Article
Environmental Sciences
Huanhuan Wang, Yao Chen, Xudan Liu, Ruo Zhang, Xiaotong Wang, Qianhui Zhang, Yuting Wei, Fang Fang, Ye Yuan, Qianqian Zhou, Yinqiao Dong, Sainan Shi, Xiaojing Jiang, Xin Li
Summary: This study investigated the mechanisms of microglia activation and TNF-alpha production induced by arsenic in the nervous system. It was found that microglia-derived TNF-alpha induced necroptosis in neuronal cells, suggesting its role in arsenic-related neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Jianxin Qiu, Xiaohang Zheng, Guoping Cai, Jiajing Ye, Ting Jiang, Lihua Chen, Ze Li, Yuhang Gong, Zhenghua Hong, Haixiao Chen
Summary: This study provides evidence supporting the potential role of AZD8330 in the management of osteoarthritis by attenuating inflammation and regulating the NF-kappa B/P65 signaling pathway to alleviate chondrocyte degradation. The findings from animal experiments and in vitro cell experiments support this conclusion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Wang, Changhua Hu, Yu Zhao, Xiaoquan Hu
Summary: In this study, a novel Smac mimetic, ASTX660, was shown to induce necroptosis in apoptosis-insensitive bladder cancer (BC) cells. Mechanistically, ASTX660 promoted the formation of the necrosome complex, and its efficacy was dependent on TNF-alpha signaling and IRF1 after caspase inhibition. These findings suggest that ASTX660 can overcome the limitation of apoptosis induction and provide important clues for the design of a novel treatment strategy for BC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Hang Liu, Xueyan Dai, Shiwen Xu, Huiling Guo, Jiamei Zhu, Sunan Wang, Yuning Wu, Caiying Zhang
Summary: This study investigated the effects of molybdenum (Mo) and cadmium (Cd) on myocardium injury in ducks and the function of NF-κB/TNF-α axis. The findings showed that the accumulation of Mo and/or Cd caused elements imbalance and necroptosis in myocardial tissue. Mo and/or Cd induced necroptosis via the NF-κB/TNF-α axis and decreased death receptor-mediated apoptosis in duck myocardium, with different effects on mitochondrial-mediated apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao, Xin Lin
Summary: The phosphorylation of RIPK1 at tyrosine residue is crucial for regulating cell death and inflammation, and its dysregulation can lead to systemic inflammation and disturbed hematopoiesis.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Francesca Pinci, Moritz M. Gaidt, Christophe Jung, Dennis Nagl, Gunnar Kuut, Veit Hornung
Summary: The process of necroptosis leads to the release of soluble TNF, which not only promotes TNF translation but also enhances its release by activating ADAM proteases. This shedding response, associated with lytic cell death, triggers TNF release in a switch-like manner that exceeds steady-state TNF processing in magnitude and speed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Rajendra Karki, Thirumala-Devi Kanneganti
Summary: The innate immune system plays a crucial role in the development of COVID-19, but dysregulated immune responses can lead to detrimental inflammation. Therefore, careful regulation of the innate immune system is essential for infection control.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Xiaoyu Fan, Xin Xu, Xinjie Wu, Runzhi Xia, Fuqiang Gao, Qingyu Zhang, Wei Sun
Summary: In this study, a TNF-alpha-induced ONFH model in human BMECs was established in vitro, and the AptTNF-alpha was shown to protect BMECs from necroptosis by inhibiting the RIP1/RIP3/MLKL signaling pathway.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Health Care Sciences & Services
Hung-Jen Shih, Chao-Yuan Chang, Milton Chiang, Van Long Le, Hao-Jen Hsu, Chun-Jen Huang
Summary: The novel peptide KCF18 can simultaneously inhibit TNF-alpha, IL-1 beta, and IL-6, leading to significantly lower levels of liver injury in mice with endotoxemia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Immunology
Tiziano A. Schweizer, Srikanth Mairpady Shambat, Clement Vulin, Sylvia Hoeller, Claudio Acevedo, Markus Huemer, Alejandro Gomez-Mejia, Chun-Chi Chang, Jeruscha Baum, Sanne Hertegonne, Eva Hitz, Thomas C. Scheier, Daniel A. Hofmaenner, Philipp K. Buehler, Holger Moch, Reto A. Schuepbach, Silvio D. Brugger, Annelies S. Zinkernagel
Summary: The study found that in severely ill COVID-19 patients, neutrophils exhibit a necroptosis-sensitive phenotype, characterized by cell lysis, increased release of DAMPs, elevated RIPK1 levels, and involvement of MLKL. This necroptosis is induced by the TNFRI/TNF-alpha axis. Furthermore, reduced sFasL levels in COVID-19 patients directly increase RIPK1 levels, exacerbate TNF-induced necroptosis, and correlate with disease severity, which is abolished in patients treated with glucocorticoids.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Immunology
Andre C. Ferreira, Carolina Q. Sacramento, Filipe S. Pereira-Dutra, Natalia Fintelman-Rodrigues, Priscila P. Silva, Mayara Mattos, Caroline S. de Freitas, Andressa Marttorelli, Gabrielle R. de Melo, Mariana M. Campos, Isaclaudia G. Azevedo-Quintanilha, Aluana S. Carlos, Joao Vitor Emidio, Cristiana C. Garcia, Patricia T. Bozza, Fernando A. Bozza, Thiago M. L. Souza
Summary: This study found that influenza virus infection can induce inflammatory programmed cell death in macrophages, and inhibiting inflammatory cell death can reduce inflammation and lung injury. This study identified an additional mechanism involved in severe influenza and proposed a clinically available method for treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ru He, Zhengfeng Wang, Shi Dong, Zhou Chen, Wence Zhou
Summary: This article introduces the role and molecular mechanisms of necroptosis in pancreatic diseases and explores its potential as a new therapeutic target.
Article
Biochemistry & Molecular Biology
Yongjun Hu, Hongwei Pan, Jianqiang Peng, Jin He, Mingxiang Tang, Sulan Yan, Jingjing Rong, Junshan Li, Zhaofen Zheng, Haijun Wang, Yanfu Liu, Xin Zhong
Summary: The study showed that RES attenuates cell necroptosis induced by myocardial hypoxia/reoxygenation injury by inhibiting the TNF-α/RIP1/RIP3/MLKL signaling pathway, leading to increased cell viability and decreased necroptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Multidisciplinary Sciences
Marie-Anais Locquet, Gabriel Ichim, Joseph Bisaccial, Aurelie Dutour, Serge Lebeque, Marie Castets, Kathrin Weber
Summary: In cancer cells, activation of TLR3 without Caspase-8 can trigger a new form of cell death that is distinct from classical apoptosis. This type of cell death is associated with lysosomal permeabilization, which occurs upstream of caspase activation and represents a default death mechanism in the absence of Caspase-8.
SCIENTIFIC REPORTS
(2021)