Article
Chemistry, Medicinal
Seung-Hong Lee, Mihyang Kim, Mi Hwa Park
Summary: The study demonstrated that DPHC from Ishige okamurae has protective effects against oxidative damage in osteoblastic cells induced by H2O2 through the BMP2/Runx2 signaling pathway, improving cellular functions and promoting osteoblast differentiation. DPHC also reduced the expression levels of bone resorption-promoting factors and inhibited the generation of reactive oxygen species induced by oxidative stress.
Article
Nutrition & Dietetics
Yu Jin Hwang, Hye-Jeong Hwang, Hyunseo Go, Nayeong Park, Kyung-A Hwang
Summary: Sword bean and sword bean pod extracts can promote osteoblast differentiation and increase osteoblast proliferation and activity.
Article
Biochemistry & Molecular Biology
Yuka Sasaki, Ryusuke Nakatsuka, Takuma Inouchi, Mitsuko Masutani, Tadashige Nozaki
Summary: Inhibition of PARG protein activity accelerates osteoblast differentiation in MC3T3-E1 cells, providing potential therapeutic benefits for metabolic bone diseases such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yu Chen, Yuwei Cai, Chunxiang Chen, Mengting Li, Lingdan Lu, Zhongxiang Yu, Shuqiang Wang, Lei Fang, Shengming Xu
Summary: This study evaluated the osteotoxicity of polychlorinated biphenyls in murine osteoblastic cells and found that oxidative stress plays a crucial role. The results showed that exposure to polychlorinated biphenyls reduced calcium homeostasis, osteoblast differentiation, and bone formation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chunli Wang, Songcai Liu, Jiaxin Li, Yunyun Cheng, Zhaoguo Wang, Tianqi Feng, Guanhong Lu, Siyao Wang, Jie Song, Peijun Xia, Linlin Hao
Summary: The study demonstrates that let-7e-5p promotes osteoblast differentiation by regulating the JAK2/STAT5 pathway and inhibiting SOCS1 expression in MC3T3-E1 cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Pengli Liu, Yilong Cui, Menglin Liu, Bonan Xiao, Jian Zhang, Wanyue Huang, Xuliang Zhang, Miao Song, Yanfei Li
Summary: The study revealed that activation of mitophagy can protect MC3T3-E1 cells from Al-induced functional damage, as evidenced by improved cell viability, cellular calcium and phosphorus contents, and gene expression of collagen I, osteocalcin, and bone alkaline phosphatase.
Article
Food Science & Technology
Lalita Chotphruethipong, Thunwa Binlateh, Pilaiwanwadee Hutamekalin, Rotimi E. Aluko, Surapun Tepaamorndech, Bin Zhang, Soottawat Benjakul
Summary: The study demonstrates that hydrolyzed collagen derived from defatted sea bass skin can promote proliferation and differentiation of preosteoblast cells, enhance alkaline phosphatase activity and mineralization, increase calcium depositions, and elevate the expressions of RUNX2 and p-Akt, suggesting its potential as a functional ingredient for promoting bone strength.
Article
Biochemistry & Molecular Biology
Xinyan Liu, Ru Song, Rongbian Wei, Baoding Zhao, Yurou Chu
Summary: In this study, a VD3-rich extract from shrimp processing by-products was prepared and its effects on bone health were investigated. The extract showed potential in promoting the proliferation and differentiation of bone cells and improving bone remodeling in VD-deficient mice. These findings suggest that the VD3-rich extract could be used to alleviate osteoporosis or promote bone health.
Article
Plant Sciences
Ming-Shi Ren, Hui-Hui Xie, Yu Ding, Zi-Han Li, Bo Liu
Summary: This study aimed to determine whether the serum containing EXD promotes the proliferation and differentiation of osteoblasts through the regulation of BK channel.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen
Summary: The study demonstrated that inhibition of miR-340-5p facilitated osteogenic differentiation by regulating RUNX2 in both rat models and cell experiments, providing potential targeted therapeutic strategies for Diabetic Osteoporosis.
Article
Environmental Sciences
Wenhui Mei, Dan Song, Zhidi Wu, Li Yang, Panpan Wang, Ronghua Zhang, Xiaofeng Zhu
Summary: Resveratrol (RES) is a natural polyphenolic compound that promotes osteoblast differentiation and protects them from cadmium-induced damage. Studies show that pretreatment with RES alleviates cadmium-induced inhibition of osteogenic differentiation by modulating signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Joo Hyun Jang, Singeun Kim, Hyun Jung Lee, Hyung Joo Suh, Kyungae Jo
Summary: The study demonstrated that WPH significantly increased alkaline phosphatase activity and calcium deposition, while upregulating factors related to osteoblast differentiation. Furthermore, in rats administered with a high dose of WPH, significant increases were observed in ALP and IGF-1 levels, tibia length, and growth plate height, indicating a growth-promoting effect on bone.
Article
Cell Biology
Meiyu Piao, Sung Ho Lee, Yuankuan Li, Joong-Kook Choi, Chang-Yeol Yeo, Kwang Youl Lee
Summary: This study reveals the positive impact of CypE on osteoblast differentiation by enhancing the transcriptional activity of Runx2 through its PPIase activity. The involvement of the Akt signaling pathway in CypE's function in osteoblast differentiation is also identified.
Article
Biochemistry & Molecular Biology
Baixiang Wang, Jiakang Yang, Lijie Fan, Yu Wang, Chenqiu Zhang, Huiming Wang
Summary: The study demonstrated that benidipine (BD) promotes the proliferation and osteogenic differentiation of MC3T3-E1 preosteoblast cells, possibly through the BMP2/Smad and OPG/RANKL/RANK pathways. The results confirmed the dual therapeutic potential of BD in hypertensive elderly patients with poor skeletal conditions.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Chemistry, Physical
Yingzi Zhang, Xu Lingling, Zhuo Liu, Xi Cui, Zhuo Xiang, Jinyu Bai, Dongjie Jiang, Jiangtao Xue, Chan Wang, Youxi Lin, Zhe Li, Yizhu Shan, Yuan Yang, Lin Bo, Zhou Li, Xiaozhong Zhou
Summary: The use of a biomechanical-energy-driven shape memory piezoelectric nanogenerator can promote osteogenic differentiation. Pulsed direct current effectively enhances the proliferation and calcium ion increase of preosteoblasts, and improves ALP activity. Ultimately, this method can promote calcium deposition, extracellular matrix mineralization, and osteogenesis.
Article
Multidisciplinary Sciences
Marcelo A. Catalan, Yusuke Kondo, Gaspar Pena-Munzenmayer, Yasna Jaramillo, Frances Liu, Sooji Choi, Edward Crandall, Zea Borok, Per Flodby, Gary E. Shull, James E. Melvin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Cell & Tissue Engineering
Changgong Li, Min Li, Sha Li, Yiming Xing, Chang-Yo Yang, Aimin Li, Zea Borok, Stijn De langhe, Parviz Minoo
Article
Biochemistry & Molecular Biology
Per Flodby, Yong Ho Kim, LaMonta L. Beard, Danping Gao, Yanbin Ji, Hidenori Kage, Janice M. Liebler, Parviz Minoo, Kwang-Jin Kim, Zea Borok, Edward D. Crandall
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Hovhannes J. Gukasyan, Tomomi Uchiyama, Kwang-Jin Kim, Carsten Ehrhardt, Sharon K. Wu, Zea Borok, Edward D. Crandall, Vincent H. L. Lee
PHARMACEUTICAL RESEARCH
(2017)
Article
Physiology
Arnold Sipos, Kwang-Jin Kim, Robert H. Chow, Per Flodby, Zea Borok, Edward D. Crandall
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Danielle R. Little, Kamryn N. Gerner-Mauro, Per Flodby, Edward D. Crandall, Zea Borok, Haruhiko Akiyama, Shioko Kimura, Edwin J. Ostrin, Jichao Chen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Critical Care Medicine
Zea Borok, Masafumi Horie, Per Flodby, Hongjun Wang, Yixin Liu, Sivagini Ganesh, Amy L. Firth, Parviz Minoo, Changgong Li, Michael F. Beers, Amy S. Lee, Beiyun Zhou
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Physiology
Alessandra Castaldi, Masafumi Horie, Megan E. Rieger, Mickael Dubourd, Mitsuhiro Sunohara, Kusum Pandit, Beiyun Zhou, Ite A. Offringa, Crystal N. Marconett, Zea Borok
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Genetics & Heredity
Daniel J. Mullen, Chunli Yan, Diane S. Kang, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Peggy J. Farnham, Ite A. Offringa, Suhn Kyong Rhie
Article
Biochemistry & Molecular Biology
Daisy Flores Rangel, Louis Dubeau, Ryan Park, Priscilla Chan, Dat P. Ha, Mario A. Pulido, Daniel J. Mullen, Ivetta Vorobyova, Beiyun Zhou, Zea Borok, Ite A. Offringa, Amy S. Lee
Summary: Lung cancer is the leading cause of cancer mortality worldwide, with KRAS being the most commonly mutated gene in lung adenocarcinoma. Research has shown that elevated expression of the protein GRP78/BiP in human lung cancers can be suppressed to inhibit KRAS mutation-mediated lung tumor progression. This study provides evidence that targeting GRP78 represents a novel therapeutic approach to suppress mutant KRAS-mediated lung tumorigenesis.
Article
Multidisciplinary Sciences
Shane Shahrestani, Tzu-Chieh Chou, Kuang-Ming Shang, Gabriel Zada, Zea Borok, Adupa P. Rao, Yu-Chong Tai
Summary: The article discusses the development of a non-contact wearable pulmonary sensor for pulmonary waveform analysis, volume quantification, and thoracic imaging. Statistical regression analysis confirms the predictive validity of the sensor, with data continuously digitally stored at a high sampling rate, facilitating rapid monitoring for high-risk individuals during the COVID-19 pandemic.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Laertis Ikonomou, Mattias Magnusson, Ruben Dries, Erica L. Herzog, Robert E. Hynds, Zea Borok, Jin-Ah Park, Steven Skolasinski, Janette K. Burgess, Leigh Turner, Sarah M. Mojarad, John E. Mahoney, Thomas Lynch, Mareike Lehmann, Victor J. Thannickal, Jamie L. Hook, Andrew E. Vaughan, Evan T. Hoffman, Daniel J. Weiss, Amy L. Ryan
Summary: The 9th biennial conference focused on the application of stem cells, cell therapies, and bioengineering in lung biology and diseases. The virtual event provided a platform for researchers to discuss advancements in the field, including technological innovations, stem cell signaling, airway engineering, viral infection response, and ethical considerations in cell-based treatments for lung diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Biology
Feng Gao, Changgong Li, Susan M. Smith, Neil Peinado, Golenaz Kohbodi, Evelyn Tran, Yong-Hwee Eddie Loh, Wei Li, Zea Borok, Parviz Minoo
Summary: Lung development is controlled by gene regulatory networks (GRN), and disruption of these networks can cause diseases like BPD. This study used a transgenic mouse model to construct an IGF1 signaling network associated with BPD, providing insights into the regulatory mechanisms. The findings have important implications for understanding and treating BPD, and further research on the full signaling network is needed.
Article
Respiratory System
Bethany B. Moore, Megan N. Ballinger, Natalie N. Bauer, Timothy S. Blackwell, Zea Borok, G. R. Scott Budinger, Blanca Camoretti-Mercado, Serpil C. Erzurum, Blanca E. Himes, Venkateshwar G. Keshamouni, Hrishikesh S. Kulkarni, Rama K. Mallampalli, Thomas J. Mariani, Fernando J. Martinez, Janet E. McCombs, Dawn C. Newcomb, Richard A. Johnston, Michael A. O'Reilly, Y. S. Prakash, Karen M. Ridge, Patricia J. Sime, Anne I. Sperling, Shelia Violette, David S. Wilkes, Melanie Konigshoff
Summary: The American Thoracic Society established an ad hoc committee to identify barriers and opportunities for non-clinically practicing basic and translational scientists to integrate into clinical units. Based on surveys of division chiefs and workshop participants, it was found that hiring Ph.D. scientists into clinical units often resulted in non-tenure track positions without the same support as basic science units. These barriers are primarily financial. The recommendation is for academic medical centers to consider strategies to integrate basic and translational scientists into clinical units in a meaningful way.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Genetics & Heredity
Crystal N. Marconett, Beiyun Zhou, Kimberly D. Siegmund, Zea Borok, Ite A. Laird-Offringa