Review
Physiology
Maria Cimini, Raj Kishore
Summary: New insights into the cellular and extra-cellular composition of scar tissue after myocardial infarction have identified a heterogeneous podoplanin-expressing cell population associated with fibrogenic and inflammatory responses during scar formation. Podoplanin, mainly expressed by cardiac lymphatic endothelial cells in adult mouse hearts, is unexpectedly acquired by different types of cells after MI, suggesting an activation of progenitor cells during post-ischemic myocardial wound repair. Inhibition of the interaction between podoplanin-expressing cells and podoplanin-binding cells using podoplanin-neutralizing antibodies showed reduced inflammation post-MI and improved heart function and scar composition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Yinhang Wang, Mengling Wang, Fengling Ning, Dadui Ren, Jie Tao, Weiyi Xie, Douglas C. Eaton, Gengru Jiang, Alton B. Farris, Hong Xin, Hui Cai, Xuemei Zhang
Summary: This study found that the decreased activity of BK channels is associated with increased fibrotic marker expression in kidney fibrosis. Activation of BK channels can inhibit the TGF-beta signaling pathway and degrade TGF-beta receptors, thereby exerting an anti-fibrotic effect. This research provides innovative insights for the development of new strategies to treat kidney fibrosis.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Amir H. Sharif, Mohammed Iqbal, Bahareh Manhoosh, Negin Gholampoor, Dan Ma, Mandeep Marwah, Lissette Sanchez-Aranguren
Summary: CNS-related conditions are a major cause of disability globally and are associated with inflammation and impaired oxidative response. Hydrogen sulphide (H2S) has a neuroprotective role and therapeutic approaches targeting its mechanisms have been explored. Defects in H2S metabolism have been identified in CNS-related disorders, but restoring H2S availability using H2S-donating compounds has shown promise in several models. However, more research is needed to understand their implications and improve delivery to CNS tissues.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Xuefeng Zhang, Cuiyun Liu, Changlong Hu
Summary: The study identified differences in the hydrogen bond controls for slow inactivation between mammalian Kv channels and Shaker channels, indicating the crucial role of the inter-subunit hydrogen bond formed by W366 and Y376 in regulating the K+ conductance in mammalian Kv2.1, Kv2.2, and Kv1.2 channels.
Article
Multidisciplinary Sciences
Chen Zhao, Roderick MacKinnon
Summary: K-ATP channels act as metabolic sensors translating ATP/ADP balance to membrane excitability. The structure of human pancreatic K-ATP reveals an open pore, coordinated structural changes within the ATP-binding site and channel gate in Kir, as well as conformational changes in SUR. The pancreatic hK(ATP) exhibits a unique PIP2-independent opening property.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Mohamed Khairy, Khaled G. Mahmoud
Summary: This research achieved the in-situ synthesis of nanostructured nickel sulphides through hydrothermal treatment of nickel foam, resulting in efficient water electrolyzers. The nickel sulphide nanoneedles exhibited excellent performance in the oxygen evolution reaction, while the sheet-like morphology showed low overpotential in the hydrogen evolution reaction. Integrating these materials with water electrolyzers offers a low-cost, sustainable, and scalable overall water splitting system.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Pharmacology & Pharmacy
Flavio Coceani
Summary: This article discusses the relationship between closure of the ductus arteriosus and blood oxygen tension. It proposes two different schemes and suggests that their combined activation is necessary for a complete contraction. This has significant implications for understanding the operation of the ductus and future translational research.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Valentin K. Gribkoff, Raymond J. Winquist
Summary: Several mutations to members of CNS potassium channel families are associated with rare forms of neonatal onset epilepsy or syndromes with epilepsy characteristics. These mutations significantly increase the probability of generalized seizure disorders and can result in more severe developmental syndromes. Efforts to target these syndromes through pharmacological or genetic modulation have been made.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biology
SeCheol Oh, Fabrizio Marinelli, Wenchang Zhou, Jooyeon Lee, Ho Jeong Choi, Min Kim, Jose D. Faraldo-Gomez, Richard K. Hite
Summary: Structures and simulations reveal the unique permeation mechanism of the human lysosomal K+ channel transmembrane protein 175 (TMEM175), which lacks the canonical K+ selectivity filter. Despite the absence of a selectivity filter, TMEM175 is selective for K+ over Na+ due to a narrow hydrophobic constriction and a favorable electrostatic field.
Article
Biochemistry & Molecular Biology
Rym ElFessi, Oussema Khamessi, Najet Srairi-Abid, Jean-Marc Sabatier, Jan Tytgat, Steve Peigneur, Riadh Kharrat
Summary: Bot33 is a new short polypeptide purified from the venom of Buthus occitanus tunetanus scorpion. It has potential therapeutic effects and displays a different mode of action on ion channels compared to other scorpion toxins, which is worth further exploration.
Article
Dermatology
Ling Li, Xudong Chen, Chang Liu, Ziying He, Qiyan Shen, Yue Zhu, Xin Wang, Shuanglin Cao, Shengju Yang
Summary: This study investigated the roles and mechanisms of hydrogen sulphide (H2S) on primary mice skin fibroblasts proliferation. The study found that H2S can inhibit the proliferation of skin fibroblasts and attenuate skin fibrosis by inhibiting necroptosis. These findings provide new insights into the prevention and treatment of skin fibrotic diseases.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Plant Sciences
A. K. Choudhary, S. Singh, N. Khatri, R. Gupta
Summary: Hydrogen sulphide, as a gaseous signalling molecule in plants, has potential roles in plant defence against invading pathogens through various mechanisms, such as modulating enzyme activity and inducing expression of defence-related genes.
Article
Chemistry, Physical
Murthy Muniyappa, Sagara N. Kalegowda, Manjunath Shetty, Jagadeesh Babu Sriramoju, Mahesh Shastri, Navakoteswara S. Rao, Debasis De, M. Shankar, Dinesh Rangappa
Summary: Metal chalcogenides are promising materials for photocatalytic hydrogen evolution. In this study, cocatalyst-free nickel sulfides with different nanostructures were synthesized and characterized. The synthesized nickel sulfides showed good photocatalytic activity for hydrogen generation under UV-Vis light irradiation.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Agronomy
Haitao Yu, Liuli Song, Jingjing Han, Xiaoyu Yu, Yuzhen Wu, Zhifang Yu
Summary: This study found that H2S treatment can delay the senescence process of postharvest pakchoi by regulating antioxidant system, endogenous H2S and NO metabolism. H2S increased the activities of antioxidant enzymes by up-regulating the expression of enzyme genes, reducing the accumulation of harmful substances. Furthermore, H2S increased the content of cysteine and nitrate in pakchoi by regulating the expression of related genes and enzyme activities, thus slowing down the senescence of pakchoi.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2024)
Article
Multidisciplinary Sciences
Francois Moisan, Sandra Oucherif, Priscilla Kaulanjan-Checkmodine, Sorilla Prey, Benoit Rousseau, Marc Bonneu, Stephane Claverol, Etienne Gontier, Sabrina Lacomme, Lea Dousset, Thierry Couffinhal, Jerome Toutain, Maya Loot, Muriel Cario-Andre, Marie-Laure Jullie, Christine Leaute-Labreze, Alain Taieb, Hamid Reza Rezvani
Summary: Propranolol, a nonselective beta-adrenergic receptor antagonist, is the first-line therapy for severe infantile hemangiomas (IH) and has shown potential adjuvant response in some malignant tumors. The mechanism for propranolol antitumor effect is largely unknown, but studies suggest that it may involve down-regulation of AQP1 water channel protein.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)