期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 16, 期 6, 页码 1274-1285出版社
WILEY
DOI: 10.1111/j.1582-4934.2011.01412.x
关键词
oncostatin M; synovial fibroblasts; neutrophils; cytokines; chemokines; inflammation; murine dorsal air pouch
资金
- Canadian Institutes of Health Research (CIHR)
- Fonds de la Recherche en Sante du Quebec (FRSQ)
Oncostatin M (OSM) is a pleiotropic cytokine of the IL-6 family and displays both pro-inflammatory and anti-inflammatory activities. We studied the impact of OSM on the gene activation profile of human synovial cells, which play a central role in the progression of inflammatory responses in joints. In synovial cells stimulated with lipopolysaccharide and recombinant human granulocyte-macrophage colony-stimulating factor, recombinant human OSM and native OSM secreted by human granulocytes both reduced the gene expression and secretion of IL-1 beta and CXCL8, but increased that of IL-6 and CCL2. This impact on synovial cell activation was not obtained using IL-6 or leukaemia inhibitory factor. Signal transducer and activator of transcription-1 appeared to mediate the effects of OSM on stimulated human synovial fibroblasts. In the murine dorsal air pouch model of inflammation, OSM reduced the expression of the pro-inflammatory cytokines IL-1 beta and TNF-a in lining tissues, and their presence in the cavity. These results as a whole suggest an anti-inflammatory role for OSM, guiding inflammatory processes towards resolution.
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