4.7 Article

A prospective fMRI-based technique for localising the epileptogenic zone in presurgical evaluation of epilepsy

期刊

NEUROIMAGE
卷 113, 期 -, 页码 329-339

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.03.011

关键词

Presurgical evaluation; fMRI; ICA; LS-SVM

资金

  1. Research Council KUL [CoE PFV/10/002]
  2. Flemish Government: FWO: projects [G.0427.10N, G. 0108.11, G.0869.12N, G.0A5513N]
  3. IWT: projects [TBM 080658-MRI, TBM 110697-NeoGuard]
  4. iMinds Medical Information Technologies SBO, ICON: NXT_Sleep
  5. Flanders Care: Demonstratieproject Tele-Rehab III
  6. Belgian Federal Science Policy Office [IUAP P7/19]
  7. Belgian Foreign Affairs-Development Cooperation: VLIR UOS programs
  8. European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC Advanced Grant: BIOTENSORS [339804]
  9. EU: INTERREG IVB NWE programme, MC ITN TRANSACT, ERASMUS EQR: Community service engineer [RECAP 209G, 316679, 539642-LLP-1-2013]

向作者/读者索取更多资源

There is growing evidence for the benefits of simultaneous EEG-fMRI as a non-invasive localising tool in the presurgical evaluation of epilepsy. However, many EEG-fMRI studies fail due to the absence of interictal epileptic discharges (IEDs) on EEG. Herewe present an algorithm which makes use of fMRI as sole modality to localise the epileptogenic zone (EZ). Recent studies using various model-based or data-driven fMRI analysis techniques showed that it is feasible to find activation maps which are helpful in the detection of the EZ. However, there is lack of evidence that these techniques can be used prospectively, due to (a) their low specificity, (b) selecting multiple activation maps, or (c) a widespread epileptic network indicated by the selected maps. In the current study we present a method based on independent component analysis and a cascade of classifiers that exclusively detects a single map related to interictal epileptic brain activity. In order to establish the sensitivity and specificity of the proposed method, it was evaluated on a group of 18 EEG-negative patients with a single well-defined EZ and 13 healthy controls. The results show that our method provides maps which correctly indicate the EZ in several (N = 4) EEG-negative cases but at the same time maintaining a high specificity (92%). We conclude that our fMRI-based approach can be used in a prospective manner, and can extend the applicability of fMRI to EEG-negative cases. (C) 2015 Elsevier Inc. All rights reserved.

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