Article
Materials Science, Biomaterials
Amit Khurana, Mohd Aslam Saifi, Chandraiah Godugu
Summary: Chronic pancreatitis (CP) is an inflammatory and irreversible disorder of the pancreas that can lead to organ atrophy and an increased risk of pancreatic cancer. Nanoparticles of cerium oxide (nanoceria, NC) have shown potential as a pharmacological therapy for CP. In animal models of CP, nanoceria improved biochemical parameters and reduced inflammation by inhibiting cytokines and chemokines. It also attenuated fibrogenesis by inhibiting TGF-beta signaling, endoplasmic reticulum stress, and epithelial-to-mesenchymal transition. These findings demonstrate the anti-CP potential of nanoceria as a novel redox regenerative therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Physiology
Yasunobu Yamashita, Reiko Ashida, Masayuki Kitano
Summary: Chronic pancreatitis is a condition characterized by long-standing inflammation of the pancreas, leading to irreversible and progressive fibrosis. Various imaging modalities, including magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), computed tomography (CT), and endoscopic ultrasonography (EUS), are used to diagnose and assess chronic pancreatitis. Among these modalities, EUS is considered the most reliable and efficient diagnostic tool for pancreatic diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meifang Zheng, Runping Gao
Summary: This article reviews the mechanisms and potential therapeutic effects of vitamin D and its analogues in the treatment of pancreatic fibrosis, as well as the relationship between vitamin D deficiency and the risk of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Guenter Kloeppel, Giuseppe Zamboni
Summary: This passage presents the progress made in the diagnosis and recognition of pancreatitis, necroinflammatory and fibroinflammatory processes. It focuses on the pathology and pathogenesis of alcohol-associated pancreatitis, including paraduodenal pancreatitis. The article also discusses the histopathological characteristics and imaging findings associated with these conditions.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Santhi Swaroop Vege, Suresh T. Chari
Summary: Chronic pancreatitis is often associated with alcohol use, smoking, or genetic risk factors. Common symptoms include recurrent abdominal pain or pancreatitis, and characteristic imaging findings include pancreatic stones, dilated ducts, and atrophy. Complications include pseudocysts, biliary strictures, exocrine and endocrine pancreatic insufficiency, bone loss, and pancreatic cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Juliane Glaubitz, Saeedeh Asgarbeik, Rabea Lange, Hala Mazloum, Hager Elsheikh, Frank Ulrich Weiss, Matthias Sendler
Summary: Acute pancreatitis is a common inflammatory disease of the gastrointestinal tract and is increasingly diagnosed in hospitalized patients. It often progresses to chronic pancreatitis over time, with immune response playing a significant role in determining the severity and course of the disease. The mortality rate of acute pancreatitis is high, caused by excessive inflammation or inhibition of bacterial defense mechanisms leading to severe necrotizing pancreatitis. Targeting the immune response is the most promising therapeutic strategy, but the complexity of the immune response and the risk of chronic disease development limit treatment interventions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiang-Peng Zeng, Jing-Hui Zeng, Xia Lin, Yan-Hong Ni, Chuan-Shen Jiang, Da-Zhou Li, Xiao-Jian He, Rong Wang, Wen Wang
Summary: The study demonstrated that puerarin effectively ameliorated pancreatic atrophy, inflammation and fibrosis in a murine model of chronic pancreatitis. Additionally, puerarin displayed significant inhibition on the proliferation, migration and activation of pancreatic stellate cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Biomaterials
Amit Khurana, Mohd Aslam Saifi, Chandraiah Godugu
Summary: Chronic pancreatitis (CP) is an inflammatory disorder of the pancreas with no approved therapy. In this study, we investigated the potential of cerium oxide nanoparticles (nanoceria, NC) in treating CP animal models. Nanoceria showed improvement in biochemical parameters and reduced inflammation by inhibiting macrophage signaling and cytokine production. Furthermore, NC attenuated fibrosis by inhibiting TGF-beta signaling, endoplasmic reticulum stress, and epithelial-to-mesenchymal transition. Our findings demonstrate the anti-CP potential of nanoceria in two CP models.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Amit Khurana, Mohd Aslam Saifi, Chandraiah Godugu
Summary: In this study, the efficacy of yttrium oxide nanoparticles (NY) as an antioxidant and anti-inflammatory agent in chronic pancreatitis (CP) was tested. The results showed that NY treatment reduced oxidative-nitrosative stress, suppressed inflammatory cytokines, and inhibited fibrosis signaling. Furthermore, NY treatment also suppressed TGF-beta signaling and epithelial-mesenchymal transition (EMT) in CP.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mohamed Saleh, Kartikeya Sharma, Ranjeet Kalsi, Joseph Fusco, Anuradha Sehrawat, Jami L. Saloman, Ping Guo, Ting Zhang, Nada Mohamed, Yan Wang, Krishna Prasadan, George K. Gittes
Summary: This study developed a new potential therapy for patients with chronic pancreatitis by injecting acetic acid in experimental animals, effectively reducing chronic inflammation and pain, improving glucose tolerance and insulin secretion. It shows the potential of treating chronic pancreatitis in a nonsurgical way.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Hyuncheol Oh, Youn-Chul Kim, Yeun-Ja Mun, Gi-Sang Bae, Sung-Joo Park
Summary: Arecae pericarpium (ARP) exhibits anti-fibrotic effects in cerulein-induced chronic pancreatitis (CP), improving glandular atrophy, inflammation, and repressing collagen deposition in the pancreas.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yang Wu, Chun Zhang, Mei Guo, Weikang Hu, Yangling Qiu, Mengran Li, Dong Xu, Pengfei Wu, Jing Sun, Run Shi, Zili Zhang, Kuirong Jiang
Summary: Chronic pancreatitis (CP) is a precancerous illness associated with pancreatic ductal adenocarcinoma (PDAC), but the mechanism of evolution is uncertain. CP is characterized by severe fibrosis caused by the activation of pancreatic stellate cells (PSCs). The current clinical therapeutic protocol lacks specific medicines for preventing and suppressing inflammation and fibrosis in CP. Research on targeting PSCs could lead to the development of novel therapies for pancreatic fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Man Chang, Wenjuan Chen, Ruting Xia, Yangyue Peng, Pandi Niu, Hui Fan
Summary: This article reviews the interaction between chronic pancreatitis and pancreatic fibrosis, summarizes the activation mechanisms of pancreatic stellate cells, and investigates potential therapeutic strategies targeting these cells, including anti-fibrosis therapy, antioxidant therapy, and gene therapy.
Review
Cell Biology
Dingxi Zhou, Mariana Borsa, Anna Katharina Simon
Summary: The ageing population poses challenges to health and social care, with deteriorating immune systems contributing to chronic age-related diseases. More knowledge is needed on the aged immune system for developing COVID-19 treatments, with cellular senescence playing a key role in immune ageing. Deepening the understanding of immune cell senescence may lead to potential druggable pathways for reversing immune ageing.
Article
Oncology
N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Kohn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker
Summary: The TWEAK/Fn14 signalling pathway plays a crucial role in tissue injury and regeneration, and its involvement in pancreatic injury and cancer is not well understood. This study demonstrates that TWEAK/Fn14 signalling is important in the establishment and progression of chronic pancreatitis, increasing the risk of pancreatic cancer. The findings suggest the TWEAK/Fn14 pathway as a potential therapeutic target.
Article
Neurosciences
Luisa Roch, Michael Hecker, Joerg Friess, Ines Charlotte Angerer, Dirk Koczan, Brit Fitzner, Ina Schroeder, Kristin Flechtner, Hans-Juergen Thiesen, Stefanie Meister, Alexander Winkelmann, Uwe Klaus Zettl
MOLECULAR NEUROBIOLOGY
(2017)
Article
Endocrinology & Metabolism
Anja Osterberg, Robby Engelmann, Brigitte Mueller-Hilke
JOURNAL OF BONE AND MINERAL METABOLISM
(2018)
Article
Immunology
R. Engelmann, A. Biemelt, A. Johl, D. Kuthning, B. Mueller-Hilke
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Rheumatology
Robby Engelmann, Sven Nekarda, Daniela Kuthning, Christian Kneitz, Brigitte Mueller-Hilke
CLINICAL RHEUMATOLOGY
(2018)
Article
Neurosciences
Ines C. Angerer, Michael Hecker, Dirk Koczan, Luisa Roch, Joerg Friess, Annelen Ruege, Brit Fitzner, Nina Boxberger, Ina Schroeder, Kristin Flechtner, Hans-Juergen Thiesen, Alexander Winkelmann, Stefanie Meister, Uwe K. Zettl
CNS NEUROSCIENCE & THERAPEUTICS
(2018)
Article
Gastroenterology & Hepatology
Franz-Tassilo Mueller-Graff, Brit Fitzner, Robert Jaster, Brigitte Vollmar, Dietmar Zechner
WORLD JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Multidisciplinary Sciences
Joerg Friess, Michael Hecker, Luisa Roch, Dirk Koczan, Brit Fitzner, Ines Charlotte Angerer, Ina Schroeder, Kristin Flechtner, Hans-Juergen Thiesen, Alexander Winkelmann, Uwe Klaus Zettl
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Dirk Koczan, Brit Fitzner, Uwe Klaus Zettl, Michael Hecker
Article
Genetics & Heredity
Michael Hecker, Nina Boxberger, Nicole Illner, Brit Fitzner, Ina Schroeder, Alexander Winkelmann, Ales Dudesek, Stefanie Meister, Dirk Koczan, Peter Lorenz, Hans-Juergen Thiesen, Uwe Klaus Zettl
Review
Immunology
Michael Hecker, Annelen Ruege, Elena Putscher, Nina Boxberger, Paulus Stefan Rommer, Brit Fitzner, Uwe Klaus Zettl
AUTOIMMUNITY REVIEWS
(2019)
Review
Immunology
Florian Deisenhammer, Henrik Zetterberg, Brit Fitzner, Uwe K. Zettl
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Hematology
Sebastian Boettcher, Robby Engelmann, Georgiana Grigore, Paula Fernandez, Joana Caetano, Juan Flores-Montero, Vincent H. J. van der Velden, Michaela Novakova, Jan Philippe, Matthias Ritgen, Leire Burgos, Quentin Lecrevisse, Sandra Lange, Tomas Kalina, Javier Verde Velasco, Rafael Fluxa Rodriguez, Jacques J. M. van Dongen, Carlos E. Pedreira, Alberto Orfao
Summary: Reproducible expert-independent flow cytometric criteria for differential diagnoses between mature B-cell neoplasms were developed and validated using algorithm-driven classification. The diagnostic algorithm showed high accuracy and predictive values for various diseases, contributing to increased reproducibility in future diagnostics for mature B-cell neoplasms.
Article
Oncology
Sabrina Jotschke, Susann Schulze, Nadja Jaekel, Beatrice Ludwig-Kraus, Robby Engelmann, Frank Bernhard Kraus, Christina Zahn, Nicole Nedlitz, Gabriele Prange-Krex, Johannes Mohm, Bettina Peuser, Maik Schwarz, Claudia Spohn, Timo Behlendorf, Mascha Binder, Christian Junghanss, Sebastian Boettcher, Haifa Kathrin Al-Ali
Summary: In this study, the kinetics of SARS-CoV-2 spike-protein antibodies and the cellular immune responses after vaccination were investigated in patients with hematologic neoplasms. The results showed that most patients with hematologic malignancies had vaccine-elicited immunogenicity, with a significant increase in seroconversion at day 120. The cellular responses in lymphoid patients were comparable to those in the control group. These findings are important for determining the immune responses in patients with hematologic malignancies and for informing public health policies on booster doses.
Article
Hematology
Robby Engelmann, Nadja Jaekel, Sabrina Jotschke, Beatrice Ludwig-Kraus, Frank Bernhard Kraus, Neha Kumari, Susann Schulze, Michael Hecker, Christina Zahn, Haifa Kathrin Al-Ali, Christian Junghanss, Sebastian Boettcher
Summary: In this study, the mechanisms of severe acute respiratory syndrome coronavirus 2 vaccination success in patients with hematological neoplasia were elucidated. The study found that patients with lymphoid malignancies had insufficient IgG response but healthy CD4+ T-cell function, while patients with myeloid neoplasia had fewer spike-specific CD4+ responses but normal seroconversion rate. It was also observed that vector-based vaccines were more effective in inducing CD4+ and CD8+ T-cell responses. The study provides valuable insights for tailored vaccination strategies in patients with hematological neoplasia.
Article
Medicine, Research & Experimental
Robby Engelmann, Brigitte Mueller-Hilke
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
(2017)