期刊
JOURNAL OF CELL SCIENCE
卷 126, 期 15, 页码 3475-3484出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.129700
关键词
Integrins; Macrophage; Migration
类别
资金
- Spanish Ministerio de Ciencia y Tecnologia [BFU2010-16669, CSD-2007-00008]
- Wellcome Trust [090899/Z/09/Z]
- DFG [SFB 446]
- EMBO
- Spanish Ministerio de Ciencia y Tecnologia
- MRC
- Wellcome Trust [090899/Z/09/Z] Funding Source: Wellcome Trust
Throughout embryonic development, macrophages not only act as the first line of defence against infection but also help to sculpt organs and tissues of the embryo by removing dead cells and secreting extracellular matrix components. Key to their function is the ability of embryonic macrophages to migrate and disperse throughout the embryo. Despite these important developmental functions, little is known about the molecular mechanisms underlying embryonic macrophage migration in vivo. Integrins are key regulators of many of the adult macrophage responses, but their role in embryonic macrophages remains poorly characterized. Here, we have used Drosophila macrophages (haemocytes) as a model system to address the role of integrins during embryonic macrophage dispersal in vivo. We show that the main beta PS integrin, myospheroid, affects haemocyte migration in two ways; by shaping the three-dimensional environment in which haemocytes migrate and by regulating the migration of haemocytes themselves. Live imaging revealed a requirement for myospheroid within haemocytes to coordinate the microtubule and actin dynamics, and to enable haemocyte developmental dispersal, contact repulsion and inflammatory migration towards wounds.
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