Editorial Material
Oncology
Song Chen, Andrew D. Luster
Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.
Article
Biochemistry & Molecular Biology
Andrea Ameruoso, Maria Claudia Villegas Kcam, Katherine Piper Cohen, James Chappell
Summary: The rise of antibiotic-resistant bacteria is a major threat to global health, necessitating the discovery of new antibiotics. Natural products derived from Streptomyces offer a diverse pool of chemical molecules for potential antibiotic discovery. However, the poor expression of biosynthetic gene clusters (BGCs) responsible for natural product synthesis under laboratory conditions poses a challenge for isolating and screening novel chemicals. This study presents a novel approach using synthetic gene regulators based on CRISPR-Cas to activate silent BGCs by rewiring endogenous regulation. These tools enable programmable activation of silent BGCs and advance the synthetic regulatory toolbox for Streptomyces, facilitating the discovery of new chemical compounds.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Clinical Neurology
Bin Li, Leilei Chang, Qian-Xing Zhuang
Summary: The central histaminergic system plays an important role in regulating anxiety. Histaminergic neurons in the hypothalamus directly project to the bed nucleus of the stria terminalis (BNST), a brain region involved in anxiety and stress. The presence of histamine receptors in the BNST suggests their involvement in anxiety modulation. Blocking histamine receptors in the BNST ameliorated anxiety symptoms, suggesting a potential therapeutic strategy for anxiety disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemical Research Methods
Raquel Pagano-Marquez, Jose Cordoba-Caballero, Beatriz Martinez-Poveda, Ana R. Quesada, Elena Rojano, Pedro Seoane, Juan A. G. Ranea, Miguel Angel Medina
Summary: This study investigates the genes associated with angiogenesis and their interactions using information from rare diseases. By analyzing pathological phenotypes, the study identifies 18 clusters of angiogenesis-related diseases, with 16 of them having traceable gene connections in an interaction network. A total of 130 different genes are associated with these disease clusters, and six of them are confirmed to be involved in angiogenesis.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Thibaux Van der Stede, Laura Blancquaert, Flore Stassen, Inge Everaert, Ruud Van Thienen, Chris Vervaet, Lasse Gliemann, Ylva Hellsten, Wim Derave
Summary: Chronic blockade of histamine H-1/H-2 receptors impairs microvascular and mitochondrial adaptations to interval training in humans, leading to blunted functional adaptations in exercise capacity, glycemic control, and vascular function. This suggests that histamine H-1/H-2 receptors play a crucial role in the integrative exercise training response in humans, potentially affecting post-exercise muscle perfusion regulation.
Article
Immunology
Lucia Cremades-Jimeno, Maria Angeles de Pedro, Maria Lopez-Ramos, Joaquin Sastre, Pablo Minguez, Ignacio Mahillo Fernandez, Selene Baos, Blanca Cardaba
Summary: This study prioritized biomarkers based on their functionality associated with each respiratory disease and specific molecular motifs, improving the definition and usefulness of new molecular biomarkers. The research analyzed biomarker candidates for asthma and allergies to establish comprehensive disease models, emphasizing the importance of specificity and mechanistic implications for personalized diagnostics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemical Research Methods
Bernardina Scafuri, Anna Verdino, Nancy D'Arminio, Anna Marabotti
Summary: Pharmacological chaperones are compounds that can bind and stabilize proteins, preventing denaturation and degradation. Some of these compounds have been approved or are being investigated for the treatment of rare genetic metabolic disorders. Computational methods can assist in the search for these compounds and have been successfully applied in the discovery of promising molecules in this category.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Immunology
Karim Dib, Amal El Banna, Clara Radulescu, Guillermo Lopez Campos, Gerard Sheehan, Kevin Kavanagh
Summary: Histamine has different effects on neutrophil capture of bacteria and bacterial intracellular killing, mediated by H4R and H2R pathways respectively. Additionally, histamine can interfere with neutrophil phagocytosis by maintaining histamine levels.
JOURNAL OF INNATE IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Silvia Vavrova, Eva Struharnanska, Jan Turna, Stanislav Stuchlik
Summary: Metalloid tellurium compounds have toxic effects on both bacteria and humans, and increasing environmental pollution with tellurium may be linked to autoimmune, neurodegenerative, and oncological diseases. Resistance gene clusters to tellurium compounds have been identified in various bacterial species, exhibiting genetic and functional diversity. In addition to specific resistance mechanisms, tellurium and its toxic compounds interact with molecular systems for general detoxification and mitigation of oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron, Natalie Jane Michael
Summary: Histamine, a neuromodulator in the brain, contributes to the regulation of various physiological processes, including energy balance, through histaminergic signaling in the hypothalamus. Two histamine receptors, H1R and H3R, play important roles in key hypothalamic nuclei involved in energy homeostasis. Activation of H1R suppresses food intake, while activation of H3R stimulates appetite. The central histaminergic system is implicated in weight gain induced by atypical antipsychotics and has potential as a therapeutic target for obesity treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Anastasia Sudarikova, Mikhail Fomin, Regina F. Sultanova, Ying Zhao, Samantha Perez, Mark Domondon, Margarita Shamatova, Daria Lysikova, Denisha R. Spires, Daria Ilatovskaya
Summary: This study investigates the role of histamine-related pathways in the kidney, specifically in the collecting duct cells. The findings demonstrate the expression of histamine receptors and enzymes responsible for histamine metabolism and synthesis in these cells, as well as the effects of histamine on intracellular calcium and cAMP levels. Additionally, histamine inhibits the activity of epithelial sodium channels and decreases the expression of alpha ENaC. These results suggest potential implications of histamine in inflammation-related renal conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Jungsook Cho
Summary: Histamine and its receptors play important roles in cancer biology, promoting cancer development, growth, and metastasis through interactions with different HRs, and regulating immune cell infiltration with immunomodulatory function. Various HR ligands affect tumor progression in different cancer types, and HR subtype expression levels may serve as prognostic biomarkers in multiple cancers.
Article
Biochemistry & Molecular Biology
Huan Yang, Sam J. George, Dane A. Thompson, Harold A. Silverman, Tea Tsaava, Aisling Tynan, Valentin A. Pavlov, Eric H. Chang, Ulf Andersson, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Summary: Recent studies have shown that famotidine has anti-inflammatory effects and can attenuate the clinical course of COVID-19 by preventing cytokine storm. The mechanism of action involves activation of the inflammatory reflex, which inhibits inflammation and is mediated by alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR).
MOLECULAR MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Luke M. M. Evans, Pamela N. Romero N. Villela
Summary: An analysis of rare genetic variants shows their impact on human traits is mediated through similar biological pathways as common variants, enhancing our understanding of their influence on complex traits.
Editorial Material
Multidisciplinary Sciences
Scott Banta
Summary: A protein with a stronger binding affinity to lighter rare-earth metals than heavier ones has been discovered, despite their chemical similarities.
Article
Biophysics
Almudena Pino-Angeles, Themis Lazaridis
BIOPHYSICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Anibal Bueno, Rocio Rodriguez-Lopez, Armando Reyes-Palomares, Elena Rojano, Manuel Corpas, Julian Nevado, Pablo Lapunzina, Francisca Sanchez-Jimenez, Juan A. G. Ranea
EUROPEAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Hematology
Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallee, Sebastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Mueller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries, Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier, Josee Hebert, Guy Sauvageau, Judith B. Zaugg, Frederic Barabe, Caroline Pabst
Review
Biochemistry & Molecular Biology
Francisca Sanchez-Jimenez, Miguel Angel Medina, Lorena Villalobos-Rueda, Jose Luis Urdiales
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Cell Biology
Ivan Berest, Christian Arnold, Armando Reyes-Palomares, Giovanni Palla, Kasper Dindler Rasmussen, Holly Giles, Peter-Martin Bruch, Wolfgang Huber, Sascha Dietrich, Kristian Helin, Judith B. Zaugg
Article
Multidisciplinary Sciences
Armando Reyes-Palomares, Mingxia Gu, Fabian Grubert, Ivan Berest, Silin Sa, Maya Kasowski, Christian Arnold, Mao Shuai, Rohith Srivas, Simon Miao, Dan Li, Michael P. Snyder, Marlene Rabinovitch, Judith B. Zaugg
NATURE COMMUNICATIONS
(2020)
Review
Biochemistry & Molecular Biology
Aurelio A. Moya-Garcia, Almudena Pino-Angeles, Francisca Sanchez-Jimenez, Jose Luis Urdiales, Miguel Angel Medina
Summary: Histamine is a highly pleiotropic biogenic amine involved in various physiological processes, with complex effects mediated by different receptors. Its metabolism forms a complex network connecting important metabolic processes for homeostasis. Current research focuses on the relationship between the histamine system and other metabolic modules, aiming to fill information gaps and explore new perspectives.
Article
Immunology
Carolina R. Sanz, Guadalupe Miro, Natalia Sevane, Armando Reyes-Palomares, Susana Dunner
Summary: In this study, the host immune response during Leishmania infantum infection was evaluated through transcriptome sequencing in dogs. Differential gene expression and co-expression network analysis revealed significant differences in gene expression between control and sick dogs, and key co-expression modules were associated with immune response regulation. Sick dogs showed altered expression of immune cell cytokines, T cell and NK cell exhaustion markers, and disrupted functionality of B cells, monocytes, and macrophages. Long non-coding RNAs and chromatin organization may also contribute to the modulation of host immune response during L. infantum infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Tianyi Ding, Dmitry S. Karlov, Almudena Pino-Angeles, Irina G. Tikhonova
Summary: In this study, allosteric modulators at the receptor-lipid interface were investigated using molecular dynamics simulations and quantum chemical calculations. The results showed that weak polar interactions and long-range electrostatics contribute to the stability of allosteric modulators at this interface. The presence of allosteric cavities can be detected in different membrane compositions, and lipid tails play a role in ligand binding pose stability and cavity size.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Biochemistry & Molecular Biology
Aryan Kamal, Christian Arnold, Annique Claringbould, Rim Moussa, Nila H. Servaas, Maksim Kholmatov, Neha Daga, Daria Nogina, Sophia Mueller-Dott, Armando Reyes-Palomares, Giovanni Palla, Olga Sigalova, Daria Bunina, Caroline Pabst, Judith B. Zaugg
Summary: Enhancers are crucial for gene regulation and linked to noncoding genetic variants associated with complex traits. We lack a framework for jointly analyzing transcription factors and enhancers in cell-type-specific gene regulatory networks (GRN) and an unbiased way to evaluate the biological significance of inferred GRNs. To address these gaps, we introduce GRaNIE (Gene Regulatory Network Inference including Enhancers) and GRaNPA (Gene Regulatory Network Performance Analysis). Our methods are demonstrated by studying gene regulatory mechanisms in macrophage response to infection, cancer, and common genetic traits. Furthermore, we identify the TF PURA as a potential regulator of pro-inflammatory macrophage polarization.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Oncology
Maria Luz Morales, Roberto Garcia-Vicente, Alba Rodriguez-Garcia, Armando Reyes-Palomares, Africa Vincelle-Nieto, Noemi alvarez, Alejandra Ortiz-Ruiz, Vanesa Garrido-Garcia, Alicia Gimenez, Gonzalo Carreno-Tarragona, Ricardo Sanchez, Rosa Ayala, Joaquin Martinez-Lopez, Maria Linares
Summary: Despite the approval of several drugs for AML, resistance to cytarabine is common. RNA splicing and phosphorylation of SR proteins were found to be altered during cytarabine resistance. Inhibition of RNA splicing, alone or in combination with venetoclax, could be a potential treatment strategy for AML.
Meeting Abstract
Obstetrics & Gynecology
A. Reyes Palomares, A. Castillo-Dominguez, A. Reyes-Engel, A. Reyes-Palomares
HUMAN REPRODUCTION
(2017)
Article
Biophysics
Carlos Acosta-Andrade, Ibai Artetxe, Marta G. Lete, Bingen G. Monasterio, Kepa Ruiz-Mirazo, Felix M. Goni, Francisca Sanchez-Jimenez
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
