期刊
JOURNAL OF CELL SCIENCE
卷 124, 期 6, 页码 865-872出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.076356
关键词
Actin; Intermediate filament; Micropattern; Migration; Nucleus
类别
资金
- Ministere de la Recherche
- Fondation pour la Recherche Medicale
- Uehara memorial foundation
- Institut Pasteur
- Agence Nationale pour la Recherche
- La Ligue contre le Cancer
The localization of the nucleus is precisely regulated, and defects in nuclear positioning are observed in diseases such as lissencephaly, cerebellar ataxia and dysplasia. We show here that cytoplasmic intermediate filaments are essential players in actin-dependent positioning of the nucleus. The actin retrograde flow is relayed by a flow of intermediate filaments that accumulate asymmetrically around the nuclear envelope. Perturbations of the intermediate filament network alter positioning of the nucleus in both migrating and immobile astrocytes. This function of intermediate filaments might be crucial for regulating cell motility, in particular in tumor cells expressing high levels of cytoplasmic intermediate filaments.
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