Review
Immunology
Maksim V. Baranov, Manoj Kumar, Stefano Sacanna, Shashi Thutupalli, Geert van den Bogaart
Summary: The size, shape, rigidity, and surface roughness of pathogens are important parameters affecting cellular uptake and immune responses, particularly in inflammasome activation and T cell activation. Understanding how the physical properties of particles influence immune responses can assist in the design of more effective vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Stephanie Levert, Julie Pilliod, Etienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frederic Calon, Nicole Leclerc
Summary: In this study, the interaction between Tau and FLNA proteins was explored, as well as the impact of FLNA on Tau pathology. The results showed that overexpression of FLNA led to the accumulation of Tau protein in cells, increased its phosphorylation and cleavage by Caspase-3, but did not increase its aggregation. Additionally, FLNA overexpression also induced the accumulation of annexin A2. However, in AD brains, the increase in FLNA did not correlate with Tau pathology.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, General & Internal
Lujia Feng, Haichun Li, Yong Du, Ting Zhang, Yingting Zhu, Zhidong Li, Ling Zhao, Xing Wang, Gongpei Wang, Linbin Zhou, Zhaorong Jiang, Zheng Liu, Zhancong Ou, Yuwen Wen, Yehong Zhuo
Summary: CCT5 protects against the effect of MERTK knockdown in human primary RPE cells and demonstrates the potential for effective treatment of MERTK-associated RP.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Affidah Sabran, Endang Kumolosasi, Ibrahim Jantan, Jamia Azdina Jamal, Norazrina Azmi, Malina Jasamai
Summary: The study found that selected phytoestrogens can induce apoptosis, cell cycle arrest, and phagocytosis in leukemia cells, while reducing the levels of ANXA1.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jianmin Chen, Lucy V. Norling, Jose Garrido Mesa, Marina De Paula Silva, Sophie E. Burton, Chris Reutelingsperger, Mauro Perretti, Dianne Cooper
Summary: Rheumatoid arthritis is associated with an increased risk of heart failure, leading to death. Treatment with hrAnxA1 can improve cardiac function in arthritic mice, slowing disease progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Gloria I. Perez, Matthew P. Bernard, Daniel Vocelle, Ahmed A. Zarea, Najla A. Saleh, Matthew A. Gagea, Doug Schneider, Maxine Bauzon, Terry Hermiston, Masamitsu Kanada
Summary: Under physiological conditions, PS predominantly localizes to the cytosolic leaflet of the plasma membrane. However, during apoptosis and in tumor cell-derived EVs, PS is exposed on the cell surface. This study demonstrates the importance of PS-exposing EVs as a potential biomarker for early cancer detection, and provides insights into different EV subtypes.
Article
Cell Biology
Yingyu Mao, Silvia C. Finnemann
Summary: The diurnal phagocytosis of spent photoreceptor outer segment fragments by retinal pigment epithelial cells is essential for visual function. Formation of phagocytic cups beneath surface-tethered POS requires the signaling of MerTK and activation of Rac1, with RhoA pathway inactivation playing a crucial role in the phagocytic process. Ultimately, manipulating RhoA pathway can restore phagocytic capacity to MerTK-deficient RPE.
Article
Biology
Daan Vorselen, Sarah R. Barger, Yifan Wang, Wei Cai, Julie A. Theriot, Nils C. Gauthier, Mira Krendel
Summary: The study reveals that during macrophage phagocytosis of antibody-opsonized targets, there is a prominent constriction driven by Arp2/3-mediated assembly of discrete actin protrusions. Contractile myosin-II activity contributes to late-stage phagocytic force generation and target ingestion. Observations of partial target eating attempts and sudden target release suggest that constriction may play a critical role in resolving complex in vivo target encounters.
Article
Pharmacology & Pharmacy
Masyitah Hasan, Endang Kumolosasi, Ibrahim Jantan, Malina Jasamai, Norlaili Nazarudin
Summary: Annexin A1 (ANXA1), an endogenous protein, plays important roles in the regulation of proliferation, cell cycle, phagocytosis, and apoptosis in leukemia cells. Knockdown of ANXA1 led to decreased expression and induced apoptosis in leukemia cells. It also affected the expression of caspases and Bcl-2, and enhanced phagocytosis activity. These findings suggest that ANXA1 knockdown might be a potential therapeutic strategy for leukemia.
ACTA PHARMACEUTICA
(2022)
Article
Oncology
Min-Chun Chuang, Jr-Hau Lung, Yi-Chuan Chen, Yu-Ching Lin, Ya-Chin Li, Ming-Szu Hung
Summary: The study revealed that ANXA1 plays critical roles in chemosensitivity to Osimertinib in lung cancer cells with EGFR mutations. Knockdown of ANXA1 increased chemosensitivity to Osimertinib and decreased tumorigenesis, invasion and migration of lung cancer cells with EGFR mutations. The research may have implications for the development of future lung cancer treatment strategies.
Review
Cell Biology
Thaise Goncalves Araujo, Sara Teixeira Soares Mota, Helen Soares Valenca Ferreira, Matheus Alves Ribeiro, Luiz Ricardo Goulart, Lara Vecchi
Summary: Annexin A1, initially known for its anti-inflammatory properties, has been found to switch to pro-inflammatory activity in the context of cancer. It exhibits pro-invasive and pro-tumoral effects in several cancers by inducing a favorable tumor microenvironment.
Review
Cell Biology
Filipe Resende, Simone de Araujo, Luciana Padua Tavares, Mauro Martins Teixeira, Vivian Vasconcelos Costa
Summary: Dysregulated inflammatory responses are associated with disease severity in viral infections. Annexin A1 (AnxA1) is a pro-resolving protein that regulates inflammation to control the severity of viral infections. However, viruses may hijack AnxA1 signaling to promote pathogen survival. This review provides an in-depth understanding of the role of AnxA1 in viral infections and discusses the therapeutic potential of AnxA1 and AnxA1 mimetics.
Article
Oncology
Piao Li, Lingling Li, Zhou Li, Shennan Wang, Ruichao Li, Weiheng Zhao, Yanqi Feng, Shanshan Huang, Lu Li, Hong Qiu, Shu Xia
Summary: The study found that the high expression of ANXA1 in bladder cancer is closely associated with disease progression and prognosis. Silencing ANXA1 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of bladder cancer cells, and suppresses the growth of xenografted bladder tumors. ANXA1 promotes the proliferation and migration of bladder cancer by activating the EGFR signaling pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Matthias H. Busch, Sjoerd A. M. E. G. Timmermans, Joop P. Aendekerk, Renee Ysermans, Jean Amiral, Jan G. M. C. Damoiseaux, Chris P. Reutelingsperger, Pieter van Paassen
Summary: Severe COVID-19 is characterized by hyperinflammation, vascular damage, and hypercoagulability. This study found that insufficient responses of Annexin A1 (AnxA1), a pro-resolving inhibitor, might contribute to the severe course of the disease. AnxA1 levels were significantly higher in moderate and severe COVID-19 cases compared to healthy controls, and elevated AnxA1 levels were associated with markers of inflammation and endothelial damage. AnxA1 was also higher in patients with thrombotic events and ICU admission. Baseline AnxA1 was identified as a predictor of thrombotic events, and the increase in AnxA1 over time was steeper in patients without adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Liang Wu, Changjie Liu, Dong-Yuan Chang, Rui Zhan, Jing Sun, Shi-He Cui, Sean Eddy, Viji Nair, Emily Tanner, Frank C. Brosius, Helen C. Looker, Robert G. Nelson, Matthias Kretzler, Jian-Cheng Wang, Ming Xu, Wenjun Ju, Ming-Hui Zhao, Min Chen, Lemin Zheng
Summary: The study revealed that ANXA1 levels were upregulated in kidneys of diabetic nephropathy patients, correlating with kidney function and outcomes. ANXA1 deficiency exacerbated kidney injuries, while ANXA1 overexpression ameliorated the disease. The ANXA1 mimetic peptide Ac2-26 showed therapeutic potential for diabetic nephropathy.
KIDNEY INTERNATIONAL
(2021)
Article
Physics, Multidisciplinary
L. Chen, S. Mankovsky, S. Wimmer, M. A. W. Schoen, H. S. Koerner, M. Kronseder, D. Schuh, D. Bougeard, H. Ebert, D. Weiss, C. H. Back
Article
Nanoscience & Nanotechnology
P. Faltermeier, G. V. Budkin, S. Hubmann, V. V. Bel'kov, L. E. Golub, E. L. Ivchenko, Z. Adamus, G. Karczewski, T. Wojtowicz, D. A. Kozlov, D. Weiss, S. D. Ganichev
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2018)
Article
Biochemistry & Molecular Biology
Michael D. Birnbaum, Ning Zhao, Balaji T. Moorthy, Devang M. Patel, Oleksandr N. Kryvenko, Laine Heidman, Akhilesh Kumar, William M. Morgan, Yuguang Ban, Isildinha M. Reis, Xi Chen, Mark L. Gonzalgo, Merce Jorda, Kerry L. Burnstein, Fangliang Zhang
Article
Physics, Applied
Tobias Preis, Christian Kick, Andreas Lex, Dieter Weiss, Jonathan Eroms, Akimitsu Narita, Yunbin Hu, Klaus Muellen, Kenji Watanabe, Takashi Taniguchi
APPLIED PHYSICS LETTERS
(2019)
Article
Biotechnology & Applied Microbiology
Akhilesh Kumar, Michael D. Birnbaum, Balaji T. Moorthy, Jayanti Singh, Anna Palovcak, Devang M. Patel, Fangliang Zhang
Review
Biochemistry & Molecular Biology
Devang M. Patel, Madhura Bose, Mark E. Cooper
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physics, Applied
Jimin Wang, Alexander Kurzendorfer, Lin Chen, Zhiwei Wang, Yoichi Ando, Yang Xu, Ireneusz Miotkowski, Yong P. Chen, Dieter Weiss
Summary: The study found that in a high-quality three-dimensional topological insulator film, carrier density can be independently tuned on top and bottom surfaces using gate electrodes, resulting in different conduction channels with varying mobility and density.
At low temperatures, conduction is dominated by Dirac surface states, leading to only two dominant conduction channels, while at high temperatures, a third channel emerges due to bulk effects, with different mobility and density characteristics.
APPLIED PHYSICS LETTERS
(2021)
Article
Physics, Applied
F. Eberle, D. Schuh, D. Bougeard, D. Weiss, M. Ciorga
Summary: In this study, we investigated the spin transport of in-plane spins in an array of narrow channels formed in a two-dimensional electron gas confined in an (In, Ga)As quantum well using the geometry of the spin field-effect transistor. We found a clear enhancement of the spin-diffusion length with decreasing channel width, up to 10 μm for the narrowest channels. Additionally, we observed a significantly higher spin signal when injecting into an array of narrow channels compared to injecting into a single narrow channel.
PHYSICAL REVIEW APPLIED
(2021)
Article
Multidisciplinary Sciences
Robin Huber, Max-Niklas Steffen, Martin Drienovsky, Andreas Sandner, Kenji Watanabe, Takashi Taniguchi, Daniela Pfannkuche, Dieter Weiss, Jonathan Eroms
Summary: In this study, band conductivity oscillations in a graphene superlattice were experimentally observed. These oscillations are governed by the internal structure of the Hofstadter butterfly (Brown-Zak oscillations) and a commensurability relation between the electron cyclotron radius and the superlattice period (Weiss oscillations). A complete description of the oscillations in two-dimensional superlattices was obtained, showing a detailed match between theory and experiment.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
S. Candussio, S. Bernreuter, T. Rockinger, K. Watanabe, T. Taniguchi, J. Eroms, I. A. Dmitriev, D. Weiss, S. D. Ganichev
Summary: This article reports on the observation of circular transversal terahertz photoconductivity in monolayer graphene supplied by a back gate. The photoconductivity response is caused by free carrier absorption and reverses its sign when the radiation helicity is switched. Additionally, the observation of a dc Hall effect suggests the breaking of time inversion symmetry induced by circularly polarized terahertz radiation in the absence of a magnetic field.
Article
Materials Science, Multidisciplinary
L. Chen, R. Islinger, J. Stigloher, M. M. Decker, M. Kronseder, D. Schuh, D. Bougeard, D. Weiss, C. H. Back
Summary: Current-induced spin-orbit torques in ferromagnet/nonmagnetic metal heterostructures provide possibilities for designing spintronic devices. We report a method to determine spin-orbit magnetic fields based on magnetization dynamics using time-resolved magneto-optic Kerr microscopy. Different mode patterns generated by SOFs and Oersted fields allow for measuring the SOFs in other material systems.
Article
Physics, Multidisciplinary
J. Ziegler, D. A. Kozlov, N. N. Mikhailov, S. Dvoretsky, D. Weiss
PHYSICAL REVIEW RESEARCH
(2020)
Article
Materials Science, Multidisciplinary
Tobias Voelkl, Denis Kochan, Thomas Ebnet, Sebastian Ringer, Daniel Schiermeier, Philipp Nagler, Tobias Korn, Christian Schueller, Jaroslav Fabian, Dieter Weiss, Jonathan Eroms
Article
Materials Science, Multidisciplinary
Sebastian Ringer, Stefan Hartl, Matthias Rosenauer, Tobias Voelkl, Maximilian Kadur, Franz Hopperdietzel, Dieter Weiss, Jonathan Eroms
Article
Materials Science, Multidisciplinary
J. Ziegler, R. Kozlovsky, C. Gorini, M. -H. Liu, S. Weishaupl, H. Maier, R. Fischer, D. A. Kozlov, Z. D. Kvon, N. Mikhailov, S. A. Dvoretsky, K. Richter, D. Weiss