期刊
JOURNAL OF CELL SCIENCE
卷 127, 期 21, 页码 4543-4548出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.151209
关键词
Regeneration; Satellite cells; Skeletal muscle; Stem cells; Therapy
类别
资金
- Queen Elizabeth II Graduate Scholarship in Science and Technology
- Canadian Institutes of Health Research
- National Institutes of Health
- Canadian Stem Cell Network
- Canada Research Chair Program
- Canadian Institutes for Health Research
Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar to other adult stem cells, understanding the molecular regulation of muscle stem cells has significant implications towards the development of pharmacological or cell-based therapies for muscle disorders. This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据