期刊
JOURNAL OF CELL SCIENCE
卷 126, 期 1, 页码 274-288出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.115188
关键词
Sirtuin-3; Mitochondria; Hexokinase-2; Bak; Bax; Apoptosis; Cisplatin
类别
资金
- National Institutes of Health [5R01CA118356, 5R01AA01287]
- NATIONAL CANCER INSTITUTE [R01CA118356] Funding Source: NIH RePORTER
Sirtuin-3 exhibits properties of a tumor suppressor partly emanating from its ability to control the state of mitochondrial metabolism, with depletion of sirt-3 increasing tumor cell survival. In the present study we demonstrate that depletion of sirtuin-3 brings about an anti-apoptotic phenotype via stimulating cyclophilin-D activity, which promotes the binding of hexokinase II to the mitochondria, thereby preventing Bak/Bax dependent mitochondrial injury and cell death. By contrast, increased expression of sirtuin-3 decreases cyclophilin-D activity, resulting in detachment of hexokinase II from the mitochondria and potentiation of Bak- and Bax-induced mitochondrial injury and loss of cell viability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据