Article
Biochemistry & Molecular Biology
Anthony J. Hayes, John Whitelock, James Melrose
Summary: The aim of this study was to investigate the roles of perlecan in the regulation of cartilage development and homeostasis. The study showed that perlecan interacts with various molecules to promote matrix stabilization, cellular proliferation, and tissue expansion. Furthermore, perlecan is involved in chromatin structure modulation and gene regulation. Snail-1 and FGF family members play important roles in chondrogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Danny Bergeron, Cedric Laforest, Stacey Carpentier, Annabelle Calve, Etienne Fafard-Couture, Gabrielle Deschamps-Francoeur, Michelle S. Scott
Summary: The study reveals that snoRNA copy regulation affects family sizes, genomic location of the members, and controls both member and total family abundance to meet the needs of individual tissues. Additionally, the expression variability of individual snoRNA family members is preferred over the total variability of the family, pointing towards differential regulation mechanisms exist to ensure uniformity of the total family abundance across tissues.
Article
Biochemistry & Molecular Biology
Alon Botzer, Yoram Finkelstein, Ron Unger
Summary: Blood pressure is determined by various physiological factors regulated by complex neural, endocrine, and paracrine mechanisms. Genes related to BP regulation are predominantly expressed in the kidney and adrenals of complex organisms, and in the nervous system of low complexity organisms. The complex system of BP regulation has evolved from simpler components to maintain key homeostatic functions in organisms' existence and survival.
Article
Environmental Sciences
Giancarlo Garofalo, Tyson Nielsen, Samuel Caito
Summary: This study found that the environmental toxicant methylmercury affects the expression of miRNA, leading to dysregulation of lipid metabolism. The changes in the affected miRNA sequences by MeHg may be a potential mechanism underlying lipid accumulation.
Article
Chemistry, Physical
Chuanxian Zhang, Beilei Zhang, Chu Tang, Xiaorui Shi, Bin Guo, Fu Wang
Summary: microRNAs (miRNAs), a class of non-coding small RNAs, play a crucial role in various biological processes and diseases. This study presents a gene-switch system, Gal-miR, which allows visualization and regulation of miRNA activity. By controlling the expression of a downstream luciferase gene using endogenous miRNA machinery, the Gal-miR system converts miRNA-mediated gene silencing into a bioluminescent signal, providing quantitative measurement of miRNA-206 activity during myogenic differentiation. Furthermore, this system effectively inhibits breast cancer cell viability, migration, and invasion by replacing the downstream gene with melittin functional gene, under the control of specific miRNAs. This study offers a powerful genetic design for precise control of transgene expression and visualization of miRNA activity.
Article
Plant Sciences
Madiha Zaynab, Jiaofeng Peng, Yasir Sharif, Mohammed Albaqami, Rashid Al-Yahyai, Mahpara Fatima, Muhammad Azhar Nadeem, Khalid Ali Khan, Saqer S. Alotaibi, Ibrahim A. Alaraidh, Hassan O. Shaikhaldein, Shuangfei Li
Summary: This study conducted a comprehensive analysis of DDP proteins in the potato genome, identifying 10 DDP genes and studying their characteristics in terms of phylogenetics, gene duplication, expression profiles, and promoter regions involved in stress response. The research revealed that StDDP genes were distributed across different clades, and exhibited various expression patterns in response to heat stress and salt stress. Real-time qPCR results indicated that StDDPs played significant roles in potato growth and development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemical Research Methods
Ying Li, Qianhuan Guo, Meng Wang, Chengchao Zheng, Kang Yan
Summary: MicroRNAs have been identified as important regulators of post-transcriptional degradation and translational repression in both plants and animals. In this study, the relationship between intronic miRNAs and their host genes in Arabidopsis was investigated using transgenic plants. The results showed that there is an independent relationship between the processing of intronic miRNAs and their host genes in Arabidopsis.
PLANT MOLECULAR BIOLOGY REPORTER
(2022)
Review
Biochemistry & Molecular Biology
Bartosz Lenda, Marta Zebrowska-Nawrocka, Grzegorz Turek, Ewa Balcerczak
Summary: Gliomas, particularly glioblastoma, are aggressive brain tumors with limited treatment options and poor prognosis. Although gliomas do not undergo classical epithelial to mesenchymal transition (EMT), EMT-like processes contribute to their invasive nature and intracranial metastasis. Various EMT transcription factors have been described to play important roles in glioma progression, with a focus on molecules like SNAI, TWIST, and ZEB. This review highlights the impact of miRNA, lncRNA, and other epigenetic modifications on the regulation of EMT transcription factors in gliomas, emphasizing the need to uncover the molecular mechanisms and identify novel therapeutic targets for improved diagnosis and prognosis of glioma patients.
Article
Biotechnology & Applied Microbiology
Mahnaz Nezamivand-Chegini, Esmaeil Ebrahimie, Ahmad Tahmasebi, Ali Moghadam, Saeid Eshghi, Manijeh Mohammadi-Dehchesmeh, Stanislav Kopriva, Ali Niazi
Summary: The study analyzed the evolution of the SPX gene family in legumes and other species, revealing fluctuations in different classes of SPX proteins in different plants, as well as the sub- or neo-functionalization of duplicated genes in legumes. Functional orthologs in soybean and Medicago were identified using two different methods.
Article
Immunology
Si Wang, Jing Xu, Yuanxu Guo, Yongsong Cai, Xiaoyu Ren, Wenhua Zhu, Manman Geng, Liesu Meng, Congshan Jiang, Shemin Lu
Summary: Mounting evidence suggests that miRNAs, especially the miR-15/107 family, play a role in rheumatoid arthritis (RA). In this study, miR-424 and miR-497 were found to be dysregulated in RA patients, with significant effects on cell proliferation and apoptosis of RASF. A proposed miR-424-DICER1-miR-497 feedback loop offers a novel insight into regulating miRNA expression and controlling RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbora Hanouskova, Gabriela Vavrova, Martin Ambroz, Iva Bousova, Tommy A. Karlsen, Lenka Skalova, Petra Matouskova
Summary: The study found that miR-137 and miR-29b can inhibit GPx7 expression through certain mechanisms, but no negative correlation between miRNAs and GPx7 was observed during adipogenesis. This suggests that the action of miR-137 and miR-29b in adipogenesis and mature adipocytes must be accompanied by other regulators.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Cell Biology
Shubo Li, Shufang Li
Summary: CCN proteins play important regulatory roles in the development and function of adult organs. This study aimed to investigate the expression of CCN1, CCN3, CCN4, CCN5, and CCN6 during postnatal tooth development and the formation of periodontium.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Fangfang Yang, Guoyun Xuan, Yixin Chen, Lichao Cao, Min Zhao, Chen Wang, Erfei Chen
Summary: Colorectal cancer is a common type of cancer and a leading cause of mortality worldwide. MicroRNAs play important roles in the development and progression of colorectal cancer, serving as clinical biomarkers and therapeutic targets. However, the complex network of miRNA/target regulation in colorectal cancer remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Mengying Zhang, Xiyun Jin, Junyi Li, Yi Tian, Qi Wang, Xinhui Li, Juan Xu, Yongsheng Li, Xia Li
Summary: CeRNASeek is an R package that integrates multiple-omics data to identify and analyze ceRNA-ceRNA interactions. It provides six computational methods and various downstream analyses, suitable for studying the function of ceRNAs in complex diseases.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell Biology
Chao Sun, Han Zhang, Xinhui Liu
Summary: Fibrosis is a serious threat to human health and life, closely associated with disability and death from chronic diseases. The CCN protein family plays a key role in the pathological process of fibrosis, highlighting its potential for developing new drugs and determining clinical strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jaeyeon Lim, Chihiro Tanikawa, Mikihiko Kogo, Takashi Yamashiro
Summary: This study used artificial intelligence systems to determine prognostic factors for orthognathic surgery in children with cleft lip and/or palate. Factors identified included the number of clefts, palatal repair method, male sex, cephalometric variables, growth patterns, and number of missing teeth.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Chi Ngai Lo, Tarek Abdelkader, Yik Ming Choi, Anthony James Goff, Krishnasamy Suresh, Guiller Augustin Cea Carpio, Benjamin Soon
Summary: This study compares the effectiveness of 3D images produced by photogrammetry and traditional 2D images in introducing manual therapy skills to physiotherapy students. The results show that for learning three cervical spine assessment skills, 3D images produced by photogrammetry are more effective than 2D images for first-year physiotherapy students.
SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN HEALTHCARE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Koji Fujiyama, Yohei Kera, Shimizu Yujin, Chihiro Tanikawa, Takashi Yamashiro, Xiaohan Guo, Andy Ni, Toru Deguchi
Summary: The study shows that both Invisalign and conventional fixed appliances are effective in treating patients with a severe deep overbite. Invisalign therapy may be more preferable for patients with high angle and deep overbite compared to conventional fixed appliance therapy.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yuujin Shimizu, Chihiro Tanikawa, Tomoyuki Kajiwara, Hajime Nagahara, Takashi Yamashiro
Summary: This study aimed to evaluate the performance of two artificial intelligence systems in creating prioritized problem lists and treatment plans, and compare them with orthodontists. The results showed that the AI systems performed similarly to orthodontists in some aspects, but not as well in others.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jun Maeda, Chihiro Tanikawa, Namiki Nagata, Jaeyeon Lim, Sven Kreiborg, Shumei Murakami, Takashi Yamashiro
Summary: The study evaluated the errors of three-dimensional mandibular surfaces generated using MRI data compared to the gold standard of CT. Random errors were quantified for the 3-D rendering of the mandible, with most regions showing minimal detectable change values that allowed for evaluation. The coronoid region had the greatest errors, but overall there was 'almost perfect' agreement between the CT and MRI imaging.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Takashi Yamashiro, Hiroshi Kurosaka, Toshihiro Inubush
Summary: The Runx family genes are crucial transcriptional regulators in tissue development. Recent studies have revealed their novel roles in tooth, salivary gland, and palate development. Future studies may uncover additional roles of Runx signaling pathways in morphogenesis.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
N. Shalehin, Y. Seki, H. Takebe, S. Fujii, T. Mizoguchi, H. Nakamura, N. Yoshiba, K. Yoshiba, M. Iijima, T. Shimo, K. Irie, A. Hosoya
Summary: Gli1(+) cells in the periodontal ligament are mesenchymal stem cells capable of differentiating into osteoblasts, chondrocytes, and adipocytes. They play an important role in alveolar bone regeneration.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Genetics & Heredity
Toshihiro Inubushi, Yuichiro Nakanishi, Makoto Abeid, Yoshifumi Takahata, Riko Nishimura, Hiroshi Kurosaka, Fumitoshi Irie, Takashi Yamashiro, Yu Yamaguchi
Summary: HA degradation mediated by TMEM2 plays a crucial role in neural crest development and the morphogenesis of neural crest derivatives.
Review
Surgery
Nisrina Ekayani Nasrun, Keiko Fujita, Kazumi Chieda, Yoshihiro Abiko, Tsuyoshi Shimo, Kazuki Akizuki
Summary: This case report discusses a patient who underwent orthognathic surgery and presented with suspected irritable bowel syndrome (IBS). After various examinations and surgery, the healing process of the patient's oral mucosa and bone was successful. The relationship between IBS and post-operative healing impairment, as well as the fragility of the oral mucosa, is discussed without a definite conclusion. The importance of reducing risk factors for IBS and maintaining proper perioperative oral hygiene is emphasized.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sayuri Yamamoto, Chihiro Tanikawa, Takashi Yamashiro
Summary: The morphology of the human face varies widely due to genetic and environmental factors. This study focused on the 3D facial morphology of Japanese adults with skeletal Class 1 malocclusion and examined the association between sexual dimorphism and shape variations.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Nisrina Ekayani Nasrun, Akihiko Tanimura, Tsuyoshi Shimo
Summary: Taste sensitivity in humans varies due to differences in the structure of sense-perception organs. Taste perception is caused by chemosensory organs interacting with taste receptors and transmitting signals to the brain. Taste receptors, including TAS1R and TAS2R, are not only found in the oral cavity but also in extraoral sites. They play a role in bone remodeling, and this review provides clinical evidence for their importance.
ORAL SCIENCE INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuka Murata, Chihiro Tanikawa, Yuki Shiraishi, Toshihiro Inubushi, Kana Kono, Hiroshi Kamioka, Takashi Yamashiro
Summary: Masticatory activity affects the skeletal development of the cranial base, particularly leading to morphological changes in the sphenoid bone.
EUROPEAN JOURNAL OF ORTHODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuka Murata, Hiroshi Kurosaka, Takumi Hirose, Makoto Fujiwara, Yoko Miyoshi, Masayo Kagami, Kaori Hara-Isono, Keiichi Ozono, Takashi Yamashiro
Summary: This article describes comprehensive orthodontic treatment for an 11-year-old girl with SRS, achieving improvement in facial profile and occlusion through two phases of treatment. Long-term follow-up is also necessary.
CLINICAL AND INVESTIGATIVE ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chihiro Tanikawa, Yuko Shintaku, Hiroshi Yoshikawa, Takashi Yamashiro
Summary: This study developed a novel method for accurately superimposing an intraoral digital model on CBCT images based on palatal mucosa coated with barium sulphate. It was found that the errors when using CBCT images obtained with barium sulphate coating were significantly smaller than when using uncoated images.
CLINICAL AND INVESTIGATIVE ORTHODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hirotaka Ueda, Naoki Oka, Tsuyoshi Shimo, Akira Sasaki, Takashi Yamashiro, Hiroshi Kamioka
Summary: This article presents the orthognathic treatment of an adult patient with skeletal Class III malocclusion, facial asymmetry, and anterior disc displacement without reduction (ADDwoR) at the right temporomandibular joint (TMJ) using intraoral vertical ramus osteotomy (IVRO). The IVRO procedure successfully corrected the mandibular deviation and improved the symptoms of temporomandibular disorders. The results demonstrate the potential effectiveness of IVRO in addressing facial asymmetry and anterior disc displacement in patients with mandibular deviation.
CLINICAL AND INVESTIGATIVE ORTHODONTICS
(2022)