Article
Biochemistry & Molecular Biology
S. de Frutos, M. Griera, M. Hatem-Vaquero, S. Campillo, E. Gutierrez-Calabres, D. Garcia-Ayuso, M. Pardo, L. Calleros, M. Rodriguez-Puyol, D. Rodriguez-Puyol
Summary: TF has the potential to reduce obesity by modulating the INTB1-ILK axis, altering the expression of adipocyte-related genes, increasing ILK expression and activity, and reducing TG storage in malfunctioning hypertrophied WAT. This study discovers the anti-obesogenic capacity of TF, in addition to its anticoagulant and cardiovascular protective advantages.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Hiromichi Murase, Yoichi Matsuo, Yuki Denda, Keisuke Nonoyama, Tomokatsu Kato, Yoshinaga Aoyama, Yuichi Hayashi, Hiroyuki Imafuji, Kenta Saito, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
Summary: Pancreatic cancer is resistant to chemotherapy and has a poor prognosis. The prognostic factor ILK was found to be upregulated in a gemcitabine-resistant pancreatic cancer cell line. The ILK inhibitor Cpd22 showed antitumor effects in both gemcitabine-sensitive and gemcitabine-resistant cells.
Article
Multidisciplinary Sciences
Isabel M. Martin, Michele M. Nava, Sara A. Wickstroem, Frauke Graeter
Summary: This study investigates the mechanotransducing functions of the essential adhesion component integrin-linked kinase (ILK) using force-probe molecular-dynamics simulations. The results suggest that ATP plays a role in facilitating cellular force generation and migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey
Summary: Developmental genes are often controlled by multiple enhancers with similar specificities, making it difficult to fully understand their function when these regulatory elements are deleted. The authors show that deleting one enhancer in the Pitx1 testbed locus leads to regulatory and cellular changes, resulting in altered cell identities and gene expression levels.
NATURE COMMUNICATIONS
(2021)
Article
Hematology
Jue Wang, Shiva Keshava, Kaushik Das, Richard Kolesnick, Xian-Cheng Jiang, Usha R. Pendurthi, L. Vijaya Mohan Rao
Summary: Our study investigates the impact of sphingomyelin metabolism on TF procoagulant activity and its implications in hemostasis and thrombosis. Results reveal that alterations to sphingomyelin levels affect TF activity and hemostatic/thrombotic processes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Yijie Wang, Hui Zhang, Shiyang Wu, Wanting Wan, Xueping Kang, Bei Gao, Haoyu Shi, Shuyang Zhao, Lin Niu, Rui Zou
Summary: This study investigated the mechanism of proliferation and apoptosis of periodontal ligament cells (PDLCs) through an in vitro model. It was found that the proliferation and apoptosis of PDLCs are dependent on substrate stiffness, with stiffer substrates promoting increased proliferation. Depletion of integrin-linked kinase (ILK) diluted the correlation between PDLC behaviors and substrate stiffness. These findings suggest that ILK plays a significant role in modulating PDLC proliferation and apoptosis and can be a potential target for accelerating orthodontic tooth movement (OTM).
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Immunology
Nobuhiro Nakano, Kazuki Saida, Mutsuko Hara, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Kazumi Kasakura, Takuya Yashiro, Chiharu Nishiyama, Hideoki Ogawa, Jiro Kitaura, Ko Okumura
Summary: The study found that the coexistence of Notch and TGF-beta signaling significantly upregulates the expression of MMC markers, with their signals acting interdependently to induce marker expressions. Notch signaling also upregulates mMCP-1 and mMCP-2 expression levels through epigenetic deregulation of the promoter regions of these genes.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Abigail Cunningham, Maddisen Brown, Jonathan Dresselhuis, Nicole Robinson, Keni Hervie, Michael E. Cox, Julia Mills
Summary: This study investigates a novel cancer drug combination strategy targeting glioblastoma cells. The results demonstrate that combination drug treatment significantly increases cell death and aberrant mitotic division, compared to individual inhibitors.
Review
Genetics & Heredity
Saleh Almasabi, Afsar U. Ahmed, Richard Boyd, Bryan R. G. Williams
Summary: ILK is implicated in inflammation and tumorigenesis in the colon, with potential therapeutic implications in CRC. It may play a role in senescence and immunity, but further research is needed to determine its specific actions in CRC. Triggering immune responses against cancer in CRC through activation of TLRs and combining with ILK inhibition could be a promising approach.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Meng-Shan Tsai, Shun-Hua Chen, Chih-Peng Chang, Yi-Ling Hsiao, Li-Chiu Wang
Summary: ILK reduces the accumulation of H3K9me3 on HSV-1 DNA by reducing SUV39H1 and TRIM28 binding, enhancing virus replication. ILK knockdown decreases TRIM28 phosphorylation, weakening its inhibition on lytic gene transcription. ILK inhibitor suppresses HSV-1 replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Odmaa Bayaraa, Claire K. Inman, Sneha A. Thomas, Fatima Al Jallaf, Manar Alshaikh, Youssef Idaghdour, Louise Ashall
Summary: Hyperglycemia-induced transcriptomic changes in human aortic endothelial cells were analyzed using deep time-series RNA-seq profiling. The study revealed significant pathway activation/inhibition events during the 1-4 hour transition, and identified unique clusters of genes underlying coordinated transcriptional events under high glucose conditions. The results provide insights into the rapid molecular alterations promoting endothelial cell dysfunction.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Jorge Felipe Argenta Model, Matheus Vieira Lima, Renata Ohlweiler, Elaine Sarapio, Everton Lopes Vogt, Debora Santos Rocha, Samir Khal de Souza, Anapaula Sommer Vinagre
Summary: The study found that liraglutide can attenuate metabolic changes induced by orchiectomy in rats, including reducing triglyceridemia and improving glucose metabolism. This suggests that liraglutide may be a promising therapeutic strategy to address disruptions in energy metabolism caused by androgen deficiency.
Article
Immunology
Tahereh Derakhshan, Sachin K. Samuchiwal, Nils Hallen, Lora G. Bankova, Joshua A. Boyce, Nora A. Barrett, K. Frank Austen, Daniel F. Dwyer
Summary: This study identifies distinct subsets of inducible mast cells in C57BL/6 mice that expand and mature during lung inflammation, regulated by a TGF-beta-inducible transcriptional program. The potential for epithelial cells to direct MMC development is also highlighted.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Physiology
Ekaterina K. Selivanova, Dina K. Gaynullina, Olga S. Tarasova
Summary: Hyperthyroidism is associated with a decreased peripheral vascular resistance, potentially due to the vasodilator effects of thyroid hormones (TH). Non-genomic effects of TH on rat skeletal muscle arteries include T3-dependent endothelium-dependent relaxation and T4-dependent endothelium-independent relaxation. T4 exerts a stronger effect on alpha(1)-adrenergic contraction compared to T3, involving suppression of extracellular matrix signaling via integrin alpha v beta 3, ERK1/2, and ILK with subsequent decrease of MLC2 (Ser19) phosphorylation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Rheumatology
Jiaqi Ren, Lin Sun, Xing Sun, Zhenzhen Ma, Xinyu Wang, Zhuo An, Jinxia Zhao
Summary: The prevalence of serum CTGF was significantly higher in RA patients compared to other rheumatic diseases and healthy controls, indicating its potential value as a diagnostic biomarker for RA. CTGF-positive patients had higher levels of anti-CCP antibody, RF, IgG, and IgM, while the presence of ILD in RA patients was associated with a higher positivity rate of serum CTGF. Further studies are needed to fully understand the diagnostic performance of CTGF in RA.
CLINICAL RHEUMATOLOGY
(2021)