PRL-3 phosphatase and cancer metastasis

Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice

(2010) Ke Guo et al.   CANCER BIOLOGY & THERAPY

PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly

(2010) Yuhong Liu et al.   CANCER BIOLOGY & THERAPY

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase

(2010) Haihe Wang et al.   CANCER CELL

Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression

(2010) S. Hardy et al.   CANCER RESEARCH

Poly(C)-binding proteins as transcriptional regulators of gene expression

(2009) Hack Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enzyme Activity of Phosphatase of Regenerating Liver Is Controlled by the Redox Environment and Its C-Terminal Residues

(2009) Andria L. Skinner et al.   BIOCHEMISTRY

2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: A successful approach for the identification of kinase/phosphatase targets

(2009) Laura Orsatti et al.   ELECTROPHORESIS

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2

(2009) Sang-Hyun Min et al.   LIFE SCIENCES

PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts

(2009) David G Molleví et al.   Molecular Cancer

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

(2009) Lirong Peng et al.   Molecular Cancer

An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells

(2009) L. Wang et al.   MOLECULAR PHARMACOLOGY

PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer

(2009) Jian Ming et al.   PATHOLOGY

Phosphatase of Regenerating Liver-3 Localizes to Cyto-Membrane and Is Required for B16F1 Melanoma Cell Metastasis In Vitro and In Vivo

(2009) Ran Song et al.   PLoS One

Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening

(2008) Hwangseo Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PRL PTPs: mediators and markers of cancer progression

(2008) Darrell C. Bessette et al.   CANCER AND METASTASIS REVIEWS

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage

(2008) S. Daouti et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Over-expression of phosphatase of regenerating liver-3 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

(2008) Jun Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression

(2008) Eri Mizuuchi et al.   INTERNATIONAL JOURNAL OF CANCER

Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase

(2008) Fubo Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of molecular determinants of PRL-3

(2008) Mihaela Pascaru et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation

(2008) Shashwati Basak et al.   MOLECULAR CELL

New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53

(2008) S-H Min et al.   ONCOGENE

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3

(2007) Eleonora Forte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells

(2007) U.-M. Fagerli et al.   BLOOD