Article
Neurosciences
Eliza Bliss-Moreau, Anthony C. Santistevan, Jeffrey Bennett, Gilda Moadab, David G. Amaral
Summary: The study investigates the causal role of ACC in affective responding to threat in primates. Results suggest that the primate ACC is necessary for maintaining appropriate affective responses towards potentially harmful and/or novel stimuli, and that ACC lesions can lead to a reduced reactivity towards these stimuli, with implications for mood disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Jose Francis-Oliveira, Owen Leitzel, Minae Niwa
Summary: This article discusses the nomenclature of the medial prefrontal cortex (mPFC) subdivisions, proposing a change in the naming of the rodent cingulate cortex to anterior cingulate cortex (aCg) and mid-cingulate cortex (mCg). Based on data, the authors show evidence of distinct cortico-cortical projections from aCg and mCg to the PrL, as well as a sex difference in the aCg with males having a higher proportion of layer V neurons projecting to the PrL.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Marcos Domic-Siede, Martin Irani, Joaquin Valdes, Marcela Perrone-Bertolotti, Tomas Ossandon
Summary: The study reveals the importance of cognitive planning in human goal-directed behavior, with different brain regions playing specific roles in the planning process. Activity in the prefrontal cortex is associated with increased time needed for plan elaboration, while activity in the frontopolar cortex is negatively correlated with execution time, indicating its role in efficiency and accuracy in plan execution. Theta activity in different brain regions reflects high cognitive demand and the successful generation of self-made plans.
Article
Chemistry, Multidisciplinary
Ting Fan, Peng-Fei Guan, Xiao-Fang Zhong, Meng-Ya Xiang, Ying-Qiu Peng, Ruo-Qiao Zhou, Jia-Min Gong, Yu-Qing Zheng, A-Qiang Dai, Jia-Ling Feng, Hong-Zhe Yu, Jian Li, Hua-Wei Li, Yun-Feng Wang
Summary: Compared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. This study found that tinnitus is closely associated with abnormal metabolism and function in the limbic system, but the specific molecular mechanism is unknown. The anterior cingulate cortex (ACC) was identified as a key brain region involved in the onset of tinnitus in mice, and there were changes in metabolism and phosphorylation patterns in the glutamatergic synaptic pathway. Additionally, the electroencephalogram of tinnitus patients showed increased functional connectivity between the ACC and the primary auditory cortex, which was correlated with the serum glutamate level.
Article
Neurosciences
Cameron D. Hassall, Laurence T. Hunt, Clay B. Holroyd
Summary: This study investigates the impact of average task value on reward-related anterior cingulate cortex (ACC) activity, revealing that ACC evaluates outcomes and cues in the context of the current task value.
Article
Multidisciplinary Sciences
Mo Chen, Fengyang Ma, Zhaoqi Zhang, Shuhua Li, Man Zhang, Qiming Yuan, Junjie Wu, Chunming Lu, Taomei Guo
Summary: This study used fMRI to investigate the impact of short-term language switching training on the neural network of cognitive control in bilingual individuals. The results showed changes in neural connections after language switching training, indicating reduced neural connectivity required for completing cognitive control tasks.
Article
Multidisciplinary Sciences
Fei Luo, Jun -yang Deng, Xuan Sun, Jian Zhen, Xiao-dan Luo
Summary: Early-life stress has long-term impacts on the structure and function of the anterior cingulate cortex (ACC) and raises the risk of adult neuropsychiatric disorders including social dysfunction. Maternal separation (MS) during the first three postnatal weeks in female mice leads to social impairment accompanied by hypo-activity in pyramidal neurons (PNs) of the ACC. Activation of ACC PNs improves MS-induced social impairment. The down-regulation of neuropeptide Hcrt, which encodes hypocretin (orexin), is observed in the ACC of MS females. Activation of ACC orexin terminals enhances the activity of ACC PNs and restores the diminished sociability in MS females through an orexin receptor 2 (OxR2)-dependent mechanism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Norma Verdolini, Marta Moreno-Ortega, Pilar Salgado-Pineda, Gemma Monte, Ana Martinez de Aragon, Monica Dompablo, Peter J. McKenna, Raymond Salvador, Tomas Palomo, Edith Pomarol-Clotet, Roberto Rodriguez-Jimenez
Summary: This study examined the brain activity of bipolar disorder patients during the Stroop task and found that there were no differences in activation between the patients and healthy subjects. However, the patients showed significant failure of de-activation in specific brain regions. These findings suggest that the regulatory component of cognitive control remains intact in bipolar disorder, but there may be dysfunction in the default mode network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Xiaona Fu, Mengting Qin, Xiaoming Liu, Lan Cheng, Lan Zhang, Xinli Zhang, Yu Lei, Qidong Zhou, Peng Sun, Liangjie Lin, Ying Su, Jing Wang
Summary: This study investigated the relationship between GABA levels, cortical thickness, and executive function in MCI patients. The results showed that MCI patients had lower GABA+/Cr levels in the ACC and PCC, while there were no differences in cortical thickness between the two groups. Therefore, GABA in the ACC and PCC could be a potential diagnostic marker for the decline in executive function in MCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Giovana Benassi-Cezar, Isabela Miranda Carmona, Daniela Baptista-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Summary: The study found that cohabitation with a conspecific suffering from chronic pain affects the anxiety levels of mice, with changes in neuronal activation observed in the anterior cingulate and insular cortices. Injecting a synaptic blocker in these brain areas can reverse the anxiety-inducing effect caused by cohabitation with a conspecific in chronic pain.
Article
Pharmacology & Pharmacy
Yong He, Yue Wang, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong, Yi Guo, Peng Xie
Summary: Neuroinflammation is closely linked to the onset of depression. Nr4a2 protein plays a role in dopaminergic neurons and can alleviate inflammation. However, its effects on neuroinflammation associated with depression are still unclear.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Yujiao Yang, Dong Chen, Jing Wang, Jie Wang, Zhaofen Yan, Qinqin Deng, Liping Zhang, Guoming Luan, Mengyang Wang, Tianfu Li
Summary: This study aimed to investigate the dynamic coupling between the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) during seizures. The results showed that the functional connectivity and excitability between these two brain regions significantly increased at seizure onset. By analyzing the connectivity and excitability, the seizure-onset zone (SOZ) in ACC and AIC can be identified.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.