Review
Biochemistry & Molecular Biology
Dongliang Hu, Lijuan Wei, Weibiao Liao
Summary: This review discusses the interaction between brassinosteroids (BRs) and small-molecule compounds (SMCs) in plant growth, development, and stress responses, highlighting how they promote plant development and alleviate stress damage by modulating the antioxidant system, photosynthetic capacity, and carbohydrate metabolism.
Article
Chemistry, Multidisciplinary
Tao Tang, Biao Huang, Feng Liu, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: This study proposes a strategy for the efficient delivery of nanoagents into tumors by regulating the NO-mediated tumor microenvironment. In mouse experiments, quantum dots and liposomes were encapsulated and loaded with L-arginine to continuously generate NO in the tumor, which activated metalloproteinases in the tumor microenvironment, degraded collagen I, and improved the accumulation and therapeutic efficacy of liposomes in the tumor.
Article
Chemistry, Analytical
Yang Tian, Senyao Liu, Wenwen Cao, Peng Wu, Zhaoming Chen, Hu Xiong
Summary: In this study, an activatable near-infrared II (NIR-II) fluorescent probe (IR-990) was developed for real-time detection of endogenous H2O2 in the progression of drug-induced liver injury (DILI). The probe exhibited intense NIR-II fluorescence in the presence of H2O2, and showed high sensitivity and selectivity in vitro and in vivo experiments.
ANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Cheng Ren, Yibo Xu, Hongliang Liu, Zhimeng Wang, Teng Ma, Zhong Li, Liang Sun, Qiang Huang, Kun Zhang, Chengcheng Zhang, Yu Cui, Qian Wang, Yao Lu
Summary: This study found that RUNX2 is involved in the regulation of osteoblast autophagy and differentiation by mediating autophagy-related and osteoblast differentiation-related genes/proteins, as well as the p38MAPK signaling pathway.
Review
Plant Sciences
Francisco J. Corpas, Marta Rodriguez-Ruiz, Maria A. Munoz-Vargas, Salvador Gonzalez-Gordo, Russel J. Reiter, Jose M. Palma
Summary: Melatonin plays a crucial role in fruit ripening by interacting with nitric oxide and hydrogen peroxide, expanding the regulatory networks of these molecules.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Christina Krueger, Anne Joerns, Jonas Kaynert, Markus Waldeck-Weiermair, Thomas Michel, Matthias Elsner, Sigurd Lenzen
Summary: Aquaporin-8 (AQP8) is a peroxiporin protein expressed in the mitochondrial and plasma membranes of pancreatic beta-cells. AQP8 knockdown cells exhibit increased sensitivity to proinflammatory cytokines, leading to enhanced oxidative stress and decreased cell viability due to decreased nitric oxide (NO center dot) generation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Agnieszka Zembron-Lacny, Edyta Wawrzyniak-Gramacka, Anna Ksiazek, Aleksandra Zagrodna, Wieslaw Kopec, Malgorzata Slowinska-Lisowska
Summary: Intense physical exercise leads to increased production of reactive oxygen and nitrogen species. This study examined the effects of dipeptide intake combined with exercise on the oxi-antioxidant response. The results showed that dipeptide intake led to a significant increase in the NO/H2O2 ratio after exercise, indicating enhanced antioxidant status. Additionally, dipeptides were found to reduce C-reactive protein levels, suggesting their anti-inflammatory properties. These findings suggest that dipeptides have potential in reducing oxidative stress and inflammation in physically active individuals.
Article
Biochemistry & Molecular Biology
Volodymyr Lushchak, Oleh Lushchak
Summary: In living organisms, most oxygen is reduced to water through four-electron reduction, but a small percentage is reduced through one-electron mechanisms to produce reactive oxygen and nitrogen species. These species interact with various components of living organisms, leading to diverse effects on biological systems.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Haiying Liang, Fei Peng, Yingfeng Tu
Summary: Micro/nanomotors are micro/nanoscale devices that can perform complex tasks by converting various energy sources into mechanical motion. Recent studies have utilized the byproducts generated by micro/nanomotors for active therapy in an environmentally friendly manner, showing great potential and prospects.
Review
Plant Sciences
Faisal Zulfiqar, Muhammad Nafees, Jianjun Chen, Anastasios Darras, Antonio Ferrante, John T. Hancock, Muhammad Ashraf, Abbu Zaid, Nadeem Latif, Francisco J. Corpas, Muhammad Ahsan Altaf, Kadambot H. M. Siddique
Summary: Salt stress severely limits crop productivity globally, and its effects are worsened by climate change. Plant priming, using specific chemical agents, has shown promise in enhancing plant tolerance to salt stress. This review summarizes the current knowledge on various molecules/compounds that can potentially enhance the salinity tolerance of crop plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Materials Science, Biomaterials
Yuchu He, Cong Cong, Shuxian Zhao, Zhuo Li, Desong Wang, Jianmin Gu, Lanxiang Liu, Dawei Gao
Summary: The study developed an intelligent nano-platform integrating diagnosis and treatment, using phototherapy technology to reshape GME and achieve good anti-tumor effects, aiming to provide an innovative and reasonable strategy for the development of tumor treatment.
BIOMATERIALS SCIENCE
(2021)
Review
Cell Biology
Wojciech Pokora, Szymon Tulodziecki, Agnieszka Dettlaff-Pokora, Anna Aksmann
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play regulatory roles in the development of higher plants, algae, and animals. In green cells, the redox potential regulates growth rate. Hydrogen peroxide and nitric oxide directly participate in algal cell development by regulating the expression of proteins involved in the cell cycle. This regulation involves the interaction of these signaling molecules with redox-sensitive transcription factors and signaling pathways. This paper aims to elucidate the involvement of hydrogen peroxide and nitric oxide in algal cell cycle regulation and evaluate their commercial applicability.
Article
Biochemistry & Molecular Biology
Indy Bui, Stavroula Baritaki, Massimo Libra, Apostolos Zaravinos, Benjamin Bonavida
Summary: Therapeutic strategies for cancer treatment have made significant progress, but not all cancer types respond to these novel therapies, and resistance mechanisms play a major role in this failure. Overexpression of inducible nitric oxide synthase (iNOS) has been found in many cancer types, and it is suggested that iNOS/nitric oxide (NO) plays a role in resistance regulation. iNOS/NO regulates the expression of anti-apoptotic gene products through various mechanisms. Targeting iNOS may be a promising approach to reverse resistance.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Chemistry, Physical
Aaditya S. Deshpande, Wayne Muraoka, Silvana Andreescu
Summary: Electrochemical sensors are effective in detecting reactive oxygen and nitrogen species in biological processes. Recent developments in microelectrode and electrode materials show promise in studying drug efficacy, mitochondrial distress, and endothelial dysfunction. Challenges and opportunities in applying this methodology to study pathophysiology associated with various diseases are discussed.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Plant Sciences
Shaoying Ma, Jinyu Bao, Yaqi Lu, Xu Lu, Peng Tian, Xiaoling Zhang, Jie Yang, Xiaotong Shi, Zhihui Pu, Sheng Li
Summary: This study found that melatonin regulates the synthesis of anti-cancer compounds sulforaphane and glucoraphanin, as well as the synthesis of NO and H2O2. The treatment with melatonin increased the yield of sulforaphane and glucoraphanin, and the content of NO and H2O2 were regulated. In addition, the study also found that the inhibition of NO synthesis reduced the yield of sulforaphane and glucoraphanin, and melatonin could alleviate this reduction by regulating NO synthesis-related enzymes.
Article
Endocrinology & Metabolism
Ta-Wei Tai, Chia-Chun Li, Chun-Feng Huang, Wing P. Chan, Chih-Hsing Wu
Summary: This nationwide study in Taiwan showed that anti-osteoporosis treatment after hip fracture surgery was associated with lower all-cause mortality. Patients who received longer durations of treatment had even lower mortality rates. Postoperative treatment for osteoporosis is crucial for improving outcomes in hip fracture patients.
Review
Radiology, Nuclear Medicine & Medical Imaging
Ting-Wan Kao, Kuo-Hua Lee, Wing P. Chan, Kang-Chih Fan, Che-Wei Liu, Yu-Chen Huang
Summary: The meta-analysis found that continuing metformin during contrast medium administration does not increase the risk of contrast-induced acute kidney injury, lactic acidosis, or deterioration in renal function in diabetic patients. However, the limited quality of included studies may compromise the strength of evidence provided in this analysis.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ping-Huei Tsai, Chin-Chean Wong, Wing P. Chan
Summary: This study validated a 2D radial T2* mapping method for revealing subtle alterations in the menisci of patients with knee osteoarthritis (OA). The results showed that the radial T2* mapping method provided better discrimination than the conventional method. It was found that the T2* values in the menisci were significantly higher in the OA group compared to the control group, and there were correlations between the T2* values and the Lequesne index.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Muhammad Adeel, Chien -Hung Lai, Bor-Shing Lin, Wing P. Chan, Jian-Chiun Liou, Chun-Wei Wu, Chih-Wei Peng
Summary: This study aimed to investigate the effects of different waveforms using paired stimulations with bicycling in subjects with a chronic spinal cord injury (SCI).
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Chang-Le Chen, Ming-Che Kuo, Pin-Yu Chen, Yu-Hung Tung, Yung-Chin Hsu, Chi-Wen Christina Huang, Wing P. Chan, Wen-Yih Isaac Tseng
Summary: This study found that brain age gap (BAG) can serve as a mediator linking modifiable risk factors to cognitive functioning, suggesting its potential role in the management of cognitive aging and dementia.
NEUROBIOLOGY OF AGING
(2022)
Article
Oncology
Vu Pham Thao Vy, Melissa Min-Szu Yao, Nguyen Quoc Khanh Le, Wing P. Chan
Summary: Breast cancer is the most common cancer among women, and it can be classified into non-invasive and invasive types based on whether it has spread. Early identification of breast cancer types allows for more options of less invasive therapies. In this study, a machine learning classification model was developed to differentiate between ductal carcinoma in situ (DCIS) and minimally invasive breast cancer (MIBC), using clinical characteristics, mammography findings, ultrasound findings, and histopathology features. Five most important features were identified in the model.
Article
Medicine, General & Internal
Melissa Min-Szu Yao, Hao Du, Mikael Hartman, Wing P. Chan, Mengling Feng
Summary: This study aimed to develop a novel AI model algorithm using graph convolution approach to automatically detect and classify various patterns of calcification distribution in mammographic images. The proposed model achieved superior performance in predicting breast calcification patterns compared to baseline models, based on the analysis of 292 patients with diagnosed breast cancer.
Editorial Material
Orthopedics
Wing P. Chan, Melissa Min-Szu Yao, Russell Oliver Kosik
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chung-Chien Huang, Fransisca Fortunata Effendi, Russell Oliver Kosik, Wen-Jeng Lee, Li-Jen Wang, Chun-Jung Juan, Wing P. Chan
Summary: This population-based study aimed to collect, analyze, and summarize the long-term trends in medical imaging use in Taiwan. The results showed that CT and MRI use has sharply increased in the past two decades, especially in the older age group, but the growth rates have slowed in recent years. The increase in imaging use has been associated with improved clinical outcomes, including higher life expectancy and reduced mortality rates, although further assessment is needed to demonstrate a direct link with imaging.
INSIGHTS INTO IMAGING
(2023)
Article
Medicine, General & Internal
Chun-Feng Huang, Jung-Fu Chen, Ian R. Reid, Wing P. Chan, Peter Robert Ebeling, Bente Langdahl, Shih-Te Tu, Toshio Matsumoto, Ding-Cheng Chan, Yoon-Sok Chung, Fang-Ping Chen, E. Michael Lewiecki, Keh-Sung Tsai, Rong-Sen Yang, Seng Bin Ang, Ko-En Huang, Yin-Fan Chang, Chung-Hwan Chen, Joon-Kiong Lee, Hsin-I Ma, Weibo Xia, Ambrish Mithal, David L. Kendler, Cyrus Cooper, Jawl-Shan Hwang, Chih-Hsing Wu
Summary: Postmenopausal women are at a high risk of osteoporotic fractures due to rapid bone loss. To prevent this, experts in the Asia-Pacific region have developed a set of statements for the prevention of fractures in postmenopausal women. They advocate for reimbursement of pharmaceutical therapy for women with a high risk of fractures and emphasize the need for more clinical experience and data to improve intervention strategies.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Wei-Hsiang Tseng, Han-Wei Huang, Chia-Chun Li, Chin-Sung Chang, Wing P. Chan, Kong-Pin Lin, Chih-Hsing Wu
Summary: This study investigated the epidemiological characteristics of hereditary amyloid transthyretin (ATTRv) amyloidosis with polyneuropathy in Taiwan using data from the Taiwan National Health Insurance Research Database. The annual incidence and prevalence rates of the disease were relatively low in Taiwan, with a male predominance and a mean age at validation of 62.75 years. Early intervention is crucial for improving the survival rate of patients with this disease.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Computer Science, Information Systems
Hao Du, Melissa Min-Szu Yao, Siqi Liu, Liangyu Chen, Wing P. Chan, Mengling Feng
Summary: The morphology and distribution of microcalcifications are important descriptors for diagnosing breast cancer based on mammograms. However, manual characterization of these descriptors is challenging and time-consuming, and there is a lack of effective automatic solutions. This study proposes a multi-task deep graph convolutional network (GCN) method to automatically characterize the morphology and distribution of microcalcifications. The method transforms the characterization into a node and graph classification problem and learns representations concurrently. The proposed method shows significant improvements compared to baseline models, indicating the potential of using GCNs for more robust understanding of medical images.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fransisca Fortunata Effendi, Chung-Chien Huang, Wing P. P. Chan
INSIGHTS INTO IMAGING
(2023)
Article
Endocrinology & Metabolism
John J. Carey, E. Erjiang, Tingyan Wang, Lan Yang, Mary Dempsey, Attracta Brennan, Ming Yu, Wing P. Chan, Bryan Whelan, Carmel Silke, Miriam O'Sullivan, Bridie Rooney, Aoife McPartland, Grainne O'Malley
Summary: Osteoporosis is a common disease that has a significant impact on individuals, healthcare systems, and society. Diagnostic criteria using bone density measurements help understand the epidemiology of the disease and identify those at risk, which is crucial for clinical practice and public health policies.
Article
Medicine, General & Internal
Melissa Min-Szu Yao, Vu Pham Thao Vy, Tony Hsiu-Hsi Chen, Hsian-He Hsu, Giu-Cheng Hsu, Cindy S. Lee, Li-Ju Lin, Shu-Li Chia, Chao-Chun Wu, Wing P. Chan, Amy Ming-Fang Yen
Summary: The breast cancer screening program in Taiwan has shown positive outcomes by increasing the screening population, improving the 10-year survival rate, and reducing the recall rate through the participation of young women, the use of mobile units, and the implementation of a quality assurance program.
