期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 15, 期 8, 页码 1636-1644出版社
WILEY
DOI: 10.1111/j.1582-4934.2011.01317.x
关键词
glioblastoma; microRNAs; prognosis; prediction; therapeutic targets
资金
- Czech Ministry of Health [IGA NT/11214-4/2010, IGA NR 9875-4, MZ0MOU2005]
- CEITEC - Central European Institute of Technology [CZ.1.05/1.1.00/02.0068]
- Operational Programme Research and Development for Innovations [CZ.1.05/2.1.00/01.0030]
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据