Article
Oncology
Xiao Xiao, Ge Jiang, Shengtao Zhang, Shuo Hu, Yunshan Fan, Gang Li, Haiyang Yu, Shisheng He
Summary: This study identified the expression and function of lncRNA SNHG16 in osteosarcoma, showing that it acts as an oncogene by regulating miR-1285-3p, potentially serving as a novel target for osteosarcoma therapy.
Article
Oncology
Haiyan Fan, Liangjia Ding, Yun Yang
Summary: OA is a common age-related joint disorder and lncRNA SNHG16 was found to be upregulated in OA tissue, potentially limiting the progression of OA by regulating miR-373-3p, indicating SNHG16 may serve as a potential therapeutic target for OA.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Yuanyuan Fu, Dionyssios Katsaros, Nicoletta Biglia, Zhanwei Wang, Ian Pagano, Marcus Tius, Maarit Tiirikainen, Charles Rosser, Haining Yang, Herbert Yu
Summary: This study identified the important role of lncRNA TOPORS-AS1 in ovarian cancer, where high expression was associated with favorable survival outcomes. Experimental evidence suggests that TOPORS-AS1 may act as a tumor suppressor in ovarian cancer by disrupting the Wnt/beta-catenin signaling pathway. Furthermore, the upregulation of TOPORS-AS1 by VDR supports its potential as a prognostic marker and therapeutic target in ovarian cancer.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Lin Huang, Ying Ding, Lu Yang, Xinghua Jiang, Zhen Xia, Zhigang You
Summary: The study demonstrated that highly expressed SNHG16 promotes proliferation and migration of HCASMC by targeting miR-218-5p through the Wnt/beta-catenin signaling pathway, leading to the development and recurrence of coronary heart disease (CHD).
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Editorial Material
Oncology
Barbara Pardini, Mihnea P. Dragomir
Summary: The study by Zagorac et al. unveils a novel molecular mechanism in breast cancer involving SOX2, EZH2, and the long noncoding RNA SCIRT. Upregulation of SCIRT may lead to the dedifferentiation of TICs into a less tumorigenic phenotype and offer new therapeutic opportunities.
Article
Multidisciplinary Sciences
Weidun Xie, Xingjian Chen, Zetian Zheng, Fuzhou Wang, Xiaowei Zhu, Qiuzhen Lin, Yanni Sun, Ka-Chun Wong
Summary: This study presents a method called lncRNA-Top to predict lncRNA-gene regulation relationships and constructs controlled deep-learning models. Through case studies, it is found that the predictions are accurate, and additional software is provided for target candidate annotation.
Article
Chemistry, Multidisciplinary
Marwa M. Esawy, Amir Abd-elhameed, Ahmed F. Gomaa, Shereen A. Baioumy, Moataz A. ElKot, Mohammed A. Hegab, Ahmed S. Alazzouni, Felwa A. Thagfan, Rewaida Abdel-Gaber, Mohamed A. Dkhil, Marwa A. Shabana
Summary: This study investigated the roles of LncRNA-GAS5 and S-catenin in predicting asymptomatic organ damage (AOD) in hypertensive nondiabetic patients. It found that decreased LncRNA-GAS5 expression and elevated S-catenin levels were associated with AOD in hypertensive patients. LncRNA-GAS5 expression was a better diagnostic predictor of AOD than S-catenin.
Article
Cell Biology
Yonghui Liu, Chengwen Zhao, Guihua Wang, Jing Chen, Shaoqing Ju, Jianfei Huang, Xudong Wang
Summary: In colorectal cancer (CRC), SNORD1C promotes cancer cell stemness through the Wnt/beta-catenin pathway. High expression of SNORD1C is associated with poor prognosis in CRC, and targeting SNORD1C may be a potential novel therapeutic strategy for CRC.
CELL DEATH DISCOVERY
(2022)
Article
Medical Laboratory Technology
Chen Xie, Bin Zhu, Juxian Gu, Muhua Sun
Summary: This study evaluated the prognostic value of long non-coding RNA SNHG16 in patients with acute ischemic stroke (AIS). The results showed that SNHG16 was associated with lower inflammatory cytokines, adhesion molecules, and milder disease severity, but it failed to predict prognosis in AIS patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Yuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Jonathan Wang, Tiffany Adam, Wei Wei, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo
Summary: This study reveals that XIST plays a crucial role in regulating breast cancer stem cells by activating IL-6 proinflammatory signaling pathway. This finding is significant for understanding the mechanism of breast cancer development.
Article
Cell Biology
Min Wang, Chi Yin, Zhengquan Wu, Xinwen Wang, Qijun Lin, Xingyu Jiang, Hong Du, Chuandong Lang, Xinsheng Peng, Yuhu Dai
Summary: The long transcript of TMPO-AS1 (TMPO-AS1(L)) is upregulated in prostate cancer tissues with bone metastasis and promotes bone metastatic capacity via activation of the Wnt/β-catenin signaling pathway. TMPO-AS1(L) may serve as a candidate marker for the prognosis and therapeutic targeting of prostate cancer bone metastasis.
CELL DEATH DISCOVERY
(2023)
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Mei Hua Chen, Li Sheng Fu, Fan Zhang, Ying Yang, Xing Zhong Wu
Summary: The study revealed that m6A-modified lncAY functions through m6A reader protein YTHDF2 to upregulate BMI1 expression in HCC cells, showing a positive correlation between the two. BMI1 was found to be upregulated in HCC tissues and higher BMI1 expression in patients was associated with poor clinical prognosis, indicating a novel regulatory signaling pathway involved in liver cancer progression.
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Xianqiu Wu, Yang Liu, Song Mo, Wuli Wei, Ziliang Ye, Qiang Su
Summary: The study revealed the significance of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 axes in MIRI, promoting myocardial ischemia-reperfusion injury by affecting cell survival and apoptosis.