Article
Biochemistry & Molecular Biology
Junzhi Liang, Yingzhuo Gao, Ziyi Feng, Bowen Zhang, Zhijing Na, Da Li
Summary: Reactive oxygen species (ROS) are produced in mitochondria and play a crucial role in regulating the ovarian cycle through signaling. However, an imbalance between ROS generation and the antioxidant defense system can lead to ovarian diseases. Understanding the mechanisms of ROS generation and homeostasis in the ovary, as well as the pathological effects and potential antioxidant strategies, is important for the development of effective treatments.
Article
Engineering, Environmental
Gwang-Bum Im, Young Geon Kim, In-Seong Jo, Tae Yong Yoo, Sung-Won Kim, Hyun Su Park, Taeghwan Hyeon, Gi-Ra Yi, Suk Ho Bhang
Summary: This study investigated the effects of surfactant-free and surfactant-treated nanoparticles on cell viability and physiology. The results showed that the nanoparticles could scavenge reactive oxygen species and promote cell proliferation and adipogenic differentiation. However, the surfactant-treated nanoparticles exhibited higher cytotoxicity than the surfactant-free nanoparticles after long-term treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Kaysaw Tuy, Lucas Rickenbacker, Anita B. Hjelmeland
Summary: Controlling ROS levels is crucial for regulating tumor biology, especially within the CSC population. The role of ROS under hypoxia in the tumor microenvironment is significant. Metabolic shifts provide survival advantages while reducing damage from oxidative stress.
Article
Chemistry, Multidisciplinary
Naeun Park, Kyoung Sub Kim, Kun Na
Summary: This study presents an approach for manipulating paracrine factors and signaling pathways in adipose-derived stem cells to achieve effective tumor immunotherapy. The method involves precise control of reactive oxygen species concentration and regulation of specific signaling pathways to induce the secretion of inflammatory cytokines and inhibit the secretion of cell growth factors. When injected into a tumor animal model, the modified stem cells autonomously target and accumulate at the tumor site, generating anti-inflammatory factors and reducing angiogenesis growth factors upon laser irradiation, leading to effective melanoma and pancreatic tumor treatment in mice. This technology holds significant promise for the treatment of various diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Endocrinology & Metabolism
Meng Luo, Zhihe Zhao, Jianru Yi
Summary: Diabetes mellitus (DM) is a clinical risk factor for bone diseases, such as osteoporosis and fragility. The osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) is impaired under high glucose conditions, leading to diabetic bone diseases and reducing the therapeutic efficiency of BMSCs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Li-Chern Pan, Nguyen-Le-Thanh Hang, Mamadi M. S. Colley, Jungshan Chang, Yu-Cheng Hsiao, Long-Sheng Lu, Bing-Sian Li, Cheng-Jen Chang, Tzu-Sen Yang
Summary: Photobiomodulation (PBM) has shown the potential to regulate mitochondrial membrane potential, reactive oxygen species, and vesicle transport through single-cell near-infrared laser irradiation.
Article
Engineering, Biomedical
Chao Yu, Dongdong Li, Chenggui Wang, Kaishun Xia, Jingkai Wang, Xiaopeng Zhou, Liwei Ying, Jiawei Shu, Xianpeng Huang, Haibin Xu, Bin Han, Qixin Chen, Fangcai Li, Jianbin Tang, Chengzhen Liang, Nigel Slater
Summary: This study developed a novel amphiphilic copolymer micelle, loaded with lipophilic kartogenin and apocynin, to enhance the survival and differentiation ability of human adipose-derived stem cells for potential therapeutic effects on intervertebral disc degeneration.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Junyuan Sun, Fei Yang, Lianlei Wang, Haichao Yu, Zhijie Yang, Jingjing Wei, Krasimir Vasilev, Xuesong Zhang, Xinyu Liu, Yunpeng Zhao
Summary: Stem cell transplantation is a promising therapeutic method for intervertebral disc degeneration. However, oxidative stress in the degenerated region impairs the efficiency of the treatment. In this study, Coenzyme Q10 was encapsulated in lecithin micelles and successfully delivered to stem cells in vitro and in animal models, providing a potential therapeutic agent for intervertebral disc degeneration.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Seng-Ho Jeon, Hyunju Kim, Jong-Hyuk Sung
Summary: Human embryonic stem cell (hES)-derived mesenchymal stem cells (MSCs) have hair growth-promoting effects, which can be enhanced by hypoxia. The injection of hES-MSCs or conditioned medium (Hyp-CM) cultured under hypoxia (2% O-2) can increase the length of mouse vibrissae, human hair follicles, and the proliferation of human dermal papilla and outer root sheath cells. Fibroblast growth factor 7, interleukin 12B, and teratocarcinoma-derived growth factor 1 are upregulated under hypoxia and co-treatment with these proteins can induce telogen-to-anagen transition and increase hair length. ROS scavenging can attenuate the secretion of growth factors by hES-MSCs under hypoxia.
Article
Toxicology
Carlos Angele-Martinez, Fathima S. Ameer, Yash S. Raval, Guohui Huang, Tzuen-Rong J. Tzeng, Jeffrey N. Anker, Julia L. Brumaghim
Summary: Polyphenolic antioxidants have varying effects on preventing DNA damage and cytotoxicity induced by (CuO)-Cu-NP and H2O2, with some being protective, some having no effect, and some even increasing DNA damage. Additionally, polyphenols can modulate levels of reactive oxygen species (ROS) generated, and protect DNA under oxidative stress conditions.
TOXICOLOGY IN VITRO
(2022)
Article
Biotechnology & Applied Microbiology
Ting Liu, Qianqian Ma, Wenjie Li, Yan Hu, Jun Yang, Qi Yao
Summary: Non-small cell lung cancer (NSCLC) cancer stem cells (CSCs) suppress reductive redox states and ROS levels in non-adherent spheres, while UBQLN1 protein level is positively correlated with patient's survival of lung adenocarcinoma.
Review
Biochemistry & Molecular Biology
Tullia Maraldi, Cristina Angeloni, Cecilia Prata, Silvana Hrelia
Summary: This review highlights the role of NOX-derived ROS in stem cell biology and functions, focusing on the positive and negative effects triggered by the activity of different NOX isoforms. Recent findings on downstream molecular targets of NOX-ROS signaling that can modulate stem cell homeostasis and lineage commitment are discussed, along with implications in ex vivo expansion and in vivo engraftment, function, and longevity. The pivotal role of NOX as a regulator of several stem cell populations is underscored, and further studies on the effects of pharmacological modulation of NOX in human stem cells are deemed imperative.
Article
Engineering, Biomedical
Zhong Liu, Song Guo, Lanlan Dong, Peipei Wu, Kewei Li, Xinhua Li, Xiang Li, Hui Qian, Qiang Fu
Summary: This study found that sEVs have potential therapeutic effects in the treatment of spinal cord injury. By fabricating a novel sEVs-releasing hydrogel, the researchers successfully promoted the recovery of motor function after spinal cord injury and effectively regulated the inflammatory and ROS microenvironment.
MATERIALS TODAY BIO
(2022)
Article
Food Science & Technology
Xiaoting Sun, Yuanyuan Li, Yanqi Lin, Yuanyuan Mei, Lingli Lin, Kuo-Ting Ho, Jialin Zhan, Chaoxiang Chen, Jun Zeng, Jian Li, Jingwen Liu, Guiling Li
Summary: This study found that curcumin can enhance cellular antioxidant capacity and mitochondrial function by downregulating miR-22-3p and targeting CRLS1 gene.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cardiac & Cardiovascular Systems
Wei-Syun Hu, Tung-Sheng Chen, Ka-Hung Cheang, Wei-Yu Liao, Chin-Hsien Chang
Summary: This study found that mesenchymal stem cell transplantation has therapeutic effects on diabetic cardiomyopathy by regulating inflammasome signaling and reducing oxidative stress, leading to improvements in heart tissue structure and function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)