期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 110, 期 5, 页码 1046-1057出版社
WILEY
DOI: 10.1002/jcb.22629
关键词
FGF; FGFR; SKELETAL DEVELOPMENT; ENDOCHONDRAL OSSIFICATION; GROWTH PLATE
资金
- Shutters Hospitals for Children
The mammalian skeleton developments and grows through two complementary pathways. membranous ossification, which gives rise to the calvarial bones and distal clavicle, and endochondral ossification, which is responsible for the bones of the limbs, girdles, vertebrae, face and base of the skull and the medial clavicle Fibroblast growth factors (FGFs) and their cognate FGF receptors (FGFRs) play important roles in regulating both pathways However. I he details of how FGF signals are initiated, propagated and modulated within the developing skeleton are only slowly emerging This prospect will focus on the current understanding of these events during endochondral skeletal development with special attention given to concepts that have emerged in the past few years. J Cell Biochem. 110: 1046-1057, 2010 (C) 2010 Wiley-Liss, Inc
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