Article
Oncology
Matthew L. Fisher, Seamus Balinth, Yon Hwangbo, Caizhi Wu, Carlos Ballon, John E. Wilkinson, Gary L. Goldberg, Alea A. Mills
Summary: BRD4 plays a critical role in the regulation of cancer stem-like properties and is highly elevated in the aggressive subpopulation of cells in squamous cell carcinomas. Targeting BRD4 can effectively inhibit Delta Np63 alpha, reducing spheroid formation and inhibiting tumor growth.
Article
Biochemistry & Molecular Biology
Yu Yamamoto, Osamu Miura, Takashi Ohyama
Summary: The study reveals that cruciform structures present in the Pou5f1 enhancer in mice play a crucial role in maintaining the integrity of ES cells and regulating the transcription of key genes involved in pluripotency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hongjian Zhao, Junjun Huang, Ming Chen, Baoru Li, Xinran Chen, Mingqing Zhou
Summary: TRIM6 promotes migration and invasion of colorectal cancer cells, potentially acting as an upstream regulatory factor for signal transducer and activator of transcription 3 (STAT3) and could be a potential therapeutic target for CRC metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Xiaoguang Li, Tongkai Li, Chunhe Li, Tiejun Li
Summary: Understanding complex gene regulatory networks is a fundamental task in systems biology, and reducing the degrees of freedom and identifying main biological pathways is key. This paper applied transition path theory (TPT) and Markov state modeling (MSM) to study two cell fate decision processes, revealing important factors in determining cell fates and identifying transition rates. The results provided detailed insights into biological processes and can be applied to studying other biological systems.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens
Summary: The study demonstrates that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, regulating its stability and the abundance of a subset of SCFFBW7 substrates, with concomitant FBW7 inactivation rescuing the effects of TRIP12 deficiency.
NATURE COMMUNICATIONS
(2021)
Article
Biology
H. Nayanga Thirmanne, Feinan Wu, Derek H. Janssens, Jherek Swanger, Ahmed Diab, Heather M. Feldman, Robert A. Amezquita, Raphael Gottardo, Patrick J. Paddison, Steven Henikoff, Bruce E. Clurman
Summary: The study investigated the effects of misregulated Fbw7 substrates on colorectal cancer cells using RNA-Seq and high-resolution mapping techniques. The findings revealed widespread transcriptional changes and altered transcription factor occupancy caused by Fbw7 mutations. Additionally, Fbw7 loss was associated with increased expression of MHC Class II genes such as CIITA.
Article
Biochemistry & Molecular Biology
Rene Winkler, Ann-Sophie Magdefrau, Eva-Maria Piskor, Markus Kleemann, Mandy Beyer, Kevin Linke, Lisa Hansen, Anna-Maria Schaffer, Marina E. Hoffmann, Simon Poepsel, Florian Heyd, Petra Beli, Tarik Moroy, Siavosh Mahboobi, Oliver H. Kramer, Christian Kosan
Summary: This study found that inhibition of histone deacetylase 6 (HDAC6) reduces the levels of oncogenic MYC and prevents the development of MYC-induced aggressive B-cell lymphoma in a mouse model. The HDAC6 inhibitor alters protein-protein interactions and acetylation state of certain substrates, such as tubulin, leading to impaired nuclear import and increased degradation of MYC. Importantly, the inhibitor specifically targets cancer cells with high levels of MYC without affecting non-tumor cells. These findings highlight the potential of HDAC6 inhibition as a therapeutic strategy for MYC-dependent B-cell lymphoma.
Review
Oncology
Xin Wan, Wei Guo, Zhumei Zhan, Ou Bai
Summary: This review focuses on the functions, substrates, and expression of FBW7 in malignant lymphoproliferative disorders. FBW7, as a key component of UPS proteins and a critical tumor suppressor, plays an important role in controlling protein degradation and the development of various cancers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Puja Agrawal, Sridhar Rao
Summary: Cell fate decisions rely on gene expression changes mediated by regulatory elements like enhancers and CTCF binding sites. These elements play crucial roles in early mammalian development and impact cell-type specific gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo, Tianhui Gao
Summary: This study confirmed a new mechanism related to miR-4721 in NPC tumorigenesis, revealing a negative feedback loop between miR-4721, FOXA1, and Nanog that activates downstream regulators of stem cell signaling to promote enrichment and metastasis of NPC stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dhananjaya Pal, Kendra R. Vann, Shweta Joshi, Namood E. Sahar, Guillermo A. Morales, Dalia El-Gamal, Tatiana G. Kutateladze, Donald L. Durden
Summary: The study developed a first-in-class inhibitor SRX3262 that simultaneously blocks three driver pathways of MCL and overcomes resistance. The inhibitor destabilizes c-MYC, induces apoptosis, providing a new approach to treat MCL.
Article
Oncology
Delong Yin, Xiaohui Zhang, Qinying Jiang, Shuai Luo, Yang Luo, Peng Cheng, Guoqing Jin, Changyu Liu
Summary: This study demonstrates that overexpression of Nanog can enhance the proliferative ability of EpSCs and promote wound healing. It also suggests that Nanog regulates the expression levels of c-Myc and p53. These findings support the use of Nanog in scald treatment and provide insights into the underlying molecular mechanism.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Multidisciplinary Sciences
Margot Jarrige, Helene Polveche, Alexandre Carteron, Stephane Janczarski, Marc Peschanski, Didier Auboeuf, Cecile Martinat
Summary: Human pluripotent stem cells have brought forth a new era in disease modeling, drug discovery, and cell therapy development. SISTEMA, a curated gene expression database, serves as a one-stop resource for the stem cell community to easily evaluate gene expression levels and compare them across different conditions.
Article
Biochemistry & Molecular Biology
Daniel B. Grabarczyk, Olga A. Petrova, Luiza Deszcz, Robert Kurzbauer, Paul Murphy, Juraj Ahel, Antonia Vogel, Rebeca Gogova, Victoria Faas, Darja Kordic, Alexander Schleiffer, Anton Meinhart, Richard Imre, Anita Lehner, Jana Neuhold, Gerd Bader, Peggy Stolt-Bergner, Jark Boettcher, Bernhard Wolkerstorfer, Gerhard Fischer, Irina Grishkovskaya, David Haselbach, Dirk Kessler, Tim Clausen
Summary: HUWE1 is a universal quality-control E3 ligase, whose crystal structure reveals its specificity for marking diverse, unrelated substrates. It adopts a unique snake-like structure, with a highly dynamic ring structure facilitating interaction with various protein targets.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Oncology
Radhakrishnan Vishnubalaji, Hibah Shaath, Monther Al-Alwan, Essam M. Abdelalim, Nehad M. Alajez
Summary: This review discusses the interaction between miRNAs and pluripotency transcription factors and their importance in the acquisition of cancer stem cell features, tumor heterogeneity, and resistance to cancer therapies. It also explores the potential of interfering with miRNA-TF networks to enhance tumor cell responsiveness to treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Eri Sugawara, Masaru Kato, Yuki Kudo, Wenshi Lee, Ryo Hisada, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Tomohiro Onodera, Shigetsugu Hatakeyama, Tatsuya Atsumi
Article
Multidisciplinary Sciences
Hidehisa Takahashi, Amol Ranjan, Shiyuan Chen, Hidefumi Suzuki, Mio Shibata, Tomonori Hirose, Hiroko Hirose, Kazunori Sasaki, Ryota Abe, Kai Chen, Yanfeng He, Ying Zhang, Ichigaku Takigawa, Tadasuke Tsukiyama, Masashi Watanabe, Satoshi Fujii, Midori Iida, Junichi Yamamoto, Yuki Yamaguchi, Yutaka Suzuki, Masaki Matsumoto, Keiichi Nakayama, Michael P. Washburn, Anita Saraf, Laurence Florens, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway, Shigetsugu Hatakeyama
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Erika Sugisawa, Yasunori Takayama, Naoki Takemura, Takeshi Kondo, Shigetsugu Hatakeyama, Yutaro Kumagai, Masataka Sunagawa, Makoto Tominaga, Kenta Maruyama
Article
Multidisciplinary Sciences
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
NATURE COMMUNICATIONS
(2020)
Article
Biology
Masashi Watanabe, Yasushi Saeki, Hidehisa Takahashi, Fumiaki Ohtake, Yukiko Yoshida, Yusuke Kasuga, Takeshi Kondo, Hiroaki Yaguchi, Masanobu Suzuki, Hiroki Ishida, Keiji Tanaka, Shigetsugu Hatakeyama
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Tadasuke Tsukiyama, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Summary: Wnt signaling pathway plays crucial roles in various stages of life, regulating morphogenesis in embryo development and tissue homeostasis in adults. Regulation of Wnt signaling occurs at multiple levels, including on receptors, beta-catenin protein, and through transcriptional regulation. Recent studies have focused on Wnt receptor regulation mechanisms, particularly targeting RNF43 and ZNRF3, mutated genes associated with cancer, with ongoing discoveries and unanswered questions.
Article
Immunology
Akira Nakazono, Yuji Nakamaru, Mahnaz Ramezanpour, Takeshi Kondo, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Aya Honma, P. J. Wormald, Sarah Vreugde, Masanobu Suzuki, Akihiro Homma
Summary: SARS-CoV-2 cell entry in the nasal mucosa is promoted by the activation of innate immune signals via TLR3, but this expression is suppressed in the presence of the corticosteroid fluticasone propionate (FP). Further studies are needed to determine whether FP can suppress SARS-CoV-2 viral cell entry.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Allergy
Masanobu Suzuki, Takayoshi Suzuki, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Akira Nakazono, Aya Honma, Yuji Nakamaru, Sarah Vreugde, Akihiro Homma
Summary: Zinc plays a crucial role in maintaining immune system function, and decreased zinc levels may lead to various inflammatory diseases. There is a potential vicious cycle between zinc deficiency and inflammatory conditions, highlighting the importance of maintaining adequate zinc levels for overall health and immunity.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Dermatology
Keiko Tokuchi, Shinya Kitamura, Takuya Maeda, Masashi Watanabe, Shigetsugu Hatakeyama, Satoshi Kano, Shinya Tanaka, Hideyuki Ujiie, Teruki Yanagi
Summary: The study revealed that the expression of FAM83H is lower in cutaneous squamous cell carcinoma compared to normal epidermis, and is associated with differentiation grade. FAM83H plays a critical role in regulating keratin distribution and cell migration/invasion in SCC.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ayano Inoue, Masashi Watanabe, Takeshi Kondo, Satoshi Hirano, Shigetsugu Hatakeyama
Summary: There has been a remarkable breakthrough in cancer treatment, particularly in the field of checkpoint blockade immunotherapy. Recent studies have shown that TRIM22 negatively regulates MHC-II expression and inhibiting TRIM22 can increase MHC-II expression in cancer cells, which may provide a therapeutic target to enhance immunotherapy effectiveness.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yusuke Kasuga, Ryota Ouda, Masashi Watanabe, Xin Sun, Miki Kimura, Shigetsugu Hatakeyama, Koichi S. Kobayashi
Summary: Major histocompatibility complex (MHC) class I and II molecules are critical for adaptive immunity. The protein FBXO11 has been identified as an E3 ligase that regulates CIITA protein level through ubiquitination-mediated degradation, thus determining the level of MHC-II.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Otorhinolaryngology
Shogo Kimura, Masanobu Suzuki, Yuji Nakamaru, Satoshi Kano, Masashi Watanabe, Aya Honma, Akira Nakazono, Nayuta Tsushima, Shigetsugu Hatakeyama, Akihiro Homma
Summary: This study found that high expression of TRIM27 in sinonasal mucosal melanoma (SNMM) is associated with advanced disease, poor prognosis, and distant metastasis, suggesting that TRIM27 may serve as a novel biomarker for prognosis in SNMM.
Meeting Abstract
Oncology
Tadasuke Tsukiyama, Tohru Ishitani, Shigetsugu Hatakeyama
Article
Oncology
Shanshan Liang, Hidehisa Takahashi, Tetsuro Hirose, Yasuhiro Kuramitsu, Shigetsugu Hatakeyama, Hironori Yoshiyama, Ruoyu Wang, Jun-Ichi Hamada, Hisashi Iizasa
CANCER GENOMICS & PROTEOMICS
(2020)
Meeting Abstract
Oncology
Tadasuke Tsukiyama, Tohru Ishitani, Shigetsugu Hatakeyama
