Editorial Material
Biochemistry & Molecular Biology
Rodrigo J. Gonzalez, Ulrich H. von Andrian
Summary: The interaction between GPR35 receptor and 5-HIAA serotonin metabolite promotes the recruitment of neutrophils from blood into inflamed tissues, which is significant for inflammation and anti-microbial host defense.
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Asif J. Iqbal, Franziska Krautter, Isobel A. Blacksell, Rachael D. Wright, Shani N. Austin-Williams, Mathieu-Benoit Voisin, Mohammed T. Hussain, Hannah L. Law, Toshiro Niki, Mitsuomi Hirashima, Michele Bombardieri, Costantino Pitzalis, Alok Tiwari, Gerard B. Nash, Lucy Norling, Dianne Cooper
Summary: This study investigates the role of immunomodulatory lectin Galectin-9 (Gal-9) in neutrophil recruitment. The results show that Gal-9 is upregulated in inflamed blood vessels and released by activated endothelial cells. Gal-9 binding induces neutrophil activation and can enhance their interaction with endothelial cells. Both soluble and immobilized Gal-9 function as adhesion molecules and can capture neutrophils. These findings provide insights into the importance of Gal-9 in leukocyte recruitment during inflammation.
Article
Immunology
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weissenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Summary: Beta 2 integrins play a crucial role in leukocyte trafficking by mediating the processes of slow rolling and firm arrest through conformational changes, which are regulated by interactions with Rap1 and Riam. The loss of both pathways simultaneously results in a rolling phenotype similar to talin1 deficient neutrophils, suggesting that these two pathways primarily regulate beta 2 integrin.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Young-Geun Choe, Jin-Hui Yoon, Jongyoon Joo, Bokyung Kim, Seon Pyo Hong, Gou Young Koh, Dong-Seok Lee, Wang-Yuhl Oh, Yong Jeong
Summary: The neurovascular unit, consisting of neurons, glial cells, pericytes, and endothelial cells, plays a crucial role in sustaining brain activity. However, the specific function of pericytes in regulating cerebral blood flow remains unclear. This study investigates the impact of pericyte loss on capillary stalling and the potential causes, such as changes in cerebral endothelial glycocalyx and leukocyte adhesion molecules. The results reveal that pericyte loss leads to increased capillary stalling and enhanced interaction between leukocytes and endothelial cells, ultimately resulting in cerebral hypoxia and gliosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon
Summary: In this study, the role of ICAM-1 and ICAM-2 in immune responses to influenza infection was investigated in mice. The results showed that lung capillary ICAMs were not essential for the entry of NK and neutrophils into virus-infected lungs. Additionally, ICAM-1 and ICAM-2 had little effect on the recruitment of naive T cells and B lymphocytes in mediastinal lymph nodes, but were critical for humoral immunity and the differentiation of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xianxian Wu, Xing Liu, Hang Yang, Qianlong Chen, Na Zhang, Yuhan Li, Xingchen Du, Xue Liu, Xiaoliang Jiang, Yideng Jiang, Zhou Zhou, Zhiwei Yang
Summary: Increased levels of PSGL-1 were observed in human and mouse aortic aneurysm. PSGL-1 deficiency reduced the incidence and severity of aortic aneurysm significantly, as well as decreased elastin fragmentation, collagen accumulation, and smooth muscle cells degeneration. The protective effect of PSGL-1 inhibition was mediated by the reduced adhesion molecules, leading to decreased inflammatory cells infiltration and decreased inflammatory factors expression.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Nadia Calabriso, Marika Massaro, Egeria Scoditti, Tiziano Verri, Amilcare Barca, Carmela Gerardi, Giovanna Giovinazzo, Maria Annunziata Carluccio
Summary: The study shows that polyphenolic extract from grape pomace can effectively alleviate inflammatory response in enterocyte-like cells and improve vascular function by inhibiting NF-kappa B activity and reducing intracellular ROS levels.
Article
Medicine, Research & Experimental
Adel Abo Mansour, Federica Raucci, Mustafa Sevim, Anella Saviano, Jenefa Begum, Zhaogong Zhi, Laleh Pezhman, Samantha Tull, Francesco Maione, Asif Jilani Iqbal
Summary: This study investigates the role of Gal-9 in the migration and adhesion of CD4+ and CD8+ T cells and reveals its potential therapeutic significance in inflammatory-based diseases. The findings suggest that Gal-9 supports T cell adhesion and transmigration in a glycan dependent manner and inhibits the chemotactic function of CXCL12 through direct binding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Martin Bernhard Mueller, Max Huebner, Lei Li, Stephanie Tomasi, Valena Liesske, David Effinger, Simon Hirschberger, Kristin Pogoda, Markus Sperandio, Simone Kreth
Summary: This study reveals a novel regulatory network in which miR-125a acts as a central hub to regulate endothelial barrier permeability and monocyte migration. The network involves the modulation of adhesion molecules, phosphatases, and transcription factors, leading to the opening of the endothelial barrier. Furthermore, miR-125a enhances the expression of a chemokine in endothelial cells, while suppressing its own expression in monocytes, resulting in enhanced monocyte chemotaxis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Laleh Pezhman, Abd Tahrani, Myriam Chimen
Summary: Type 2 Diabetes Mellitus is a chronic inflammatory disorder associated with obesity, insulin resistance, and hyperglycemia, with white blood cell accumulation in adipose tissue playing a key role in insulin resistance and beta-cell dysfunction. Therapeutic targeting of leukocyte trafficking may be an effective way to control inflammation, diabetes, and its vascular complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Laurent Calvier, Aleksandra Drelich, Jason Hsu, Chien-Te Tseng, Yair Mina, Avindra Nath, Maria Z. Kounnas, Joachim Herz
Summary: Thromboembolic complications and excessive inflammation in severe COVID-19 can lead to long COVID. This study found that Reelin is involved in endothelial dysfunction and hyperinflammation during COVID-19. Increased levels of Reelin in COVID-19 patients were correlated with disease activity. A hyperinflammatory state was observed in severe COVID-19 patients, with Reelin levels correlated with several inflammatory markers. Inhibiting Reelin with an anti-Reelin antibody reduced mortality and severity of disease in a mouse model infected with SARS-CoV-2, suggesting Reelin as a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephanie Tomasi, Lei Li, Ludwig Christian Hinske, Roland Tomasi, Martina Amini, Gabriele Strauss, Martin Bernhard Mueller, Simon Hirschberger, Sven Peterss, David Effinger, Kristin Pogoda, Simone Kreth, Max Huebner
Summary: During acute inflammation, the regulatory network driven by miR-125a affects monocyte adhesion and chemotaxis by directly targeting adhesion molecules and chemokine receptors. The levels of miR-125a are influenced by the type of inflammatory stimulus, which in turn strongly impacts the phenotype of human monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Miguel Camba-Gomez, Laura Arosa, Oreste Gualillo, Javier Conde-Aranda
Summary: Despite the benefits of current therapeutic options, there is a need for novel pharmacological targets to improve the treatment of inflammatory bowel disease (IBD). Chemokine and chemokine receptors have emerged as appealing options, as they regulate leukocyte trafficking and other processes related to intestinal inflammation development.
DRUG DISCOVERY TODAY
(2022)