期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 17, 期 2, 页码 225-232出版社
WILEY
DOI: 10.1111/jcmm.12027
关键词
mechanoelectric feedback; mechanotransduction; mechanosensitive ion channels; arrhythmias; ischaemic; reperfusion injury; cardiogenesis; mechanomedicine
Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the FrankStarling law of the heart and mechanoelectric feedback. We then focused on molecules involved in mechanotransduction, particularly mechanosensitive ion channels. We have also discussed the involvement of mechanosensitivity in heart diseases, such as arrhythmias, hypertrophy and ischaemic heart disease. Finally, mechanobiology in cardiogenesis is described with regard to regenerative medicine.
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