Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.
Article
Microbiology
Sreekumar Othumpangat, William G. Lindsley, Donald H. Beezhold, Michael L. Kashon, Carmen N. Burrell, Samira Mubareka, John D. Noti
Summary: miRNAs play key roles in cell survival and virus replication, while exosomes are important for intercellular communication. Studies show that miRNAs are involved in regulating influenza virus replication. Analysis of circulating serum miRNAs and cytokines in influenza patients revealed differences in expression patterns, suggesting potential biomarkers for early infection detection.
Article
Immunology
Andres Alberro-Brage, Vitalii Kryvenko, Christina Malainou, Stefan Guenther, Rory E. Morty, Werner Seeger, Susanne Herold, Christos Samakovlis, Istvan Vadasz
Summary: Acute respiratory distress syndrome (ARDS) is a common complication of influenza virus (IV) infection, which leads to the accumulation and impairment of alveolar protein. It has been found that IV infection inhibits the clearance of alveolar protein, possibly through upregulation of a proteinase called MMP. In addition, inhibition of MMP proteinase may improve the clearance of alveolar protein and thus provide a potential therapeutic approach for ARDS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Adam D. Kenney, Stephanie L. Aron, Clara Gilbert, Naresh Kumar, Peng Chen, Adrian Eddy, Lizhi Zhang, Ashley Zani, Nahara Vargas-Maldonado, Samuel Speaks, Jeffrey Kawahara, Parker J. Denz, Lisa Dorn, Federica Accornero, Jianjie Ma, Hua Zhu, Murugesan V. S. Rajaram, Chuanxi Cai, Ryan A. Langlois, Jacob S. Yount
Summary: Cardiac dysfunction is a common complication of severe influenza virus infection, and it is unclear whether this occurs through direct infection of cardiac tissue or indirectly through systemic lung inflammation. In this study, a novel recombinant heart-attenuated influenza virus was generated, and it was found that robust virus replication in the heart is required for pathology, even when lung inflammation is severe.
Article
Cell Biology
Yanyan Bao, Yujing Shi, Lirun Zhou, Shuangrong Gao, Rongmei Yao, Shanshan Guo, Zihan Geng, Lei Bao, Ronghua Zhao, Xiaolan Cui
Summary: This study found that miR-205-5p can regulate the expression of viral NP protein by binding with the miRNA binding site of the NP gene, thereby inhibiting the replication of influenza A virus. Oseltamivir and Jinchai Antiviral Capsules could up-regulate the expression of miR-205-5p. These findings suggest that miR-205-5p may be a potential target for influenza A therapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Fangyuan Zhu, Zhenxiao Teng, Xuanchen Zhou, Runtong Xu, Xin Bing, Lei Shi, Na Guo, Min Wang, Chengcheng Liu, Ming Xia
Summary: This study found that H1N1 influenza virus infection causes abnormal arginine metabolism in nasal mucosal epithelial cells, leading to the recruitment and maturation of submucosal dendritic cells (DCs), and triggering respiratory mucosal immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wenjiao Wu, Chao Wang, Changliang Xia, Shuwen Liu, Qinghua Mei
Summary: The study reveals the regulatory effect of let-7 on influenza A infection, wherein let-7 can modulate interferon expression and inhibit viral replication. Additionally, let-7 may serve as a potential biomarker of influenza A infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Yaima Burgher Pulgaron, Chantale Provost, Marie-Jeanne Pesant, Carl A. Gagnon
Summary: This study investigates the pathogenesis of porcine circovirus type 2b (PCV2b) and swine influenza A virus (SwIV) co-infection in swine respiratory cells. The results show that the co-infection has different outcomes in different cell types, affecting viral replication and cytokine expression. RNA-sequencing reveals the modulation of gene expression and cellular pathways during PCV2b and SwIV H1N1 co-infection, providing new insights on the pathogenesis of porcine viral co-infections.
Article
Virology
Abhijeet A. Bakre, Les P. Jones, Jackelyn Murray, Z. Beau Reneer, Victoria A. Meliopoulos, Sean Cherry, Stacey Schultz-Cherry, Ralph A. Tripp
Summary: This study examined the innate antiviral response to swine influenza virus in primary and immortalized swine nasal and tracheal epithelial cells, showing strain- and host cell type-dependent differential expression of key interferons and interferon-stimulated genes.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Pinar Yazici ozkaya, Ese Eda Turanli, Hamdi Metin, Ayca Aydin Uysal, Candan cicek, Bulent Karapinar
Summary: This study aimed to identify the clinical features and mortality associated with severe influenza A and B virus infections in children admitted to the pediatric intensive care unit (PICU) between 2012 and 2019. The study found that although the proportion of influenza A cases admitted to the PICU was higher, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. Additionally, there was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengcheng Liu, Xin Bing, Wenwen Qi, Fangyuan Zhu, Chengzhilin Li, Xiaochen Gao, Miaoqing Zhao, Ming Xia
Summary: In this study, it was found that H1N1 virus can induce ferroptosis of hNECs through the NRF2-KEAP1-GCLC signaling pathway and glutaminolysis, leading to nasal mucosal epithelial inflammation. This discovery provides a potential therapeutic target for viral-induced nasal inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Virology
Raegan M. Skelton, Victor C. Huber
Summary: This article reviews the known information about the host-pathogen interactions that limit the disease caused by influenza D virus (IDV). It focuses on the early immune interactions between the virus and infected host cells in IDV pathogenesis. This work establishes a foundation for further research on IDV infection and immunity in mammalian hosts.
Article
Cell Biology
Sang-Sang Park, Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Hansol Im, Yvette Hale, Maryann P. Platt, Christina Croney, David E. Briles, Carlos J. Orihuela
Summary: The study demonstrates the adhesion function of PspA to dying host cells and its importance in pneumococcal pneumonia, particularly in the context of co-infection with IAV. The binding of PspA to GAPDH protein is mediated through its specific alpha-helical domain, and a specific interaction between PspA and dying cells is identified.
Article
Microbiology
Jian Lin, Yanan Cao, Jinjiao Zuo, Shuai Zhang, Qinghua Yu, Qian Yang, Abid Ullah Shaha, Mark M. W. Chong
Summary: This study found that the Non-structural protein 2 (NS2) of Influenza A viruses (IAV) inhibits the maturation and antigen-presenting ability of dendritic cells (DCs). NS2 impairs miRNA biogenesis pathway by binding to exportin 5 (Xpo5), and also interacts with interferon regulatory factor 3 to further inhibit the antigen-presenting ability of DCs.
VETERINARY MICROBIOLOGY
(2022)
Article
Plant Sciences
Qiuling Du, Wenbo Huang, Jin Zhao, Jun Zeng, Wenjie Zhang, Xiaodong Huang, Ruifeng Chen, Haiming Jiang, Yuqi Xie, Yutao Wang, Nanshan Zhong, Xinhua Wang, Zifeng Yang
Summary: The study demonstrated that Lianhuaqingwen capsule significantly reduced MRSA adhesion to PR8-infected lung epithelial cells, suppressed the up-regulation of bacterial receptors, and decreased the overexpression of inflammatory cytokines. In a severe pneumonia model, LHQW alleviated abnormal changes in lung index in dual-infected mice, but did not significantly improve survival rate or prolong survival time.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Business
Yangyan Shi, Xiaofei Zheng, V. G. Venkatesh, Eias A. Humdan, Sanjoy Kumar Paul
Summary: This study is a pioneering research on the relationships among digital technology, supply chain integration, and supply chain resilience. The findings of this study suggest that firms need to improve digital technology, supply chain integration, and supply chain resilience accordingly.
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING
(2023)
Article
Biochemical Research Methods
Noriaki Sato, Yoshinori Tamada, Gunagchuang Yu, Yasushi Okuno
Summary: In this study, the researchers developed an R package called CBNplot, which can infer Bayesian networks from gene expression data and visualize and compare enrichment analysis results. The package has the potential to facilitate the study of gene regulatory networks and knowledge discovery in gene expression datasets.
Article
Biochemistry & Molecular Biology
Lianlian Wu, Bowei Yan, Junshan Han, Ruijiang Li, Jian Xiao, Song He, Xiaochen Bo
Summary: TOXRIC is a comprehensive database that provides toxicological data, standardized attribute data, practical benchmarks, and informative visualization of molecular representations. It can greatly facilitate toxicological investigations, interpretation of toxicological mechanisms, compound/drug discovery, and the development of computational methods.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hexi Yang, Fumin Tai, Tiantian Wang, Xiaofei Zheng, Changhui Ge, Yide Qin, Hanjiang Fu
Summary: In this study, it was found that hydroxyl radical (center dot OH) generated from the intracellular Fenton reaction can induce significant cell death. The Fenton reaction between Fe2+ with H2O2 resulted in a shift in lipid peroxidation and cell cycle arrest. The center dot OH generated from the Fenton reaction triggered severe apoptosis but did not lead to DNA double-strand breakage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Acoustics
Xiaodan Wang, Qiang Teng, Guiting Fang, Haiyan Fang, Luyv Zhao, Xiaofei Zheng, Xing Zhong
Summary: The value of real-time dynamic ultrasound in diagnosing delaminated tears and evaluating their ultrasonic characteristics was evaluated in this study. A total of 143 consecutive patients who underwent arthroscopic rotator cuff repair were examined using real-time dynamic ultrasound of the shoulder. Delaminated tears were classified into three types and the sensitivity and specificity of real-time dynamic ultrasound in diagnosing these tears were calculated. Three important ultrasonic signs were identified for the diagnosis of delaminated rotator cuff tears.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Multidisciplinary Sciences
Zhuo-Xing Shi, Zhi-Chao Chen, Jia-Yong Zhong, Kun-Hua Hu, Ying-Feng Zheng, Ying Chen, Shang-Qian Xie, Xiao-Chen Bo, Feng Luo, Chong Tang, Chuan-Le Xiao, Yi-Zhi Liu
Summary: Long-read single-cell RNA isoform sequencing can reveal the complex landscape of alternative RNA splicing in individual cells, but it has a low read throughput. The authors developed circular consensus sequencing methods to achieve high-throughput and high-accuracy single-cell RNA isoform sequencing.
NATURE COMMUNICATIONS
(2023)
Article
Orthopedics
Shunjie Yang, Shurong Zhang, Ruixin Li, Chunxi Yang, Jiapeng Zheng, Cheng Wang, Jun Lu, Zhengzheng Zhang, Xiliang Shang, Hui Zhang, Weiming Wang, Weiping Li, Jingmin Huang, Yadong Zhang, Jianquan Wang, You Wang, Xiaofei Zheng, Gang Chen, Yinghui Hua, Shiyi Chen, Jian Li
Summary: The expert consensus on discoid lateral meniscus (DLM) was developed and approved by the Chinese Society of Sports Medicine using the Delphi method. It focused on various aspects such as definition, epidemiology, etiology, classification, clinical manifestations, diagnosis, treatment, prognosis, and rehabilitation of DLM. The preferred treatment method is to restore the normal shape, retain appropriate width and thickness, and ensure the stability of the remnant meniscus.
ORTHOPAEDIC SURGERY
(2023)
Article
Oncology
Chong Zhang, Xiang-Yu Wang, Jie-Liang Zuo, Xue-Fu Wang, Xiao-Wen Feng, Bo Zhang, Yi-Tong Li, Chen-He Yi, Peng Zhang, Xiao-Chen Ma, Zhen-Mei Chen, Yue Ma, Jia-Hao Han, Bao-Rui Tao, Rui Zhang, Tian-Qi Wang, Li Tong, Wang Gu, Si-Yu Wang, Xiao-Fei Zheng, Wen-Kang Yuan, Zi-Jie Kan, Jie Fan, Xiang-Yang Hu, Jun Li, Chao Zhang, Jin-Hong Chen
Summary: Tertiary lymphoid structures (TLSs) in colorectal cancer liver metastases (CRCLM) are found to be associated with prognosis. The study analyzed data from 603 CRCLM patients and found that higher intratumor TLSs score is correlated with better prognosis, while higher peritumor TLSs score is correlated with poorer survival. Additionally, the study also found a correlation between immune cell composition within TLSs and TLSs score.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Wenli Tang, Huimin Zheng, Shuangbin Xu, Pan Li, Li Zhan, Xiao Luo, Zehan Dai, Qianwen Wang, Guangchuang Yu
Summary: The gut metabolome plays a crucial role in the relationship between gut microbiota and the host, and has great potential for diagnosis and therapy. This study developed a computational framework called Microbe-Metabolite INteractions-based metabolic profiles Predictor (MMINP) to predict the metabolic profiles associated with the gut microbiota. The predictive value of MMINP was demonstrated and the factors influencing the prediction performance of data-driven methods were identified.
Article
Multidisciplinary Sciences
Xiaofei Zheng, Li Tong, Chong Zhang, Chaoyang Zhang, Chao Zhang, Bangbei Wan
Summary: This study investigated the causal relationship between 19 modifiable risk factors and major depressive disorder (MDD). SNPs associated with these risk factors were screened using GWAS, and summary-level data from the UK Biobank were analyzed. The findings revealed that smoking, education level, sleep quality, personal feelings, and various factors related to lifestyle were all causally associated with the risk of MDD.
Article
Multidisciplinary Sciences
Xiaofei Zheng, Xin Zhou, Li Tong, Wang Gu, Siyu Wang, Wenkang Yuang, Chong Zhang, Chaoyang Zhang, Chao Zhang, Bangbei Wan
Summary: This study systematically investigated the causal relationship between gastroesophageal reflux disease (GERD) and major depression (MD) and found a bidirectional causal association between the two.
Article
Biology
Lu Han, Bin Song, Peilin Zhang, Zhi Zhong, Yongxiang Zhang, Xiaochen Bo, Hongyang Wang, Yong Zhang, Xiuliang Cui, Wenxia Zhou
Summary: Cellular transitions play a crucial role in translational medicine research. This study introduces a computational framework, PC3T, which enriches small molecules that induce desired cellular transitions. The framework was able to predict the reprogramming of fibroblasts into hepatic progenitor-like cells and provide a valuable resource for cell state transition research.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Longteng Wang, Yang Zheng, Yu Sun, Shulin Mao, Hao Li, Xiaochen Bo, Cheng Li, Hebing Chen
Summary: Early embryonic development relies on proper cell-cell communication, and this study developed a computational framework called TimeTalk to decipher the secrets of early embryo development. By analyzing time-course mouse scRNA-seq data, this study found that ligand-receptor pairs play a crucial role in cell fate decisions and morphogenesis during early embryo development.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemical Research Methods
Lianlian Wu, Jie Gao, Yixin Zhang, Binsheng Sui, Yuqi Wen, Qingqiang Wu, Kunhong Liu, Song He, Xiaochen Bo
Summary: Combination therapy is a promising approach for treating complex diseases, but the large search space of drug combinations poses challenges for experimental screening. In this study, we propose an improved deep forest-based method called ForSyn to predict synergistic drug combinations in different cancer cell lines. ForSyn effectively handles imbalanced and high-dimensional data in medium-/small-scale datasets, outperforming 12 state-of-the-art methods in terms of predictive performance. We also validate the predictive value of ForSyn with cell-based experiments and identify key genes that may play important roles in cancer.
CELL REPORTS METHODS
(2023)
Article
Biochemical Research Methods
Xiaojing Wu, Mingfei Han, Xinyu Song, Song He, Xiaochen Bo, Yunping Zhu
Summary: COMMO is the first web server capable of identifying and analyzing consensus gene functionally related gene modules from different module detection methods. It offers a variety of module detection methods, data sources, and analysis functions, providing a user-friendly solution for precision medicine research.