Article
Nutrition & Dietetics
Katherine M. Weh, Yun Zhang, Connor L. Howard, Amy B. Howell, Jennifer L. Clarke, Laura A. Kresty
Summary: This study investigated the inhibitory effects of cranberry polyphenols on premalignant Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) cell lines. The results showed that cranberry polyphenols, particularly C-PAC, were more effective at inducing cell death in these cell lines compared to a combination of anthocyanins, flavonoids, and glycosides (AFG). The analysis of protein pathways revealed previously unidentified mechanisms by which cranberry polyphenols exert their cancer inhibitory effects. These findings provide new insights into the potential use of cranberry constituents as preventive agents for EAC.
Article
Multidisciplinary Sciences
Chun-Xiang Cai, Shu-Lian Li, Hui-Ling Lin, Zi-Han Wei, Lin Xie, Li-Rong Lin, Jian-Jun Niu, Tian-Ci Yang
Summary: This study found that the Treponema pallidum protein Tp0136 enhances the expression of MMP1 in human dermal vascular smooth muscle cells (HDVSMCs) through the PI3K, MAPK, and NF-kappa B signaling pathways, leading to an imbalance of MMPs/TIMPs and potentially contributing to the early spread and pathogenesis of syphilis.
Review
Urology & Nephrology
Roberto Silvestri, Vanessa Nicoli, Priyadarsini Gangadharannambiar, Francesco Crea, Martin D. Bootman
Summary: This article provides an overview of the role of calcium in driving prostate cancer and discusses current therapies targeting calcium signalling to treat this malignancy.
NATURE REVIEWS UROLOGY
(2023)
Review
Chemistry, Medicinal
Muskan Bhatia, Mihir Bhalerao, Natalia Cruz-Martins, Dileep Kumar
Summary: Cancer is the second-leading cause of death worldwide, and while effective treatments are available, they often come with severe side effects. Researchers are now focusing on finding anticancer therapies with minimal side effects, with phytochemicals such as curcumin gaining attention as potential options.
PHYTOTHERAPY RESEARCH
(2021)
Article
Oncology
Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia R. Kafer, Samuel Rogers, Phuc-Loi Luu, Anthony J. Cesare, Susan J. Clark, Phillippa C. Taberlay
Summary: The study found that BRG1 is overexpressed in prostate cancer and mainly affects global transcription programs by down-regulating gene expression, with most downregulated genes related to proliferation. Depletion of BRG1 results in G1 arrest.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolo Pernigoni, Jan Hendrik Ruschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Attanasio, Marco Losa, Holger Moch, Peter Wild, Gerda Egger, Andrea Alimonti
Summary: Metastasis in prostate cancer is influenced by senescence with TIMP1 acting as a molecular switch. Elimination of senescent cells can impair tumor metastasis.
Article
Biochemistry & Molecular Biology
Juliana A. Camargo, Nayara I. Viana, Ruan Pimenta, Vanessa R. Guimaraes, Gabriel A. dos Santos, Patricia Candido, Vitoria Ghazarian, Poliana Romao, Iran A. Silva, Alexander Birbrair, Miguel Srougi, William C. Nahas, Katia R. Leite, Ericka B. Trarbach, Sabrina T. Reis
Summary: CRISPR-Cas9 genome editing provides new possibilities for investigating prostate cancer, as it can effectively knockout oncogenes and reduce tumor resistance. In this study, the MMP9 and miR-21 targets in PCa were evaluated using the CRISPR-Cas9 system. The edited cells showed reduced cell proliferation, invasion, and increased apoptosis, suggesting that CRISPR-Cas9-edited cells of miR-21 and MMP9 can impede the evolution of PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Rima Sedbare, Ginta Jakstane, Valdimaras Janulis
Summary: In this study, the content of secondary metabolites in introduced and bred large cranberry fruits were analyzed qualitatively and quantitatively. The highest levels of anthocyanins, proanthocyanidins, flavonols, and triterpenoids were found in different cranberry cultivars. These results are important for cultivar selection, cranberry raw material preparation, and the effectiveness of cranberry supplements and preparations.
Review
Biochemistry & Molecular Biology
Boris V. Nemzer, Fadwa Al-Taher, Alexander Yashin, Igor Revelsky, Yakov Yashin
Summary: Cranberries are a healthy food rich in bioactive compounds with antioxidant properties. They are abundant in polyphenols and have various health benefits, including prevention of urinary tract inflammation, cardiovascular diseases, oncology diseases, type 2 diabetes, metabolic syndrome, obesity, tooth decay, periodontitis, and Helicobacter pylori bacteria in the stomach.
Review
Cell Biology
Valeriya Pankova, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Soft tissue sarcomas are rare cancers of mesenchymal origin that produce large quantities of extracellular matrix components, which play a key role in sarcomagenesis through interactions with cell adhesion receptors. Studies have identified key ECM components and their important role in sarcomagenesis, highlighting the need for more comprehensive analyses to identify new drug targets and prognostic biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francis Feldman, Mireille Koudoufio, Ramy El-Jalbout, Mathilde Foisy Sauve, Lena Ahmarani, Alain Theophile Sane, Nour-El-Houda Ould-Chikh, Thierry N'Timbane, Natalie Patey, Yves Desjardins, Alain Stintzi, Schohraya Spahis, Emile Levy
Summary: The study investigates the efficacy of cranberry proanthocyanidins (PACs) in improving metabolic syndrome (MetS) and liver complications. The results show that PACs can alleviate obesity, insulin resistance, and hyperlipidemia, and reduce oxidative stress and inflammation. Additionally, PACs improve fatty liver disease and inhibit liver gluconeogenesis.
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Noemi Eiro, Antonio Medina, Luis O. Gonzalez, Maria Fraile, Ana Palacios, Safwan Escaf, Jesus M. Fernandez-Gomez, Francisco J. Vizoso
Summary: Men usually undergo a prostate needle biopsy after abnormal levels of serum prostate-specific antigen (PSA) or digital rectal exam. However, the traditional sextant technique misses a significant portion of cancers. To address this issue, the study evaluated the expression of matrix metalloproteases (MMPs) in prostate tissues using machine learning techniques. The findings showed that MMPs have higher expression in prostate cancer (PCa) compared to benign prostate tissues, suggesting their potential contribution to PCa diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Behavioral Sciences
Robert A. Deziel, Catherine L. Ryan, R. Andrew Tasker
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Neurosciences
Nina Weishaupt, Angela Zhang, Robert A. Deziel, R. Andrew Tasker, Shawn N. Whitehead
FRONTIERS IN NEUROSCIENCE
(2016)
Article
Neurosciences
Robert A. Deziel, R. Andrew Tasker
ACTA NEUROPSYCHIATRICA
(2018)
Article
Oncology
Malcolm A. MacLean, Bradley E. Scott, Bob A. Deziel, Melissa C. Nunnelley, Anne M. Liberty, Katherine T. Gottschall-Pass, Catherine C. Neto, Robert A. R. Hurta
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2011)
Article
Biochemistry & Molecular Biology
Bob Deziel, James MacPhee, Kunal Patel, Adriana Catalli, Marianna Kulka, Catherine Neto, Katherine Gottschall-Pass, Robert Hurta
Article
Behavioral Sciences
Robert A. Deziel, R. Andrew Tasker
BEHAVIORAL NEUROSCIENCE
(2017)