Article
Medicine, Research & Experimental
Etienne Delangre, Gaelle Pommier, Stefania Tolu, Benjamin Uzan, Danielle Bailbe, Jamileh Movassat
Summary: In this study, the effects of lithium chloride (LiCl) on glucocorticoid-induced metabolic disorders were investigated using rat models. The results showed that lithium significantly reduced insulin resistance and improved glucose tolerance, accompanied by decreased hepatic gluconeogenesis. In addition, lithium enhanced insulin secretion. These findings demonstrate the beneficial effects of lithium in mitigating the adverse metabolic effects of chronic glucocorticoid therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Dewei Ye, Jiating Huang, Jiaming Wu, Kang Xie, Xiang Gao, Kaixuan Yan, Pengfei Zhang, Ying Tao, Yun Li, Shufei Zang, Xianglu Rong, Jun Li, Jiao Guo
Summary: Gestational diabetes mellitus (GDM) is a condition characterized by high blood sugar and insulin resistance during the second or third trimester of pregnancy, which poses significant risks to both the mother and fetus. Through a study on a group of pregnant women with GDM and those with normal glucose tolerance (NGT), we discovered microbial and metabolic alterations associated with GDM. These findings provide insight into the mechanistic link between altered gut microbiota and GDM, and suggest that targeting the gut microbiota could be a promising intervention for GDM.
Article
Biochemistry & Molecular Biology
Jerad Dumolt, Theresa L. Powell, Thomas Jansson, Fredrick J. Rosario
Summary: Infants born to obese mothers have a higher risk of childhood obesity and insulin resistance. Lower levels of maternal adiponectin, a hormone associated with placental nutrient transport and fetal overgrowth, contribute to these risks. Previous research showed that supplementing adiponectin in obese mice during pregnancy prevented obesity and metabolic dysfunction in their offspring. This study further demonstrates the importance of maternal adiponectin levels in the development of metabolic diseases in offspring and suggests that improving these levels could prevent long-term metabolic dysfunction in children of obese mothers.
Article
Cardiac & Cardiovascular Systems
Elahe Zare, Parvaneh Kafshbani, Maryam Chenaghlou, Mehdi Noori, Zahra Ghaemmaghami, Ahmad Amin, Sepideh Taghavi, Nasim Naderi
Summary: This study investigated the relationship between IR and glucose intolerance with PH. The high prevalence of IR in PH patients was observed, but it was not an independent predictor of death.
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Cell Biology
Quiana C. Wilkerson-Vidal, Madushika Wimalarathne, Genoah Collins, James Gerard Wolfsberger, Amelia Clopp, Luis Mercado, Evann Fowler, Helen Gibson, Victoria McConnell, Sidney Martin, Emily C. Hunt, Bernhard Vogler, Sharifa T. Love-Rutledge
Summary: This study found that young adult 1WR1 rats develop impaired glucose tolerance due to poor regulation of insulin, possibly indicating underlying insulin resistance. After 8 weeks, 1WR1 rats showed significantly reduced glucose tolerance, increased body mass, and increased levels of circulating insulin and glucagon proteins. However, the beta cell area in the 1WR1 rats was significantly reduced.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Vipin A. Vidyadharan, Ancizar Betancourt, Craig Smith, Chandrasekhar Yallampalli, Chellakkan S. Blesson
Summary: Gestational low-protein diet disrupts mitochondrial ultrastructure and function in skeletal muscles of female offspring, potentially leading to insulin resistance. Key genes involved in mitochondrial structure and function are dysregulated in LP-programmed female offspring.
Article
Biochemistry & Molecular Biology
Valeria Fridman D'Alessandro, Atsuro Takeshita, Taro Yasuma, Masaaki Toda, Corina N. D'Alessandro-Gabazza, Yuko Okano, Suphachai Tharavecharak, Chisa Inoue, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Yutaka Yano, Esteban C. Gabazza
Summary: Diabetic nephropathy, a common complication of diabetes mellitus, is the leading cause of end-stage renal disease. The overexpression of transforming growth factor beta 1 is associated with insulin resistance and rapid progression of kidney fibrosis under diabetic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
Summary: This study found that DEHP exposure exacerbated metabolic disorders in obese mice, but not in lean mice. The synergistic effects of obesity and DEHP regulated carbohydrate uptake, lipolysis, and abnormal adipose tissue, while obesity and DEHP differentially modulated transcriptomic changes in hepatic tissue.Obesity and DEHP exposure together caused early onset of metabolic disorders in obese mice through a potential mechanism involving Pparg, Lipe, Cd44, and Irs1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Sriram Gubbi, Ranganath Muniyappa, Susmeeta T. Sharma, Shivraj Grewal, Raven McGlotten, Lynnette K. Nieman
Summary: Short-term administration of mifepristone improved adipose and hepatic insulin sensitivity in obese individuals with hyperglycemia but without hypercortisolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Na Li, Chunhua Lu, Yuhang Ma, Xuejiao Wang, Yunxia Ling, Yanhua Yin, Shumei Li, Jiao Huang, Lihua Yu, Weiping Dong, Huichen He, Mei Kang, Lei Ma, Mingyu Gu, Li Zhao, Yunhong Huang, Fang Liu, Yufan Wang, Xianying Gai, Junyi Jiang, Yongde Peng, Xiaoying Ding
Summary: This study aims to examine the predictive factors associated with the progression from different prediabetic status to diabetes. The results showed that individuals with combined IFG and IGT were at a higher risk of progressing to diabetes compared to those with IFG alone. Males, obese individuals, higher BMI and WHR, and hypertension were positively associated with the progression to diabetes, while HOMA-b was negatively associated with the progression to diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Domenico Trico, Alessandro Mengozzi, Simona Baldi, Roberto Bizzotto, Oladapo Olaniru, Klaudia Toczyska, Guo Cai Huang, Marta Seghieri, Silvia Frascerra, Stephanie A. Amiel, Shanta Persaud, Peter Jones, Andrea Mari, Andrea Natali
Summary: The study found that mild acute hypertriglyceridemia impairs oral glucose tolerance and whole-body insulin sensitivity, resulting in increased post-glucose hyperinsulinemia due to reduced insulin clearance and enhanced hyperglycemia-induced total insulin secretion. Additionally, high-physiologic triglyceride levels can increase insulin secretion.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Alper Sonmez, Teoman Dogru, Cemal Nuri Ercin, Halil Genc, Gurkan Celebi, Hasan Gurel, Serkan Tapan, Ali Fuat Cicek, Cem Barcin, Cem Haymana, Ali Kirik, Manfredi Rizzo
Summary: Betatrophin levels are higher in the early stages of NAFLD, positively correlated with age, waist circumference, lipid profile, glucose, insulin, and liver function, and negatively correlated with steatosis and NAS. Triglyceride, glucose, and NAS are independent determinants of betatrophin levels.
Article
Endocrinology & Metabolism
Sharona Tornovsky-Babeay, Noa Weinberg-Corem, Rachel Ben-Haroush Schyr, Dana Avrahami, Judith Lavi, Eseye Feleke, Klaus H. Kaestner, Yuval Dor, Benjamin Glaser
Summary: Activating GCK in mice led to increased beta cell proliferation, random and fasting hypoglycemia, and ultimately impaired glucose tolerance and decreased beta cell mass, suggesting a biphasic response where increased workload initially stimulates beta cell proliferation but eventually leads to dysfunction potentially due to metabolic stress.
Article
Nutrition & Dietetics
Ying-Chen Huang, Tung-Lung Wu, Huawei Zeng, Wen-Hsing Cheng
Summary: The study found that mice fed diets containing <= 0.10 mg Se/kg displayed impaired glucose tolerance and insulin sensitivity, suggesting increased susceptibility to type 2 diabetes by suboptimal Se status at levels <= 23% of nutritional needs.
JOURNAL OF NUTRITION
(2021)
Article
Cell Biology
Alonso Sanchez-Cruz, Alberto Hernandez-Pinto, Concepcion Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fatima Bosch, Pedro de la Villa, Catalina Hernandez-Sanchez, Enrique J. de la Rosa
Summary: Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Impaired insulin receptor signaling has been linked to retinitis pigmentosa (RP). Decreased levels of the insulin receptor and its downstream effector phospho-S6 were observed in a mouse model of RP, along with abnormal synapses between photoreceptors and other cells. Gene therapy using proinsulin restored retinal insulin receptor signaling, preserved synaptic connectivity, and prolonged visual function in RP mice.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Teresa Vanessa Fiorentino, Francesca De Vito, Evelina Suraci, Raffaella Marasco, Marta Letizia Hribal, Francesco Luzza, Giorgio Sesti
Summary: This study found that individuals with overweight and obesity have higher protein levels of SGLT-1, GLUT-2, and GLUT-5 in the duodenum compared to lean individuals. These protein levels are positively correlated with body weight, waist circumference, postprandial glucose, insulin levels, and insulin resistance. The results suggest that increased duodenal SGLT-1 and GLUT-5 abundance in overweight and obese individuals may contribute to higher postprandial glucose concentrations, insulin resistance, and hyperinsulinemia.
Review
Chemistry, Medicinal
Aikaterini Andreadi, Saverio Muscoli, Rojin Tajmir, Marco Meloni, Alessandro Minasi, Carolina Muscoli, Sara Ilari, Vincenzo Mollace, David Della Morte, Alfonso Bellia, Elena Campione, Nicola Di Daniele, Davide Lauro
Summary: The link between acne and insulin resistance in males has not been studied as extensively as in females, despite the increasing prevalence of acne in adult men. Metformin, a medication that increases insulin sensitivity, may affect the relationship between acne vulgaris and insulin resistance. However, further clinical studies are needed to confirm these assumptions.
Editorial Material
Medicine, General & Internal
Giovambattista Desideri, Giorgio Sesti
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Francesca De Vito, Velia Cassano, Elettra Mancuso, Elena Succurro, Marta Letizia Hribal, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino
Summary: Higher pro-NT levels are a predictor of NAFLD independent of other metabolic risk factors.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cell Biology
Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di Daniele, Enrico Garaci, Massimiliano Caprio, David Della-Morte
Summary: This study investigated the effects of a natural mixture of polyphenols and micronutrients (A5(+)) on counteracting white adipogenesis and promoting fat browning. The results showed that A5(+) significantly reduced lipids accumulation, inhibited cellular proliferation, and decreased the release of pro-inflammatory cytokines. Additionally, A5(+) promoted fat browning and fatty acid oxidation by increasing the expression of genes related to brown adipose tissue.
Article
Health Care Sciences & Services
Saverio Muscoli, Aikaterini Andreadi, Claudia Tamburro, Massimo Russo, Roberto Rosenfeld, Pietro Oro, Mihaela Ifrim, Federica Porzio, Lucy Barone, Francesco Barilla, Davide Lauro
Summary: This retrospective study examined cardiovascular risk factors and specific coronary findings in high-risk immigrant groups from Eastern Europe, the Middle East and North Africa, and South Asia. The results showed variations in cardiovascular disease among different ethnicities, with South Asians being particularly high-risk and other groups having lower cardiovascular risk factors. This study supports the role of genetic influence in these different ethnic communities.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Marco Meloni, Aikaterini Andreadi, Ermanno Bellizzi, Laura Giurato, Valeria Ruotolo, Maria Romano, Alfonso Bellia, Luigi Uccioli, Davide Lauro
Summary: This study aimed to evaluate the effectiveness of a multidisciplinary diabetic foot team (MDFT) in the management of in-patients with diabetic foot problems. The results showed that the rate of in-hospital complications (IHCs) in patients managed by MDFT was 8%, and patients with ischemic heart disease (IHD) and longer wound duration had a higher risk of IHCs.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Nikolaus Marx, Massimo Federici, Katharina Schuett, Dirk Mueller-Wieland, Ramzi A. Ajjan, Manuel J. Antunes, Ruxandra M. Christodorescu, Carolyn Crawford, Emanuele Di Angelantonio, Bjorn Eliasson, Christine Espinola-Klein, Laurent Fauchier, Martin Halle, William G. Herrington, Alexandra Kautzky-Willer, Ekaterini Lambrinou, Maciej Lesiak, Maddalena Lettino, Darren K. Mcguire, Wilfried Mullens, Bianca Rocca, Naveed Sattar
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Raffaele Antonelli Incalzi, Agostino Consoli, Pierluigi Lopalco, Stefania Maggi, Giorgio Sesti, Nicola Veronese, Massimo Volpe
Summary: This review summarizes the impact of influenza on vulnerable populations, emphasizing the benefits of influenza vaccination in preventing severe illness and complications. The efficacy, effectiveness, and safety of vaccines suitable for older adults in Italy are also reviewed. Although high-dose and adjuvanted influenza vaccines have been developed to enhance immune responses in older adults, vaccination coverage in high-risk populations remains suboptimal. Healthcare professionals play an important role in increasing vaccination rates.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, General & Internal
Francesca De Vito, Evelina Suraci, Raffaella Marasco, Francesco Luzza, Francesco Andreozzi, Giorgio Sesti, Teresa Vanessa Fiorentino
Summary: Increased levels of duodenal GLUT-5 are associated with NAFLD and liver fibrosis. Inhibition of intestinal GLUT-5-mediated fructose uptake may be a strategy for preventing and treating NAFLD.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marco Meloni, Laura Giurato, Aikaterini Andreadi, Ermanno Bellizzi, Alfonso Bellia, Davide Lauro, Luigi Uccioli
Summary: The current study evaluated the effectiveness of PB-MNC therapy as adjuvant treatment for patients with DFUs and NO-CLI. The results showed that adjuvant PB-MNC therapy promoted healing and improved tissue perfusion in patients with NO-CLI and neuro-ischaemic DFUs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti
Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.
Review
Endocrinology & Metabolism
Rossella Menghini, Viviana Casagrande, Stefano Rizza, Massimo Federici
Summary: High blood sugar strongly affects endothelial function and activation, increasing the risk of atherosclerotic cardiovascular disease. Glucagon-like peptide 1 receptor agonists (GLP-1RA), a class of drugs aimed at lowering blood glucose levels, show potential in improving endothelium damage and cardiovascular disease progression. They have direct favorable actions on coronary vascular endothelium, such as reducing oxidative stress and increasing nitric oxide. Further research is needed to understand the specific role of GLP-1RA in cardiovascular disease management and identify cellular targets involved in protective signal transmission.
ACTA DIABETOLOGICA
(2023)