Article
Pharmacology & Pharmacy
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang
Summary: Liver cancer is a common malignancy with drug resistance being a major challenge in treatment. This study demonstrates that Dihydrotanshinone (DHTS) can inhibit the growth of hepatocellular carcinoma by suppressing the JAK2/STAT3 signaling pathway, suggesting its potential as a chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan
Summary: The study revealed that panaxadiol significantly inhibited proliferation and induced apoptosis in human pancreatic cancer cells, as well as suppressed the migration of pancreatic cancer cells, suggesting its potential as an anti-tumor agent for pancreatic cancer treatment.
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Chemistry, Multidisciplinary
Yool Lee, Chaeun Oh, Jin Kim, Myong-Suk Park, Woo Kyun Bae, Kyung Hyun Yoo, Seungwoo Hong
Summary: The activation of dioxygen plays a crucial role in aerobic life, with metal ions' redox versatility being essential for processes involving reactive oxygen species. Synthetic metal complexes have shown potential in activating dioxygen and generating ROS, with implications for cancer treatment and the development of potent antitumor agents.
Article
Integrative & Complementary Medicine
Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao
Summary: Toosendanin (TSN) extracted from Melia toosendan Sieb et Zucc has been demonstrated to possess antitumor activities on ovarian cancer cells, inhibiting cell proliferation, inducing apoptosis, reducing mitochondrial membrane potential, and suppressing invasion and migration. TSN's effects are associated with modulation of expression levels of key proteins related to the caspase-dependent mitochondrial apoptotic pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Food Science & Technology
Peiying Shi, Tianyu Du, Fei Meng, Shihui Xie, Shuo Han, Jiali Yang, Yi Zhang, Yang Sun, Jietao Gong, Hong Yao
Summary: This study aims to reveal the effect and mechanism of ethanol extract of propolis (EEP) against diabetic cardiomyopathy (DCM). The results showed that EEP improved blood glucose regulation ability, cardiac function, and reduced myocardial oxidative stress in streptozotocin-induced diabetic rats. Additionally, EEP increased cell survival rate, decreased lactate dehydrogenase and malondialdehyde levels, and increased antioxidant enzyme levels in high glucose-injured H9c2 cells. EEP also affected the expression of genes and signaling pathways related to DCM.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, Research & Experimental
Haixiang Ding, Xiuchong Yu, Zhilong Yan
Summary: This study found that Ailanthone can suppress the activity of colon cancer cells HCT116 and SW620 by inhibiting cell proliferation and migration, inducing apoptosis and cell cycle arrest. These effects are mediated through the JAK/STAT3 signaling pathway and caspase and Bcl-2 family proteins.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zhu
Summary: Daphnetin pretreatment significantly alleviated SAP-induced pancreatic and lung tissue damage by inhibiting the activation of the JAK2-STAT3 signaling pathway, reducing inflammatory cytokine concentrations, decreasing cell apoptosis, and inhibiting white blood cell infiltration.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Pawan Kumar Raut, Hui Seong Lee, Sang Hoon Joo, Kyung-Soo Chun
Summary: Melanoma is a highly aggressive and treatment-resistant cancer, and a new study found that TQ can induce apoptosis in melanoma cells by hindering the Jak2/STAT3 signaling pathway through ROS generation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Dong Lin, Ruijie Qin, Lixin Guo
Summary: DR is a common complication of diabetes, with high TSH levels being associated with an increased prevalence; TSH may regulate glucose-induced PCs loss through mitochondrial apoptosis involving TSHR.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Xueli Tong, Chunqin Lao, Di Li, Jingmian Chen, Weijie Xu, Lu Li, Huiling Ye, Xiaofeng Guo, Jiejing Li
Summary: This study demonstrates that the purified polysaccharide ABPA1 from AVBEC can induce apoptosis in colorectal cancer cells by regulating the Bax and cytochrome-c mediated mitochondrial pathway. In vivo experiments show that ABPA1 significantly suppresses tumor growth in an orthotopic colon cancer model and has distinct impacts on the mitochondrial metabolism of colorectal cancer cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Neurosciences
Shining Xiao, Yu Zhang, Zihao Liu, Anan Li, Weilai Tong, Xu Xiong, Jiangbo Nie, Nanshan Zhong, Guoqing Zhu, Jiaming Liu, Zhili Liu
Summary: This study found that Alpinetin can improve the recovery of motor function after spinal cord injury by inhibiting microglia-mediated neuroinflammation and neuronal apoptosis. Additionally, Alpinetin can reverse the production of reactive oxygen species and decrease of mitochondrial membrane potential in activated microglia-mediated neuroinflammation. In vivo experiments further demonstrated that Alpinetin significantly inhibits the inflammatory response and neuronal apoptosis, promotes axonal regeneration, and improves motor function recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Fufeng Gao, Jinlong Chen, Tingting Zhang, Naifu Liu
Summary: LPCAT1 is over-expressed in cervical cancer tissues and is closely associated with poor prognosis. Silencing of LPCAT1 inhibits proliferation, migration, and invasion of cervical cancer cells and induces apoptosis. LPCAT1 regulates cervical cancer progression through the IL-6/STAT3 signaling pathway. LPCAT1 may serve as a potential prognostic biomarker and therapeutic target for cervical cancer.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Dongjun Jiang, Jiaqi Xu, Sitong Liu, Moussa Nasser, Wei Wei, Tianjiao Mao, Xintong Liu, Xiaopan Zou, Jiang Li, Xiaomeng Li
Summary: Rosmanol demonstrates anti-cancer potential by inhibiting the proliferation of breast cancer cells and promoting apoptosis, particularly through modulating apoptotic pathways and the generation of ROS.
Article
Cell Biology
Hui-Hui Sun, Xin-Min Feng, Jing-Cheng Wang, Jun Cai
Summary: Allicin may suppress the activity of vascular endothelial cells to prevent epidural hypertrophic scars, possibly through regulating the JAK2/STAT3 pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)