Review
Pharmacology & Pharmacy
Mehdi Alidadi, Ahmed Hjazi, Irfan Ahmad, Reza Mahmoudi, Masoud Sarrafha, Seyed Reza Hosseini-Fard, Mohammadreza Ebrahimzade
Summary: Atherosclerosis is a disease caused by LDL and inflammation, which affects the sub-endothelial space. Various factors, including inflammation, LDL oxidation, endothelial dysfunction, foam cell formation, and smooth muscle cell proliferation and migration, are involved in the pathogenesis of atherosclerosis. Crosstalk among atherosclerosis-induced cells plays an important role in modulating the disease. Exosomes, a type of extracellular vesicle, have been found to carry bioactive components like proteins, lipids, RNA, and DNA, and can affect the communication between sub-endothelial cells. Noncoding RNAs, such as microRNAs, long noncoding RNAs, and circular RNAs, which are important cargo in exosomes, can regulate cellular functions. This study aims to investigate the molecular mechanisms of exosomal ncRNAs and their potential as diagnostic biomarkers and therapeutic targets in atherosclerosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Samina Shabbir, Prerona Boruah, Lingli Xie, Muhammad Fakhar-e-Alam Kulyar, Mohsin Nawaz, Salsabeel Yousuf, Tianyi Liu, Farhat Jabeen, Xiangyang Miao
Summary: Genome-wide sequencing of lncRNAs and mRNAs in ovaries of Hu sheep at different ages revealed key genes and regulatory pathways associated with ovarian development, follicular development, and steroid hormone biosynthesis. Identified genes were found to play vital roles in the final stages of follicles and ovary development in Hu sheep.
SCIENTIFIC REPORTS
(2021)
Letter
Oncology
Xi Yang, Lijun Liu, Xuemin Shen, Linjun Shi, Wei Liu
Summary: Increasing evidence suggests that lncRNAs act as ceRNAs by competitively binding miRNAs, and play important roles in the biological processes of TSCC. This study summarizes the ceRNA regulatory networks involving lncRNA/miRNA/mRNA axes in TSCC. Dysregulated profiles of 33 lncRNAs and 31 miRNAs were identified and found to be involved in various cancer-associated phenotypes, including cell proliferation, apoptosis, invasion, migration, and chemoresistance. The functional inactivation of ceRNAs in tumor cells may provide novel diagnostic and therapeutic strategies for TSCC.
Review
Peripheral Vascular Disease
Ji-Ru Zhang, Hai-Jian Sun
Summary: Hypertension, a multifactorial disorder, involves the dysregulation of vascular smooth muscle cells (VSMCs) which play a crucial role in the development of systemic hypertension and pulmonary arterial hypertension (PAH). Noncoding RNAs (ncRNAs) are emerging as novel modulators in the biological behaviors of VSMCs, with microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs being recommended as predictive biomarkers and therapeutic targets for hypertension and PAH.
HYPERTENSION RESEARCH
(2021)
Review
Cell Biology
Elahe Soltani-Fard, Marzieh Asadi, Sina Taghvimi, Asma Vafadar, Parisa Vosough, Amir Tajbakhsh, Amir Savardashtaki
Summary: Endometriosis is a gynecological disorder characterized by the growth of endometrial-like cells outside the uterus. It is difficult to diagnose noninvasively, leading to delays in treatment and increased burden on patients. Exosomes, which transport bioactive molecules, including microRNAs and long noncoding RNAs, have been found to play a significant role in endometriosis development. This review focuses on the potential functions of exosomal noncoding RNAs in the therapy and diagnosis of endometriosis.
CELL AND TISSUE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fang Xu, Liya Jiang, Qianwei Zhao, Zhibiao Zhang, Yixian Liu, Shuangshuang Yang, Mengdan Yu, Huiping Chen, Jianying Zhang, Jintao Zhang
Summary: This study analyzed HCC tumor and adjacent normal tissue samples using TMT-labeled tandem mass spectrometry and whole-transcriptome sequencing, identifying 977 differentially expressed proteins and 243 genes, and comprehensively evaluating gene-regulatory circuits in HCC. Bioinformatics analysis revealed involvement of certain miRNAs in regulating hub genes, while crucial coexpression and competing endogenous RNA interaction axes revealed potential functions of lncRNAs and circRNAs in HCC.
Review
Biochemistry & Molecular Biology
Wuwen Zhang, Qinshi Wang, Yi Yang, Siyuan Zhou, Ping Zhang, Tongbao Feng
Summary: Exosomes play a crucial role in cell-cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are key regulators in cancer development, involved in processes such as cancer cell proliferation, metastasis, drug resistance, and immunomodulation. Changes in exosomal lncRNAs levels often correlate with cancer occurrence and progression, making them valuable biomarkers for cancer diagnosis and prognosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Jiangning Zhao, Huanrong Lin, Kunsong Huang, Shen Li
Summary: In this study, it was found that cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) carrying SNHG3 can promote colorectal cancer (CRC) cell proliferation through the miR-34b-5p/HuR/HOXC6 axis. These findings reveal the important role of CAFs-EVs in CRC progression.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Maria Teresa Di Martino, Caterina Riillo, Francesca Scionti, Katia Grillone, Nicoletta Polera, Daniele Caracciolo, Mariamena Arbitrio, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: Cancer onset and progression are influenced by immune system dysregulation, with noncoding RNAs playing a role in cancer cell immune escape and modulation of the tumor microenvironment. While immunotherapy holds promise for cancer treatment, efforts are needed to achieve cure for immune-refractory tumors.
Review
Immunology
Juan-Juan Han, Xue-Qiang Wang, Xin-An Zhang
Summary: This review comprehensively summarizes the regulatory mechanisms of lncRNA/circRNA-miRNA-mRNA network in rheumatoid arthritis (RA) and discusses the potential roles of non-coding RNAs as biomarkers and therapeutic targets for the diagnosis and treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dezhong Lv, Zhenghong Chang, Yangyang Cai, Junyi Li, Liping Wang, Qiushuang Jiang, Kang Xu, Na Ding, Xia Li, Juan Xu, Yongsheng Li
Summary: TransLnc is a database that provides experimentally supported and predicted lncRNA peptides in multiple species, with hundreds of thousands of peptides recorded. Various types of evidence supporting the coding potential of lncRNAs are integrated, and users can access lncRNA peptides in 34 tissues and predicted tumor neoantigens.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Wenyan Du, Chengbin Lei, Yanzhen Wang, Yiwen Ding, Peng Tian
Summary: The study demonstrated that LINC01232 is upregulated in patients with pancreatic adenocarcinoma (PAAD), and high levels of LINC01232 in serum could predict unfavorable prognosis. miR-204-5p, miR-370-5p, and miR-654-3p are proposed as potential targets of LINC01232 in PAAD, showing clinical significance in diagnosis and prognosis.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Mathematical & Computational Biology
Jianlong Shu, Minhua Chen, Chunse Ya, Ruixia Yang, Fengzhen Li
Summary: This study explores the regulatory functions of ceRNA networks in the pathogenesis of gout. The ceRNA networks constructed with differentially expressed lncRNAs, miRNAs, and mRNAs were found to be involved in gene transcription, RNA polymerase II transcription, and the regulation of cell growth and apoptosis. The TTTY10/hsa-miR-139-5p/AP-1 axis is likely to be of clinical significance in gout.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Editorial Material
Genetics & Heredity
Claire Wilson, Aditi Kanhere
Summary: This study speculates on the potential role of variants of lncRNAs in cancer development by drawing upon emerging research findings.
TRENDS IN GENETICS
(2021)
Article
Plant Sciences
Alok Kumar Panda, Hukam C. Rawal, Priyanka Jain, Vishnu Mishra, Jyoti Nishad, Soni Chowrasia, Ananda K. Sarkar, Priyabrata Sen, Soumendra Kumar Naik, Tapan Kumar Mondal
Summary: This study explored the regulation of miRNAs and lncRNAs in response to deepwater stress in rice. Through small RNA-seq and RNA-seq analysis, deepwater stress responsive miRNAs and lncRNAs were predicted. Additionally, a ceRNA study revealed the interactions between certain miRNAs and lncRNAs. Furthermore, transient expression analysis in tobacco leaves provided insights into the regulatory network of miRNAs, lncRNAs, and their target genes in stem elongation under deepwater stress.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Energy & Fuels
Athar Sadat Javanmard, Maryam M. Matin, Ahmad Reza Bahrami
Summary: Cellulases are essential industrial enzymes used in various industries such as biofuel production, paper and pulp, textiles, and detergents. This study successfully expressed a thermophilic cellulase collection in the methylotrophic yeast Pichia pastoris. The results showed that CglT is a potential candidate for completing cellulase collections with low beta-glucosidase activity, which is important for biofuel production due to its high glucose tolerance property.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Toxicology
Hamid Cheshomi, Ahmad Reza Bahrami, Houshang Rafatpanah, Maryam M. Matin
Summary: This study demonstrated that ellagic acid, a component of pomegranate and its derivatives, has significant anti-cancer effects on gastric adenocarcinoma by inhibiting cell proliferation and migration, reducing inflammation, and promoting cancer cell death. In a mouse model, ellagic acid also showed promising results in reducing tumor volume without notable side effects, suggesting its potential as a safe anti-cancer agent for further preclinical studies.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Physical
Hossein S. Moradi, Elham Momenzadeh, Monireh Asar, Sonia Iranpour, Ahmad Reza Bahrami, Maryam Bazargan, Halimeh Hassanzadeh, Maryam M. Matin, Masoud Mirzaei
Summary: The bioactivity of two heteroleptic copper complexes based on pyridinedicarboxylic acid N-oxide and 2,2'bipyridine with potential anti-cancer activities was reported. Complex 1 exhibited the strongest synergistic effect when combined with topotecan, with apoptosis being the main mechanism of cell death. Overall, the complexes significantly inhibited the proliferation of cancerous cells and complex 1 showed promise as a potential chemotherapeutic agent for cervical cancer treatment when used in combination with other drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Morteza Tahmasebi, Masoud Mirzaei, Maryam M. Matin, Sonia Iranpour, Joel T. Mague
Summary: A new inorganic-organic hybrid based on proline functionalized gamma-octamolybdate was synthesized and characterized. The hybrid exhibited significant anti-cancer activity against human-derived colon cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Medicine, Research & Experimental
Samira Shahraki, Alireza Ebrahimzadeh Bideskan, Mohammad Aslzare, Mahmoud Tavakkoli, Ahmad Reza M. Bahrami, Sara Hosseinian, Maryam M. Matin, Abolfazl Khajavi Rad
Summary: This study successfully developed human ECM renal scaffolds using Triton X-100 decellularization method, supporting adhesion and proliferation of hAd-MSCs and inducing their differentiation towards a renal lineage.
Article
Cell Biology
Elahe Khakpour, Amin Tavassoli, Nasser Mahdavi-Shahri, Maryam M. Matin
Summary: This study successfully decellularized bovine Achilles tendon using a combination of physical and chemical treatments, and investigated the cytocompatibility of the decellularized tendon scaffold with hAd-MSCs and blastema cells. The results showed that this decellularization protocol effectively supported the maintenance and growth of both hAd-MSCs and blastema cells, indicating its potential for tendon tissue engineering.
CELL AND TISSUE BANKING
(2023)
Article
Chemistry, Physical
Zeinab Sadat Hosseini, Amin Abdollahi, Ali Dashti, Maryam M. Matin, Amin Afkhami-Poostchi
Summary: Stimuli-responsive core-shell nanoparticles are an important class of smart polymers that exhibit changes in physical and chemical properties in response to external stimuli. In this study, two series of core-shell nanoparticles were synthesized and their responsive behaviors towards temperature, pH, and CO2 gas were investigated. The results showed that the nanoparticles with a PS-PDMAEMA structure exhibited the highest antimicrobial activity.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Medicine, Research & Experimental
Mehrdad Aghasizadeh, Tayebe Moghaddam, Ahmad Reza Bahrami, Hamid Sadeghian, Seyed Jamal Alavi, Maryam M. Matin
Summary: Carbostyril derivatives have been found to inhibit the growth of prostate cancer cells. These compounds effectively inhibit 15-LOX activity and induce cytotoxicity in prostate cancer cells through apoptosis. In vivo studies show that 8-GQ has stronger anti-tumor effects and fewer side effects on normal tissues compared to cisplatin.
Article
Anatomy & Morphology
Sara Mirzaei, Milad Iranshahy, Hamid Gholamhosseinian, Maryam M. Matin, Fatemeh B. Rassouli
Summary: Urolithins have the potential to improve the efficacy of chemotherapy, radiation therapy, and hyperthermia in the treatment of esophageal cancer. They increase the toxicity of chemotherapeutic drugs and radiation, enhance the effects of hyperthermia, and promote apoptosis in cancer cells.
Article
Biotechnology & Applied Microbiology
Aseel Kamil Mohammad Al-Mosawi, Ahmad Reza Bahrami, Sirous Nekooei, Amir Sh. Saljooghi, Maryam M. Matin
Summary: In this study, magnetic mesoporous silica nanoparticles (MSNs) loaded with 5-fluorouracil (5-FU) and surface-decorated with polyethylene glycol (PEG) and epithelial cell adhesion molecule (EpCAM) aptamer (Apt) were developed for controlled release of 5-FU and targeted treatment of colorectal cancer (CRC). Au NPs were conjugated to the exterior surface of MSNs as a gatekeeper for intelligent drug release. The results demonstrated the potential of this theranostic platform in targeted drug delivery and treatment of CRC.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Fatemeh Maleki, Hamid Sadeghian, Ahmad Reza Bahrami, Seyed Navid Goftari, Maryam Moghaddam Matin
Summary: This study assessed the anti-cancer properties of some coumarin derivatives as possible 15-LOX-1 inhibitors on PC-3 prostate cancer cells. The results indicated that 8-GC and 8-GCC can be introduced as effective anticancer agents with apoptosis-inducing properties.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Azadeh Haghighitalab, Massimo Dominici, Maryam M. Matin, Faezeh Shekari, Majid Ebrahimi Warkiani, Rebecca Lim, Naghmeh Ahmadiankia, Mahdi Mirahmadi, Ahmad Reza Bahrami, Hamid Reza Bidkhori
Summary: Conventional immune suppressive therapies for autoimmune diseases have limitations and complications. Tolerogenic therapeutic strategies based on stem cells, immune cells, and their extracellular vesicles (EVs) are promising for managing these diseases. Mesenchymal stem/stromal cells (MSCs), dendritic cells, and regulatory T cells (Tregs) are the main cell types used, with MSCs playing a more beneficial role. EV-based therapies are gaining attention as cell-free therapeutic paradigms and have unique properties as smart immunomodulators. This review discusses the advantages and disadvantages of cell-based and EV-based methods and the future outlook of EVs in autoimmune disease treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Zahra Ghanbari Movahed, Maryam M. M. Matin, Kamran Mansouri, Sajjad Sisakhtnezhad
Summary: This study investigated the changes in the amino acid profile in MCF-7 and MDA-MB-231 cells during spheroid formation and identified specific metabolic properties in breast cancer stem cells.
Article
Cell & Tissue Engineering
Mahboubeh Kazemi Noughabi, Maryam M. Matin, Moein Farshchian, Ahmad Reza Bahrami
Summary: Nanos2 expression in mouse mesenchymal stromal/stem cells downregulates immune-related genes and exhibits anti-inflammatory effects. This approach may be useful in controlling clinical inflammatory conditions, although further research is needed.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Aliakbar Haddad-Mashadrizeh, Maryam M. Matin, Fahimeh Shahabipour, Shabnam Ensandost, Alireza Zomorodipour, Ahmad Reza Bahrami
Summary: This study explored the efficacy of cell-seeded beta-GP-HEC scaffold in liver transplantation, demonstrating improved cell survival and reduced cell migration out of the target area. It successfully monitored the migration and distribution of cells in vivo over a 6-month period, with scaffold-free samples showing signs of reduced cellular augmentation over time. The application of the scaffold proved to be effective in preventing unnecessary cell migration to other organs.
EMERGENT MATERIALS
(2022)