Article
Multidisciplinary Sciences
Fangyi Shi, Noof Aloufi, Hussein Traboulsi, Jean-Francois Trempe, David H. Eidelman, Carolyn J. Baglole
Summary: The study revealed that AhR deficiency increases basal Akt kinase phosphorylation in mouse lung fibroblasts but does not affect Akt phosphorylation under growth factor or AhR ligand stimulation. Furthermore, AhR may modulate the phosphorylation of various novel proteins, influencing cell survival and function through unknown mechanisms.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Ryan R. Kowash, Esra A. Akbay
Summary: The adenosine pathway, particularly CD73, is a promising target for cancer immunotherapy, especially in non-small cell lung cancer (NSCLC) where CD73 expression is high. Combining immune checkpoint blockade (ICB) therapies with adenosine pathway inhibitors shows potential for the treatment of lung cancer. Clinical trials exploring the activation of both T and NK cells are in early stages. Understanding the role of CD73 in immune modulation and its intrinsic properties in tumor cells is important for future therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iksen, Sutthaorn Pothongsrisit, Varisa Pongrakhananon
Summary: Lung cancer is a common and highly lethal cancer, posing a major clinical challenge. The PI3K/AKT/mTOR pathway has been linked to lung cancer, making it a significant therapeutic target. Interest in targeting these pathways with medications has grown, showing promise in various types of studies.
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S. Subramanian, Anshu Agrawal
Summary: Vitamin C exerts its antiviral and protective functions in the lungs by upregulating metabolic pathways and interferon-stimulated genes, while simultaneously downregulating pathways related to lung injury and inflammation. Additionally, vitamin C enhances the expression of viral-sensing receptors, contributing to its antiviral effects.
Article
Dermatology
Ye Liu, Wenna Chi, Lei Tao, Guoqiang Wang, R. N. V. Krishna Deepak, Linlin Sheng, Taiqi Chen, Yaqian Feng, Xizhi Cao, Lili Cheng, Xinbin Zhao, Xiaohui Liu, Haiteng Deng, Hao Fan, Peng Jiang, Ligong Chen
Summary: Sequence variation in SLC45A2 is associated with oculocutaneous albinism type 4 and melanoma susceptibility. The study reveals that SLC45A2 plays a critical role in melanogenesis and melanoma metastasis. Slc45a2-deficient melanocytes have impaired activity of the key melanogenic enzyme tyrosinase due to the acidified cellular environment. SLC45A2 is identified as a proton/glucose exporter in melanosomes, and its deficiency leads to increased acidification of melanosomal pH through enhanced glycolysis. Additionally, Slc45a2 deficiency upregulates glycolytic enzymes and PI3K/AKT signaling, promoting glycolysis-dependent survival and metastasis of melanoma cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Shi, Anne Berking, Timo Baade, Kyle R. Legate, Reinhard Fassler, Christof R. Hauck
Summary: Staphylococcus aureus invades host cells mainly through an integrin-dependent manner, with phosphatidylinositol-4,5-bisphosphate (PI-4,5-P-2) playing a significant role in regulating integrin-associated proteins. Local synthesis of PI-4,5-P-2 by a focal adhesion-associated lipid kinase is crucial for integrin-mediated internalization of S. aureus. Targeting active PI-4,5-P-2 phosphatase to the plasma membrane and specific ablation of talin and FAK-binding motif in PIP5KI gamma 90 can reduce bacterial invasion.
MOLECULAR MICROBIOLOGY
(2021)
Article
Cell Biology
Ryoko Sato-Nishiuchi, Masamichi Doiguchi, Nanami Morooka, Kiyotoshi Sekiguchi
Summary: Polydom is an extracellular matrix protein involved in lymphatic vessel development. In this study, it was found that Polydom directly binds to Tie1, a receptor in the Angiopoietin-Tie system, and promotes lymphatic endothelial cell migration. The PI3K/Akt pathway is involved in Polydom-induced LEC migration. These findings suggest that Polydom plays a crucial role in lymphatic vessel development through Tie1 and the PI3K/Akt pathway.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Supharada Tessiri, Anchalee Techasen, Sarinya Kongpetch, Achira Namjan, Watcharin Loilome, Waraporn Chan-On, Raynoo Thanan, Apinya Jusakul
Summary: This study revealed the association between genetic alterations in ARID1A and the activation of the PI3K/AKT pathway in cholangiocarcinoma (CCA). It also found that CCA cells deficient in ARID1A were more sensitive to AKT inhibition.
Article
Gastroenterology & Hepatology
Nurul Nadirah Razali, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Azyani Yahaya, Norshafila Diana Mohd Rathi, Norfilza Mohd Mokhtar
Summary: This study found that rs10889677 variant serves as a critical initiator of the PI3K signaling pathway, and buparlisib has the ability to prevent PI3K-non-AKT activation in the pathophysiology of CAC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Integrative & Complementary Medicine
Hong-xiao Li, Ling Shi, Shang-jie Liang, Chen-chen Fang, Qian-qian Xu, Ge Lu, Qian Wang, Jie Cheng, Jie Shen, Mei-hong Shen
Summary: Moxibustion improved ovarian function and suppressed apoptosis of ovarian granulosa cells in a rat model of DOR induced by TGS, and the mechanism may involve the PI3K/AKT signaling pathway.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Cell Biology
Jianyang Xiang, Wahafu Alafate, Wei Wu, Yichang Wang, Xiaodong Li, Wanfu Xie, Xiaobin Bai, Ruichun Li, Maode Wang, Jia Wang
Summary: NEK2 is significantly upregulated in glioblastoma (GBM) and higher expression of NEK2 is associated with poor prognosis. Knockdown of NEK2 attenuates proliferation, migration, invasion, and tumorigenesis of GBM, while overexpression of NEK2 promotes GBM progression. NEK2 is positively related to the NF-kappa B signaling pathway in GBM.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Ahmad Aljohmani, Noah Niklas Andres, Daniela Yildiz
Summary: Severe epithelial dysfunction is a major feature in the progress of bacterial pneumonia. The activation of ADAM17 plays a critical role in the infection of lung epithelial cells by Pseudomonas aeruginosa, and targeting ADAM17 may be a potential therapeutic option.
Review
Pharmacology & Pharmacy
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash
Summary: Genetic and epigenetic alterations have long been the focus of cancer pathogenesis research, with dysregulated genes and protein products potentially affecting cancer cell growth through signaling cascades regulating cell survival and metabolism. The activation of the phosphatidylinositol-3-kinase (PI3K) axis in about one-third of human cancers, including gastric cancer, plays a significant role in the development of malignancies. This indicates the potential importance of targeting this axis in therapeutic strategies for such cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingying Wang, Yongqiang Hou, Lanjiao Hou, Wei Wang, Ke Li, Zhe Zhang, Bo Du, Dexin Kong
Summary: Digoxin exhibits antitumor effects on non-small cell lung cancer cell lines by inhibiting proliferation, migration, invasion, while inducing apoptosis and autophagy. Further evidence is needed to support its potential therapeutic use for lung cancer.
BIOSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yan Yan, Tingting Gu, Stine Duelund Kaas Christensen, Junyi Su, Thomas Ravn Lassen, Marie Vognstoft Hjortbak, IJu Lo, Susanne Trillingsgaard Veno, Andrea Erzsebet Toth, Ping Song, Morten Schallburg Nielsen, Hans Erik Botker, Blagoy Blagoev, Kim Ryun Drasbek, Jorgen Kjems
Summary: Remote ischemic conditioning can attenuate ischemic-reperfusion injury by regulating the release of extracellular vesicles (EVs) from cells to provide protective function to damaged organs. This study showed that cyclic hypoxia-reoxygenation (HR) induced changes in the miRNA and protein profile of EVs released by C2C12 cells, enhancing the protective signal to recipient cells in vitro. Additionally, HR EV treatment restored cell viability, reduced inflammation, and improved tube formation in in vitro assays.
