Review
Chemistry, Medicinal
Motahareh Boozari, Hossein Hosseinzadeh
Summary: This paper provides an updated and comprehensive review of the molecular mechanisms of crocin, a hydrophilic carotenoid synthesized in the flowers of the Crocus genus. The biological and pharmacological properties of crocin, including its memory-enhancing, anxiolytic, aphrodisiac, antidepressant, and neuroprotective effects, are discussed. Various studies have confirmed the significant impact of crocin on controlling pathological conditions such as oxidative stress, inflammation, metabolic disorders, neurodegenerative disorders, and cancer. The regulatory effects of crocin on multiple signaling pathways, particularly the PI3K/AKT/mTOR pathway, play a crucial role in these effects.
PHYTOTHERAPY RESEARCH
(2022)
Review
Microbiology
Hokuto Ohtsuka, Kazuki Imada, Takafumi Shimasaki, Hirofumi Aiba
Summary: The fission yeast S. pombe adapts to the environment and survives in nutrient-starved conditions through sexual differentiation and extension of the chronological lifespan. Spore formation in S. pombe is highly resistant to stresses and spores can survive for a long period. This minireview focuses on the molecular mechanisms of spore formation induced by starvation and highlights the presence of an effective survival mechanism.
Article
Cell Biology
Ian G. Ganley, Anne Simonsen
Summary: Mitochondria are crucial for cellular processes and are targeted for degradation through autophagy, but the mechanisms and importance of this process are not well understood.
JOURNAL OF CELL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Hong Li, Yangyang Zhou, Xinyan Qin, Jing Peng, Run Han, Yang Lv, Cong Li, Lijuan Qi, Gao- Ping Qu, Li Yang, Yanjie Li, William Terzaghi, Zhen Li, Feng Qin, Zhizhong Gong, Xing Wang Deng, Jigang Li
Summary: Abscisic acid (ABA) is an important plant hormone for adapting to environmental stresses. This study established a complete ABA signaling pathway in yeast cells and analyzed the role of light signaling components. The results showed that photoactivated photoreceptors attenuate ABA signaling by interacting with key components of the ABA signaling module, enhancing ABA tolerance in light-grown plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Yalu Zhang, Qiaofei Liu, Sen Yang, Quan Liao
Summary: CD58 glycoprotein is a costimulatory receptor widely distributed on human tissue cells, which interacts with its ligand CD2 to activate and proliferate T/NK cells, as well as promote cell adhesion and recognition. Soluble CD58 plays a crucial role in immunosuppression and tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shunqi Wang, Yingxing Wang, Suqi Zou
Summary: This article reviews the process of oligodendrocyte myelination and its regulatory factors, including proliferation, differentiation, and factors influencing myelination.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Sreedhar Nellaepalli, Anne Sophie Lau, R. Paul Jarvis
Summary: Chloroplasts play a crucial role in photosynthesis and other metabolic and signaling processes for plant growth and development. This article presents the mechanistic details of protein import and the regulation of chloroplast proteins by the ubiquitin-proteasome system (UPS).
JOURNAL OF CELL SCIENCE
(2023)
Article
Cell Biology
Sreedhar Nellaepalli, Anne Sophie Lau, R. Paul Jarvis
Summary: Chloroplasts are important organelles for photosynthesis and various metabolic and signaling processes. Most chloroplast proteins are encoded by the nucleus and need to be imported from the cytosol. The protein import machinery and the ubiquitin-proteasome system play crucial roles in regulating chloroplast biogenesis and protein homeostasis.
JOURNAL OF CELL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Tomas Grousl, Jana Vojtova, Jiri Hasek, Tomas Vomastek
Summary: Stress granules (SGs) are membrane-less organelles composed mainly of messenger ribonucleoproteins, formed as a result of cell's conserved evolutionary strategy to stress. They sequester translationally inactive mRNA molecules during periods of robust environmental stress, allowing preferential translation of stress response transcripts. SGs play a role in cellular reprogramming under stress conditions and viral infection, affecting mRNA translation specificity, localization, and stability. Studies in yeast have provided valuable insights into SG biology, despite specific differences between yeast and mammalian SGs. This review summarizes data on SGs formation under different stress conditions in Saccharomyces cerevisiae and other yeast species.
Article
Multidisciplinary Sciences
Vedrana Andric, Alicia Nevers, Ditipriya Hazra, Sylvie Auxilien, Alexandra Menant, Marc Graille, Benoit Palancade, Mathieu Rougemaille
Summary: In fission yeast, the uncharacterized lncRNA mamRNA plays a central role in shaping the meiotic gene expression program by scaffolding the antagonistic RNA-binding proteins Mmi1 and Mei2 to ensure their reciprocal inhibition during mitotic growth.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Daqiang Wu, Yongkang Chu, Wenfan Wei, Ling Liu, Chuanhai Fu
Summary: This study used live-cell microscopy and an algorithm to quantitatively assess the mixing of parental mitochondria in fission yeast. The results showed that parental mitochondria mixed progressively during meiosis. The study also identified mitochondrial fission and the size of the conjugation neck as limiting factors in restricting mitochondrial mixing.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Review
Environmental Sciences
Monica Lopes-Ferreira, Luiz Rogerio Ludwig Farinha, Yasmin Stefanie Oliveira Costa, Felipe Justiniano Pinto, Geonildo Rodrigo Disner, Joao Gabriel dos Santos da Rosa, Carla Lima
Summary: The increasing concern over the risks of pesticide exposure, particularly due to their unintended effects on non-target organisms, has highlighted the importance of proper handling and regulation of these substances. Pesticides have been found to induce inflammation in different experimental models, emphasizing the need for research into safer and sustainable practices to reduce reliance on synthetic pesticides and fertilizers.
Article
Biochemistry & Molecular Biology
Ikumi Fujita, Akatsuki Kimura, Akira Yamashita
Summary: In this study, it was found that fission yeast undergoes premeiotic nuclear oscillation, which is dependent on microtubules and is driven by cytoplasmic dynein. The oscillation frequency is cell length-dependent and is controlled by a balance between microtubule and viscous drag forces, as well as microtubule dynamics. These findings provide a basis for understanding the physical properties of microtubule-dependent nuclear movements.
Review
Cell Biology
Bahare Shokouhian, Hamidreza Aboulkheyr Es, Babak Negahdari, Atena Tamimi, Maryam Shahdoust, Anastasia Shpichka, Peter Timashev, Moustapha Hassan, Massoud Vosough
Summary: Development is a complex process involving cell differentiation, and understanding the similarities in gene expression profiles between malignant and undifferentiated cells is crucial. Hepatocellular carcinoma (HCC) is a prevalent cancer with limited treatment options, and targeting common signaling pathways in liver development and HCC could provide a rational therapeutic approach.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, Research & Experimental
Qingqing Xie, Jiejuan Cheng, Wuxuan Mei, Dexing Yang, Pengfei Zhang, Changchun Zeng
Summary: This article explores the formation mechanisms of biomolecular condensates (BMCs) and their biophysical properties, as well as the role of liquid-liquid phase separation (LLPS) in tumorigenesis. Understanding LLPS is crucial for developing effective antitumor therapeutic strategies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yoko Otsubo, Tomohiko Matsuo, Akiko Nishimura, Masayuki Yamamoto, Akira Yamashita
Article
Biology
Yuichi Shichino, Yoko Otsubo, Yoshitaka Kimori, Masayuki Yamamoto, Akira Yamashita
Article
Cell Biology
Yukiko Nakase, Mai Nakase, Jun Kashiwazaki, Tomoka Murai, Yoko Otsubo, Issei Mabuchi, Masayuki Yamamoto, Kaoru Takegawa, Tomohiro Matsumoto
JOURNAL OF CELL SCIENCE
(2013)
Article
Cell Biology
Yoko Otsubo, Akira Yamashita, Hayao Ohno, Masayuki Yamamoto
JOURNAL OF CELL SCIENCE
(2014)
Article
Physics, Applied
Shinji Yoshimura, Mitsutoshi Aramaki, Yoko Otsubo, Akira Yamashita, Kazunori Koga
JAPANESE JOURNAL OF APPLIED PHYSICS
(2019)
Article
Genetics & Heredity
Yuichi Shichino, Yoko Otsubo, Masayuki Yamamoto, Akira Yamashita
Review
Genetics & Heredity
Yoko Otsubo, Yoshiaki Kamada, Akira Yamashita
Article
Biochemistry & Molecular Biology
Maho Yagi-Utsumi, Tomohiro Tanaka, Yoko Otsubo, Akira Yamashita, Shinji Yoshimura, Motohiro Nishida, Koichi Kato
Summary: The study reveals that cold atmospheric plasma can affect the amyloidogenic protein Aβ associated with Alzheimer's disease by selectively oxidizing certain amino acid residues, inhibiting its fibril formation. This provides insights into potential novel applications of CAP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Hokuto Ohtsuka, Mikuto Kobayashi, Takafumi Shimasaki, Teppei Sato, Genki Akanuma, Yasuyuki Kitaura, Yoko Otsubo, Akira Yamashita, Hirofumi Aiba
Summary: This study demonstrates that magnesium depletion extends the lifespan of yeast through the Ecl1 gene family and the general amino acid control pathway. The Ecl1 family genes regulate ribosome amount and contribute to longevity by activating the evolutionarily conserved GAAC pathway.
Article
Physics, Applied
Shinji Yoshimura, Yoko Otsubo, Akira Yamashita, Katsuki Johzuka, Takayoshi Tsutsumi, Kenji Ishikawa, Masaru Hori
Summary: The characteristics of a gas-temperature-controllable atmospheric-pressure helium plasma jet and the development of an experimental system for cell viability assays of yeasts are described. The physicochemical properties of the plasma plume were similar to those of a typical helium plasma jet and allowed for maintaining a temperature suitable for yeast. The experimental system showed good reproducibility of cell viability and can be used for various experiments, including the identification of genes involved in resistance to direct plasma irradiation.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Cell Biology
Hokuto Ohtsuka, Hiroki Sakata, Yuto Kitazaki, Masanobu Tada, Takafumi Shimasaki, Yoko Otsubo, Yasukichi Maekawa, Mikuto Kobayashi, Kazuki Imada, Akira Yamashita, Hirofumi Aiba
Summary: In Schizosaccharomyces pombe, the ecl family genes are induced by various signals including nutrient starvation and environmental stress. The induction of these genes is important for cell viability and sexual differentiation. This study identifies phosphate starvation as a specific condition that induces the ecl3+ gene, providing insights into the regulation of these genes and their contribution to cellular responses and starvation adaptations.
JOURNAL OF CELL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Hokuto Ohtsuka, Yoko Otsubo, Takafumi Shimasaki, Akira Yamashita, Hirofumi Aiba
Summary: The ecl family genes in Schizosaccharomyces pombe are positive regulators of chronological lifespan and involved in various biological processes such as nutritional starvation and stress resistance.
MOLECULAR MICROBIOLOGY
(2023)
Review
Physics, Applied
Shinji Yoshimura, Yoko Otsubo, Akira Yamashita, Kenji Ishikawa
Summary: This review highlights the importance of gas temperature control in nonequilibrium atmospheric pressure plasmas for direct plasma treatments of living organisms. It discusses critical parameters associated with these treatments and assesses the current status and prospects for further developments in understanding the interactions between plasma and living organisms, emphasizing the significance of normothermic plasma treatment.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Yoko Otsubo, Akio Nakashima, Masayuki Yamamoto, Akira Yamashita
