期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 11, 页码 3354-3363出版社
WILEY
DOI: 10.1002/jcb.23265
关键词
TENASCIN; BONE MORPHOGENETIC PROTEIN; WNT; MAPK; OSTEOBLAST; OSTEOCYTE; MECHANOTRANSDUCTION
资金
- UC Davis Clinical and Translational Science Center
- NIH NIA [AG22305]
- NIAMS [R057547]
Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differentiation, bone morphogenetic protein (BMP) and Wnt growth factors, and mechanical loading on tenascin expression in osteogenic cells. Osteogenic differentiation increased tenascin C (TnC), and decreased tenascinW(TnW), expression. Both growth factors and mechanical loading increased both TnC and TnW expression, albeit via distinct signaling mechanisms. Both BMP-2 and Wnt5a induction of tenascin expression were mediated by MAP kinases. These data establish a role for BMP, Wnts, and mechanical loading in the regulation of tenascin expression in osteoblasts. J. Cell. Biochem. 112: 3354-3363, 2011. (C) 2011 Wiley Periodicals, Inc.
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