Article
Neurosciences
Karlie N. Fedder-Semmes, Bruce Appel
Summary: Oligodendrocytes produce myelin to insulate and support axons in the vertebrate central nervous system. Akt-mTOR signaling pathway plays a crucial role in promoting myelin sheath growth and stability through regulating translation, highlighting the importance of local translation in controlling myelin sheath growth.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Plant Sciences
Ahyoung Yoo, Young Jin Jang, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Summary: DMBQ was shown to increase skeletal muscle mass and performance by regulating the AKT/mTOR signaling pathway and enhancing mitochondrial function, which might be beneficial for the treatment and prevention of skeletal muscle atrophy.
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Ryuni Kim, Jee Won Kim, Hyerim Choi, Ji-Eun Oh, Tae Hyun Kim, Ga-Yeon Go, Sang-Jin Lee, Gyu-Un Bae
Summary: This study reveals the effects of Ginsenoside Rg5 on muscle differentiation, growth, and prevention of muscle atrophy. Rg5 promotes myogenesis and hypertrophy by activating p38MAPK and Akt/mTOR signaling pathways. This research suggests that Rg5 has potential therapeutic applications in muscle weakness and atrophy.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Arunima Mondal, Shreya Das, Jayeeta Samanta, Santanu Chakraborty, Arunima Sengupta
Summary: Cardiac disease is a common complication of diabetes, characterized by cardiac hypertrophy and fibrosis. YAP1 and FOXM1 have been found to be overexpressed in cardiac tissue under hyperglycemic conditions, leading to cardiomyocyte hypertrophy and increased fibrotic response. The mechanism involves YAP1 activation through reduced ser127 phosphorylation and extensive 0-G1cNAcylation under hyperglycemia, which further activates AKT phosphorylation and inhibits GSK3B, resulting in increased FOXM1 expression.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Pharmacology & Pharmacy
Ruohan Zhang, Serra Ozgen, Hongke Luo, Judith Krigman, Yutong Zhao, Gang Xin, Nuo Sun
Summary: In this study, the researchers investigate the role of Parkin and USP30 in regulating the AKT/mTOR signaling during mitophagy. They found that Parkin inhibits AKT/mTOR signaling, while USP30 antagonizes the activity of Parkin to sustain AKT/mTOR activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
W. E. I. W. E. I. ZHOU, W. E. I. Z. H. E. LIU, D. I. N. G. Y. A. N. ZHOU, A. I. Y. I. N. G. LI
Summary: The ITGB1 gene inhibits cardiomyocyte autophagy and hypertrophy, highlighting its potential as a target for preventing heart disease.
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Article
Biochemistry & Molecular Biology
Martyna Nowacka, Przemyslaw Latoch, Matylda A. Izert, Natalia K. Karolak, Rafal Tomecki, Michal Koper, Agnieszka Tudek, Agata L. Starosta, Maria W. Gorna
Summary: This study proposes an mRNA enrichment strategy based on the RNA-binding properties of human IFIT1, which effectively depletes rRNA while maintaining high quality RNA-seq data with coverage of the protein coding transcriptome. It is a cost-effective and versatile tool for preparing mRNA libraries for various organisms.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Toxicology
Rongzhe Zhu, Xiaochen Liu, Qiupeng Xue, Xiaoru Dong, Tianyi Zhang, Yan Jiang
Summary: This study evaluated the cardiotoxicity of the combined use of mirtazapine (MIR) and ethanol (EtOH). It found that EtOH exacerbated MIR-induced cardiac injury and dysfunction in autophagy. Additionally, knockdown of high mobility group box 1 (HMGB1) contributed to improved autophagy.
TOXICOLOGY LETTERS
(2022)
Article
Plant Sciences
Yao Chen, Lin Li, Cunyu Hu, Xin Zhao, Peng Zhang, Yanxu Chang, Ye Shang, Yafen Pang, Weiqiang Qian, Xianzhe Qiu, Hongxia Zhang, Deqin Zhang, Shukun Zhang, Yuhong Li
Summary: This study investigated the effects and mechanisms of Lingguizhugan decoction (LD) on heart failure (HF). The results showed that LD alleviated cardiac dysfunction by down-regulating CH-related genes and proteins expression, and the AKT and MAPKs signaling pathways were identified as potential targets for LD treatment. LD inhibited p38 and ERK phosphorylated expression levels, and its effects on the AKT-GSK3 beta/mTOR/P70S6K pathway varied at different time points. Additionally, bioactive compounds detected from plasma were predicted to be responsible for LD's effects on HF.
Article
Cardiac & Cardiovascular Systems
Yang Liu, Shuang Li, Zhanqun Gao, Shuangjia Li, Qingyun Tan, Yanmei Li, Dongwei Wang, Qingdong Wang
Summary: Research has shown that IDO1 promotes cardiomyocyte hypertrophy through the PI3k-AKT-mTOR-S6K1 signaling pathway, and inhibiting IDO1 activity can reduce cardiomyocyte hypertrophy and restore cardiac function.
CARDIOVASCULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuheng Jiao, Yanyan Li, Jiayan Zhang, Song Zhang, Yafang Zha, Jian Wang
Summary: This study aimed to investigate the role and mechanism of ribonucleotide reductase M2 subunit (RRM2) in doxorubicin (DOX)-induced cardiotoxicity. The results showed that reduced expression of RRM2 led to increased apoptosis and autophagy in DOX-treated cardiomyocytes. On the contrary, RRM2 overexpression alleviated DOX-induced cardiotoxicity. Mechanistically, RRM2 could regulate DOX-induced cardiotoxicity through the AKT/mTOR signaling pathway.
Article
Nutrition & Dietetics
Quentin Leyrolle, Renata Cserjesi, Maria D. G. H. Mulders, Giorgia Zamariola, Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnee Portheault, Camille Amadieu, Sophie Leclercq, Laure B. Bindels, Audrey M. Neyrinck, Patrice D. Cani, Olli Karkkainen, Kati Hanhineva, Nicolas Lanthier, Pierre Trefois, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Summary: This study examined the differences in psychological and biological characteristics between obese patients with and without binge eating disorder (BED), revealing significant alterations in affect balance, eating behavior, and gut microbiota in BED patients. Additionally, higher levels of certain food contaminants and metabolites were found in BED subjects through metabolomics analysis.
CLINICAL NUTRITION
(2021)
Review
Food Science & Technology
Julie Rodriguez, Marta Olivares, Nathalie M. Delzenne
Summary: Metabolic endotoxemia concept explains how bacterial components passing through the gut barrier can cause inflammation, while nutrition plays a key role in regulating metabolism. The activity of gut microbiota affects metabolic inflammation and obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nicolas Lanthier, Julie Rodriguez, Maxime Nachit, Sophie Hiel, Pierre Trefois, Audrey M. Neyrinck, Patrice D. Cani, Laure B. Bindels, Jean-Paul Thissen, Nathalie M. Delzenne
Summary: Obesity may lead to MAFLD, and severity is linked to muscle and gut microbiota disturbances. Myosteatosis is the strongest factor associated with fibrosis, and the relative abundance of fecal Clostridium sensu stricto is negatively correlated with liver fibrosis.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Audrey M. Neyrinck, Julie Rodriguez, Zhengxiao Zhang, Benjamin Seethaler, Florence Mailleux, Joeri Vercammen, Laure B. Bindels, Patrice D. Cani, Julie-Anne Nazare, Veronique Maquet, Martine Laville, Stephan C. Bischoff, Jens Walter, Nathalie M. Delzenne
Summary: The study analyzed the profile of exhaled breath volatile metabolites (BVM) and gastrointestinal symptoms in healthy volunteers after ingesting maltodextrin versus chitin-glucan. The results showed that a single ingestion of chitin-glucan increased exhaled butyrate and other BVM without inducing significant gastrointestinal discomfort. Targeted analysis highlighted Mitsuokella as a potential genus responsible for certain metabolites in the breath.
Article
Nutrition & Dietetics
Audrey M. Neyrinck, Julie Rodriguez, Zhengxiao Zhang, Benjamin Seethaler, Candido Robles Sanchez, Martin Roumain, Sophie Hiel, Laure B. Bindels, Patrice D. Cani, Nicolas Paquot, Miriam Cnop, Julie-Anne Nazare, Martine Laville, Giulio G. Muccioli, Stephan C. Bischoff, Jens Walter, Jean-Paul Thissen, Nathalie M. Delzenne
Summary: Intake of inulin-type fructans can reduce intestinal inflammation markers in obese patients, increase Bifidobacterium, and have an impact on certain metabolites in feces.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Christelle Knudsen, Audrey M. Neyrinck, Quentin Leyrolle, Pamela Baldin, Sophie Leclercq, Julie Rodriguez, Martin Beaumont, Patrice D. Cani, Laure B. Bindels, Nicolas Lanthier, Nathalie M. Delzenne
Summary: The study showed that indole is effective in reducing liver damage and associated inflammatory responses and macrophage activation in ob/ob mice, mainly through direct effects on the liver rather than adipose tissue or the intestinal barrier.
JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Audrey M. Neyrinck, Julie Rodriguez, Bernard Taminiau, Camille Amadieu, Florent Herpin, Francois-Andre Allaert, Patrice D. Cani, Georges Daube, Laure B. Bindels, Nathalie M. Delzenne
Summary: This study indicates that a synbiotic approach using Bifidobacterium animalis lactis and fructo-oligosaccharides can significantly improve gastrointestinal health and reduce inflammation in middle-aged individuals. While the treatment did not impact mood, quality of life, or gut microbiota composition, it did lead to a significant decrease in plasma proinflammatory cytokines after 30 days of supplementation.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Anastasiya Borsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jerome N. Feige, Markus A. Ruegg, Mihaela Zavolan
Summary: This study utilized phenotypic measurements and RNA-Seq data from mice, rats, and humans to assess the relevance of rodent models for human muscle aging. The findings suggest that rodents can recapitulate some aspects of human sarcopenia, such as mitochondrial changes and inflammatory responses. Additionally, phenotypic measurements like muscle mass were found to be better indicators of muscle health than chronological age in aging-related molecular data analysis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Nutrition & Dietetics
Quentin Leyrolle, Renata Cserjesi, Romane Demeure, Audrey M. Neyrinck, Camille Amadieu, Julie Rodriguez, Olli Kaerkkaeinen, Kati Hanhineva, Nicolas Paquot, Miriam Cnop, Patrice D. Cani, Jean-Paul Thissen, Laure B. Bindels, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Summary: This study evaluated the potential links between serum metabolomics and gut microbiome, and mood disturbances in obese patients. The findings revealed altered levels of microbiota-derived metabolites in obese subjects with mood disturbances, suggesting new targets for tackling mood disorders in this context.
Article
Medicine, General & Internal
Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels, Nathalie M. Delzenne
Summary: This study confirms that increasing physical activity can enhance the metabolic benefits of prebiotic supplementation on the gut microbiota, leading to clinical improvements in obese patients such as decreased BMI, lower liver enzymes and cholesterol levels, and improved glucose tolerance.
Article
Food Science & Technology
Rim Nassar, Barbara Vernus, Gilles Carnac, Gilles Fouret, Benedicte Goustard, Francois Casas, Lionel Tintignac, Isabelle Cassar-Malek, Brigitte Picard, Iban Seiliez, Thomas Brioche, Christelle Koechlin-Ramonatxo, Christelle Bertrand-Gaday, Aline Hamade, Fadia Najjar, Beatrice Chabi, Anne Bonnieu
Summary: Myostatin deficiency leads to increased protein degradation in post-mortem muscle, primarily through enhanced calpain activity. Autophagy, ubiquitin-proteasome, and caspase systems are not upregulated in this process.
Article
Multidisciplinary Sciences
Harimalala Ranaivo, Zhengxiao Zhang, Maud Alligier, Laurie Van den Berghe, Monique Sothier, Stephanie Lambert-Porcheron, Nathalie Feugier, Charlotte Cuerq, Christelle Machon, Audrey M. Neyrinck, Benjamin Seethaler, Julie Rodriguez, Martin Roumain, Giulio G. Muccioli, Veronique Maquet, Martine Laville, Stephan C. Bischoff, Jens Walter, Nathalie M. Delzenne, Julie-Anne Nazare
Summary: This study investigated the effects of chitin-glucan on participants at cardiometabolic risk, showing improvements in postprandial glycemic response and changes in gut microbiota composition. Compared to the control group, CG supplementation had a positive impact, particularly in subjects with higher exhaled hydrogen levels.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Audrey M. Neyrinck, Julie Rodriguez, Zhengxiao Zhang, Julie-Anne Nazare, Laure B. Bindels, Patrice D. Cani, Veronique Maquet, Martine Laville, Stephan C. Bischoff, Jens Walter, Nathalie M. Delzenne
Summary: This study analyzed the breath volatile metabolites (BVM) profile in healthy individuals before and after a 3-week intervention with chitin-glucan (CG), a fermentable dietary fiber. The results showed that the post-prandial state versus fasting state is a key determinant of BVM fingerprint. CG intervention promoted interindividual variations of fasting BVM and decreased or delayed the expiration of most exhaled BVM.
Article
Biology
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rueegg
Summary: Muscle size is regulated by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which controls protein synthesis and breakdown. Paradoxically, while mTORC1 activity is necessary for muscle hypertrophy, its constant activation promotes protein breakdown through the UPS. This study highlights the importance of mTORC1-mediated PKB/Akt inhibition and the role of the UPS in muscle atrophy and proteome integrity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Audrey M. Neyrinck, Julie Rodriguez, Bernard Taminiau, Florent Herpin, Patrice D. Cani, Georges Daube, Laure B. Bindels, Nathalie M. Delzenne
Summary: The study suggests that supplementation of rhubarb extract in middle-aged individuals promotes the growth of beneficial bacteria and short-chain fatty acids in the gut, leading to improved stool consistency and frequency, which contributes to relieving chronic constipation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)