期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 12, 期 6A, 页码 2519-2521出版社
WILEY
DOI: 10.1111/j.1582-4934.2008.00498.x
关键词
freeze-fracture electron microscopy; immunogold cytochemistry; caveolin-1; caveolin-3; cardiomyocytes
资金
- Deutsche Forschungsgemeinschaft [SFB 492]
- British Heart Foundation [PG/08/048/25093]
Mutations in or ablation of the gene encoding caveolin-3, a protein of muscle cell caveolae, result in forms of muscular dystrophy and cardiomyopathy. Another member of the caveolin gene family, caveolin-1, is widely considered not to be expressed in myocytes, yet ablation of the gene encoding this protein in mice also results in cardiomyopathy. By applying the high-resolution electron-microscopical imaging technique of freeze-fracture replica immunolabelling, we report here evidence that caveolin-1 is expressed in human cardiac myocytes, localized to both caveolae and non-caveolar domains in the plasma membrane. Disorders of the myocyte resulting from defects in caveolin-1 may thus arise directly, at the level of the myocyte, rather than via other cell types as previously proposed.
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