Article
Anatomy & Morphology
Maria J. Luesma, Irene Cantarero, Ana I. Sanchez-Cano, Clementina Rodellar, Concepcion Junquera
Summary: The three-dimensional ultrastructure of tendons is complex, with the presence of telocytes, a specific type of interstitial cell, near blood vessels. These telocytes have characteristic telopodes and can release exosomes, potentially playing a special role in tendon homeostasis.
JOURNAL OF ANATOMY
(2021)
Article
Chemistry, Physical
Jin-Hu Dou, Maxx Q. Arguilla, Yi Luo, Jian Li, Weizhe Zhang, Lei Sun, Jenna L. Mancuso, Luming Yang, Tianyang Chen, Lucas R. Parent, Grigorii Skorupskii, Nicole J. Libretto, Chenyue Sun, Min Chieh Yang, Phat Vinh Dip, Edward J. Brignole, Jeffrey T. Miller, Jing Kong, Christopher H. Hendon, Junliang Sun, Mircea Dinca
Summary: Researchers have successfully grown single crystals of 2D metal-organic frameworks up to 200 µm in size by balancing in-plane and out-of-plane interactions, revealing anisotropic transport and a clear correlation between conductivity and the nature of the metal cation in the sheets.
Article
Cell Biology
Eric Tambutte, Philippe Ganot, Alexander A. Venn, Sylvie Tambutte
Summary: Cilia, evolutionarily conserved organelles found in diverse organisms, have different structures in the calcifying epithelium of corals, where they are considered to be primary cilia. This may have important implications for understanding the cellular physiology driving coral calcification and its sensitivity to the environment.
CELL AND TISSUE RESEARCH
(2021)
Article
Chemistry, Physical
Zonglin Li, Mingxin Xie, Guozheng Nie, Junhui Wang, Lujun Huang
Summary: In this study, we developed an optical biosensor based on an all-dielectric metasurface with broken symmetry. The biosensor exhibited excellent performance, thanks to the high-Q quasi-bound states in the continuum (qBICs) and the efficient field confinement. It has potential applications in extreme biochemical sensing, such as COVID-19 detection at ultralow concentrations.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Ying Xu, Hu Tian, Guangliang Qiao, Wenjie Zheng
Summary: This study characterized the morphology and ultrastructure of telocytes in atherosclerotic arteries using immunofluorescence and transmission electron microscopy techniques. The results showed changes in telocytes in atherosclerotic arteries, with larger cell bodies, shorter telopodes, and the presence of lipidosomes.
Review
Cell Biology
Bo Wang, Zheyong Liang, Peijun Liu
Summary: This article reviews the role of the primary cilium in cancer, including its architecture, signaling pathways, cilia assembly and disassembly regulators, summarizing new findings in tumor microenvironments and different cancers, highlighting novel possibilities for therapeutic targets in cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Lin Song, Fritz Appel, Florian Pyczak, Zhanbing He, Junpin Lin, Tiebang Zhang
Summary: This study revealed a novel internal twinning mechanism of the alpha(2) phase in a TiAl alloy deformed at high temperature, showing three generations of twins. The findings shed light on the ductility of the alloy and provide important information on the complex twinning mechanisms in hexagonal structures.
Article
Chemistry, Multidisciplinary
Mengyu Gao, Yoonjae Park, Jianbo Jin, Peng-Cheng Chen, Hannah Devyldere, Yao Yang, Chengyu Song, Zhenni Lin, Qiuchen Zhao, Martin Siron, Mary C. Scott, David T. Limmer, Peidong Yang
Summary: Halide perovskite is a unique dynamical system with complex structural and chemical processes, but its intrinsic instability makes real-time investigation challenging. However, our research reveals that atomically thin carbon materials can stabilize ultrathin halide perovskite nanostructures and enable atomic-level visualization of their movement. Protected by carbon shells, these structures maintain their integrity under high electron dose rate and exhibit unusual dynamical behaviors. Our work provides a new method to protect beam-sensitive materials and study structure dynamics of nanomaterials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Chun Bian, Xinyue Zhao, Yaping Liu, Minjiang Chen, Shuying Zheng, Xinlun Tian, Kai-Feng Xu
Summary: Neurofibromatosis rarely involves the lungs, but in cases with lung involvement, other diagnoses such as primary ciliary dyskinesia (PCD) should be considered. Early-onset wet cough, bronchiectasis, and other symptoms may indicate the possibility of PCD.
FRONTIERS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andreia L. Pinto, Margarida Rasteiro, Catarina Bota, Sara Pestana, Pedro Sampaio, Claire Hogg, Thomas Burgoyne, Susana S. Lopes
Summary: Zebrafish, a widely used vertebrate teleost in research, presents unique advantages such as sustained transparency for at least 48 hours post fertilization. This study validates zebrafish motile cilia as organelles for Primary Ciliary Dyskinesia (PCD) research and characterizes different types of cilia in the olfactory pit and left-right organizer. The findings demonstrate the potential of zebrafish as a model organism for understanding human diseases and highlight the importance of considering specific physical differences for accurate interpretation of research results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hao-Chin Huang, Kai-Yuan Hsiao, Yu-Han Tseng, Yan-De Chen, Ming-Yen Lu
Summary: In this study, an in situ transmission electron microscopy (TEM) heating system was used to investigate the morphological changes of cubic Ag nanoparticles (NPs) and Ag-based core-shell structures induced by sublimation, as well as the influence of shell coverage on thermal stability. It was found that large Ag NPs (>50 nm) showed a three-stage sublimation-induced morphological change, while small Ag NPs (<30 nm) showed a uniform sublimation. The sublimation process of core-shell NPs started at stage II, and the thermal stability was enhanced by carbon shell passivation.
Article
Chemistry, Physical
Xin Luo, Ruixin Hao, Hao Wang, Wenbo Zhai, Zeyu Wang, Zhijun Ning, Yi Yu
Summary: By utilizing low dose in situ high-resolution transmission electron microscopy imaging, we directly observed the nucleation and growth process of the phase transition from orthorhombic gamma-CsPbBr3 to cubic alpha-CsPbBr3 in nanoplates during heating. The normalization of (PbBr6)(4-) octahedra was observed, and phase transition pathways (edge-to-center growth and island growth) were summarized. Phase fluctuation/recovery occurs during the phase transition process. Additionally, we investigated the thermal degradation caused by high temperature, which was found to occur from the outer edge to the center region. This work provides a microscopic basis for the understanding of phase transition and its application in devices.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Food Science & Technology
Amal S. Albedwawi, Reem Al Sakkaf, Tareq M. Osaili, Ahmed Yusuf, Amin Olaimat, Shao-Quan Liu, Giovanni Palmisano, Nagendra P. Shah, Mutamed M. Ayyash
Summary: This paper investigated the ability of lactic acid bacteria (LAB) and Bifidobacterium to remove acrylamide (AA) and examined the mechanism(s) of the AA removal using various microscopic techniques. The results showed that Bifidobacterium breve and Lactiplantibacillus plantarum exhibited higher acrylamide reduction rates. The study also found that both strains could tolerate low pH levels and remove acrylamide under in vitro gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Rosana Blanco-Manez, Miguel Armengot-Carceller, Teresa Jaijo, Francisco Vera-Sempere
Summary: Diagnosis testing for primary ciliary dyskinesia (PCD) involves multiple investigations, including high-speed video-microscopy, genetic testing, and transmission electron microscopy (TEM). However, some PCD variants cannot be diagnosed through TEM, which was traditionally considered the gold standard. This study identified a previously undescribed axonemal defect that affects peripheral doublets tilting, present in both PCD-confirmed patients and those with normal ultrastructure PCD subtypes. The analysis of axonemal asymmetry could enhance the diagnosis of PCD.
Article
Materials Science, Multidisciplinary
Oana Cojocaru-Miredin, Arun Devaraj
Summary: In the past decade, the applicability of atom probe tomography (APT) has been extended to a wide range of materials including semiconductors and insulators. However, APT can only provide information about composition, making it challenging to analyze the correlation between composition and other material properties. Therefore, researchers worldwide have been combining APT with other microscopy methods to understand the composition-property interrelationships at the same position of the sample. This article provides an overview of these efforts and presents three examples of opportunities in materials science when using correlative microscopy with APT.
Article
Anatomy & Morphology
Maria J. Luesma, Irene Cantarero, Ana I. Sanchez-Cano, Clementina Rodellar, Concepcion Junquera
Summary: The three-dimensional ultrastructure of tendons is complex, with the presence of telocytes, a specific type of interstitial cell, near blood vessels. These telocytes have characteristic telopodes and can release exosomes, potentially playing a special role in tendon homeostasis.
JOURNAL OF ANATOMY
(2021)
Article
Cell Biology
Pablo Iruzubieta, Irene Cantarero, Marta Monzon, Manuel Lahoz, Concepcion Junquera
Summary: In this study, we investigated adult neurogenesis in the enteric nervous system (ENS) of humans using ultrastructural and immunohistochemical techniques. We found markers of immature neurons in the ENS, supporting the existence of adult neurogenesis. Additionally, our findings suggest that Interstitial Cells of Cajal (ICCs) may serve as the original neural stem cells, generating newly-born neurons through asymmetrical cell division.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Maria Jose Luesma, Ines Gale, Jose Fernando
Summary: Pudendal nerve entrapment syndrome can be easily misdiagnosed or confused with other pelvic floor diseases, requiring a detailed history and physical examination for diagnosis and treatment. Treatment includes lifestyle changes, drug therapy, and physiotherapy, with invasive therapies as an option for failure of conservative measures.
Review
Medicine, General & Internal
Sonia Santander Ballestin, David Gomez Martin, Sara Lorente Perez, Maria Jose Luesma Bartolome
Summary: Newly introduced combination therapies for hepatitis C exhibit high safety, effectiveness, and shorter treatment duration, proving to be effective for previously treated or compensated cirrhotic patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Sonia Santander Ballestin, Marta Isabel Gimenez Campos, Jara Ballestin Ballestin, Maria Jose Luesma Bartolome
Summary: Proper nutrition during pregnancy is crucial for both maternal and fetal health, and micronutrient supplementation can help prevent congenital defects and other diseases. However, adjustments to recommended intake levels are needed based on experimental studies.
Article
Surgery
Jose Fernando Trebolle, Carlos Yanez Benitez, Monica Valero Sabater, Beatriz Cros Montalban, Irene Cantarero Carmona, Maria Jose Luesma Bartolome, Jorge Garcia Egea, Ana Nogues Pevidal, Issa Talal El-Abur, Juan Luis Blas Laina
Summary: Efficient teamwork and a culture of safety are crucial for avoiding intraoperative complications during complex laparoscopic surgical procedures, highlighting the importance of effective communication among surgical team members.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Anatomy & Morphology
Tomas Castiella, Pablo Iruzubieta, Eva Monleon, M. Jose Cardiel, Jesus Gomez-Vallejo, Marta Monzon, Ma Concepcion Junquera
Summary: Giant cell tumor of bone (GCTB) contains primary cilia in tumoral stromal cells, with Hedgehog signaling pathway activation observed. This indicates the significant role of primary cilia in GCTB tumorigenesis through Hh signaling in stromal cells.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Review
Medicine, General & Internal
Sonia Santander Ballestin, Andrea Lanuza Bardaji, Cristina Marco Continente, Maria Jose Luesma Bartolome
Summary: The stress response and immunosuppression caused by surgical aggression and anesthetic agents can lead to inadvertent dispersion and progression of tumors. Inhaled anesthetics and opioids have been found to benefit immunosuppression, cell proliferation, and angiogenesis, creating an ideal environment for tumor progression. However, the potential benefits of reducing their use and exploring alternative anesthetic techniques to protect patients from metastasis are still being investigated.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nuria Sarroca, Maria Jose Luesma, Jose Valero, Maria Pilar del Caso, Cristina Alonso, Jorge Calleja, Tania Lorenzo, Javier Bayod, Manuel Lahoz
Summary: People with lower limb amputation have less stability than able-bodied individuals in a static situation. Rigid insoles improve stability in amputees, while soft insoles decrease stability.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Maria Jose Luesma, Jose Fernando, Irene Cantarero, Pilar Lucea, Sonia Santander
Summary: The prevalence of obesity has been increasing rapidly in recent decades, making it one of the most impacting diseases on global health. It is a chronic disease associated with various comorbidities that result in a reduced life expectancy and quality of life. The treatment of obesity requires a multidisciplinary approach by a specialized medical team and can be done through conservative or surgical treatments. Vertical gastrectomy, mixed techniques, and gastric bypass are the most commonly used surgical techniques. The choice of technique should consider the characteristics of each patient and the surgical team's experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Marta Baselga, Eduardo Moreo, Iratxe Uranga-Murillo, Maykel Arias, Concepcion Junquera
Summary: This study aims to investigate the structural and functional response of the cytoskeleton in cells infected with the SARS-CoV-2 virus. By observing viral propagation events between cells, a better understanding of the clinical manifestations of COVID-19 disease and the development of new therapeutic strategies can be achieved.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angela Feiner Solis, Ana Avedillo Salas, Maria Jose Luesma Bartolome, Sonia Santander Ballestin
Summary: This systematic review examines the impact of vitamin D supplementation on the disease course of COVID-19. The results suggest that regardless of initial vitamin D serum levels, patients benefit from vitamin D supplementation, although the outcomes are inconsistent and larger clinical trials are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Sonia Santander Ballestin, Maria Jose Luesma Bartolome
Summary: Some chemical components in sun cream filters have potential risks to health and the environment. This study compares conventional commercial sunscreens with natural products in terms of their endocrine-disrupting effects. Different sun cream filters were evaluated and compared, considering safety assessments from Environmental Working Group and the EU Registration, Evaluation, Authorization and Restriction of Chemicals Regulation. While some organic sun cream filters pose risks, inorganic filters like titanium dioxide and zinc oxide have very low risk as they are not absorbed through intact or damaged tissues. However, the legislation does not require manufacturers to specify the concentration of each substance, providing limited information for consumers.
APPLIED SCIENCES-BASEL
(2023)
