caiping Guo, Wen Wang, Lili Dai, Tong Zhang, Hao Wu, Bin Su
Summary: Hepatocellular carcinoma (HCC) is a common and highly lethal cancer, and genetic biomarkers are increasingly playing a crucial role in early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Article
Medical Laboratory Technology
Ting Wang, Hengkai Zhu, Min Xiao, Shao Zhou
Summary: The study found that serum exosomal lncRNA CRNDE is significantly increased in HCC patients, and is associated with tumor size, differentiation, and prognosis. High expression is linked to poorer prognosis, while patients with low expression have longer survival. Therefore, serum lncRNA CRNDE may serve as a potential biomarker for diagnosis and prognosis of HCC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Kai Zhu, Qiqi Tao, Jiatao Yan, Zhichao Lang, Xinmiao Li, Yifei Li, Congcong Fan, Zhengping Yu
Summary: The study found that exosome-related gene signatures can accurately predict the prognosis of hepatocellular carcinoma patients and have potential clinical value.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Risheng He, Zhongrui Wang, Wenguang Shi, Liang Yu, Haoming Xia, Ziyue Huang, Shuqiang Liu, Xudong Zhao, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
Summary: This review explores the role of exosomes in HCC and emphasizes the impact of exosome-mediated cellular material transfer on HCC progression. The potential molecular mechanisms underlying these effects are discussed, with the hope of shedding new light on the diagnosis and treatment strategies for HCC.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Somayeh Yazdanparast, Zoufang Huang, Shayan Keramat, Mehrdad Izadirad, Yi-Dong Li, Letao Bo, Ahmad Gharehbaghian, Zhe-Sheng Chen
Summary: Exosomal miRNAs have shown potential as diagnostic, prognostic, therapeutic, and predictive biomarkers in DLBCL, but more research is needed.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Tanghua Li, Jiapeng Jiao, Haoteng Ke, Wenshan Ouyang, Luobin Wang, Jin Pan, Xin Li
Summary: Despite improved treatment methods, hepatocellular carcinoma (HCC) still has a high mortality rate. Recent studies have shown the potential of immunotherapy in cancer treatment. Exosomes play a role in regulating the immune system in HCC, and understanding their role can improve the effectiveness of immunotherapy. Engineered exosomes can deliver drugs and RNA molecules to regulate the immune microenvironment of HCC, improving the mortality rate. This study aims to declare the role of exosomes in HCC and provide potential treatment options for clinical transformation therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Hang Wang, Liang Yu, Peng Huang, Yongxu Zhou, Wangyang Zheng, Nanfeng Meng, Risheng He, Yi Xu, Tey Sze Keong, Yunfu Cui
Summary: Hepatocellular carcinoma is a challenging global disease with limitations in diagnosis and treatment. Extracellular vesicles have unprecedented potential in cancer research as antitumor vaccines and drug carriers. In the past decade, the study of extracellular vesicles in hepatocellular carcinoma has made significant progress.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Bufu Tang, Jinyu Zhu, Zhongwei Zhao, Chenying Lu, Siyu Liu, Shiji Fang, Liyun Zheng, Nannan Zhang, Minjiang Chen, Min Xu, Risheng Yu, Jiansong Ji
Summary: In this study, TMB-specific genes with good prognostic value were identified to establish diagnostic and prognostic models for HCC patients. Patients with high prognostic risk showed poorer survival probability and higher infiltration of immune cells, drug resistance, and cell proliferation and migration. These findings provide guidance for treatment strategies and improving outcomes in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Immunology
Hanren Chen, Shulian Jiang, Peng Zhang, Zhongyu Ren, Jian Wen
Summary: Exosomes as vehicles synergized with PIONs@E6 can enhance immunity against HCC by promoting M1 macrophages polarization. The PIONs-contained exosomes showed dose-dependent promotion of M1 macrophages polarization, higher ROS levels in macrophages, and significant inhibition of tumor growth in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Jia-Mei Dong, Rui-Qi Wang, Ning-Ning Yuan, Jia-Hao Guo, Xin-Yang Yu, Ang-Hui Peng, Jia-Yi Cai, Lei Xue, Zhi-Ling Zhou, Yi-Hao Sun, Ying-Yin Chen
Summary: Hepatocellular carcinoma (HCC), accounting for 90% of all primary liver cancers, is a major malignancy globally. Aptasensors, known for their high sensitivity, excellent selectivity, and low production costs, have attracted attention for the diagnosis and surveillance of HCC. Optical aptasensors, offering advantages of a wide range of targets, rapid response, and simple instrumentation, show great potential in early diagnosis and prognosis monitoring of HCC. This review summarizes recent progress in various types of optical aptasensors for biomarkers in HCC, evaluates their strengths and limitations, and discusses the challenges and future perspectives for their use in HCC diagnosis and surveillance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biophysics
Mehdi Mohammadi, Hossein Zargartalebi, Razieh Salahandish, Raied Aburashed, Kar Wey Yong, Amir Sanati-Nezhad
Summary: This study provides an overview of the role of exosomes in cancer diagnosis and prognosis, investigates emerging exosome technologies, evaluates the advantages and drawbacks of different technologies, and discusses their clinical challenges for cancer diagnosis and prognosis. Commercial platforms for exosomal detection and analysis are introduced, with a focus on their performance and impact on cancer diagnosis and prognosis, as well as the risks associated with the development of next-generation exosome devices.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Xiaofeng Xue, Xiaona Wang, Yubin Zhao, Rongkuan Hu, Lei Qin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Xiaofeng Xue, Xiaoyan Fei, Wenjie Hou, Yajie Zhang, Liu Liu, Rongkuan Hu
Article
Biochemistry & Molecular Biology
Yang Shi, Xiaohua Yang, Xiaofeng Xue, Ding Sun, Peng Cai, Qingwei Song, Bin Zhang, Lei Qin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Haitao Huang, Yuxuan Wang, Qin Li, Xiaoyan Fei, Haitao Ma, Rongkuan Hu
Article
Pharmacology & Pharmacy
Yan Liu, Tingting Bi, Linxun Liu, Quangen Gao, Genhai Shen, Lei Qin
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Xu-Dong Wang, Rongkuan Hu, Qing Ding, Trisha K. Savage, Kenneth E. Huffman, Noelle Williams, Melanie H. Cobb, John D. Minna, Jane E. Johnson, Yonghao Yu
NATURE COMMUNICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Qin Li, Yuxuan Wang, Rongkuan Hu, Guang Yang
ONCOTARGETS AND THERAPY
(2020)
Article
Biotechnology & Applied Microbiology
Yachen Zang, Jin Zhu, Qin Li, Jian Tu, Xiaoqing Li, Rongkuan Hu, Dongrong Yang
ONCOTARGETS AND THERAPY
(2020)
Article
Chemistry, Medicinal
Qin Li, Jie Ren, Wei Liu, Guoqin Jiang, Rongkuan Hu
Summary: This research identified a novel CpG-B class ODN to promote the immune response, while demonstrating that combination of CpG with mRNA cancer vaccines enhanced the antitumor effect in melanoma models. The study also showed the long-term safety and tolerability of CpG2018B and mRNA therapy in mice, suggesting a promising approach for immunostimulatory sequence (ISS)-based therapeutic strategies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Yufan Wu, Taihe Fan, Yubin Zhao, Rongkuan Hu, Dongdong Yan, Ding Sun, Ling Gaol, Lei Qin, Xiaofeng Xue
Summary: The downregulation of hsa_circ_0001306 in HCC promotes tumor cell proliferation and invasion, and plays an important role through the miR-527/FBXW7 axis.
Article
Biochemistry & Molecular Biology
Fuliang Qian, Qingqing Hu, Yali Tian, Jie Wu, Dapeng Li, Min Tao, Lei Qin, Bairong Shen, Yufeng Xie
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Oncology
Yan Liu, Lei Qin, Tingting Bi, Wei Dai, Wei Liu, Quangen Gao, Genhai Shen