Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells

CDK Inhibitors: From the Bench to Clinical Trials

(2010) Flavio Rizzolio et al.   CURRENT DRUG TARGETS

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

(2010) Christophe Le Tourneau et al.   EUROPEAN JOURNAL OF CANCER

Cyclin-dependent kinase inhibitors: a survey of recent patent literature

(2010) Hervé Galons et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors

(2010) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Whether to target single or multiple CDKs for therapy? That is the question

(2010) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ki67 in breast cancer: prognostic and predictive potential

(2010) Rinat Yerushalmi et al.   LANCET ONCOLOGY

Pathology of hereditary breast cancer

(2010) Leonard Da Silva et al.   MODERN PATHOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel potent pharmacological cyclin-dependent kinase inhibitors

(2009) Józefa Węsierska-Gądek et al.   Future Medicinal Chemistry

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

(2009) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo

(2009) Leigh C. Murphy et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells

(2008) Józefa Węsierska-Gądek et al.   BIOCHEMICAL PHARMACOLOGY

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS3cervix carcinoma cells

(2008) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Signaling of DNA damage is not sufficient to induce p53 response: (Re)Activation of wt p53 protein strongly depends on cellular context

(2007) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR BIOCHEMISTRY