Article
Chemistry, Multidisciplinary
Qingyun Yang, Yingxiao Gao, Xia Liu, Yihang Xiao, Mingxuan Wu
Summary: A new method for editing the N-tail of histone H3 using sortase mediated metathesis (SMM) is reported. This method expands the application scope of sortase and offers a strategy for precise editing of PTMs of cellular histone H3.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Virginia Lopez, Juan Ramon Tejedor, Antonella Carella, Maria G. Garcia, Pablo Santamarina-Ojeda, Raul F. Perez, Cristina Mangas, Rocio G. Urdinguio, Aitziber Aranburu, Daniel de la Nava, Maria D. Corte-Torres, Aurora Astudillo, Manuela Mollejo, Barbara Melendez, Agustin F. Fernandez, Mario F. Fraga
Summary: Epigenetic mechanisms, particularly involving the histone methyltransferase KMT5B and its mark H4K20me2, play a key role in glioblastoma multiforme (GBM). Downregulation of KMT5B is associated with DNA hypermethylation and loss of DNA hydroxymethylation in GBM samples. Ectopic overexpression of KMT5B induces tumor suppressor-like features and changes in gene expression, suggesting a possible role in GBM through epigenetic modulation of key target cancer genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Melody D. Fulton, Tran Dang, Tyler Brown, Y. George Zheng
Summary: This study explores how local changes on adjacent residues in histone substrate regulate the activities of PRMT1 and PRMT5 enzymes. Phosphorylation at H4S1 inhibits the activity of both enzymes, while the presence of a positively charged H4K5 is important for PRMT1 catalysis. Acetylation of H4K5 or loss of the H4K5 epsilon-amine affects the methylation of H4R3.
Article
Medicine, Research & Experimental
Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang
Summary: The study found that the gluconeogenic enzyme PCK1 promoted the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. SAM served as a methyl donor to support H3K9me3 modification, inhibiting the oncogene S100A11. This study reveals the potential therapeutic strategy of targeting the metabolic enzyme PCK1 and H3K9 trimethylation for hepatocellular carcinoma (HCC) treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo
Summary: This article describes the epigenetic changes that occur in the pathogen Mycobacterium tuberculosis and its host during infection, including DNA methylation, histone modification, and microRNA. It summarizes the research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat drug-resistant tuberculosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Endocrinology & Metabolism
Ye-Chi Cao, Su-Kang Shan, Bei Guo, Chang-Chun Li, Fu-Xing-Zi Li, Ming-Hui Zheng, Qiu-Shuang Xu, Yi Wang, Li-Min Lei, Ke-Xin Tang, Wen-Lu Ou-Yang, Jia-Yue Duan, Yun-Yun Wu, Muhammad Hasnain Ehsan Ullah, Zhi-Ang Zhou, Feng Xu, Xiao Lin, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Histone methylation modification may play a key role in the development of vascular calcification, which involves various complex pathophysiological processes. Comprehensive research on the role and mechanism of lysine methylation modification in VC is crucial for identifying new therapeutic targets and developing new drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Fei Xu, Wenhui Li, Xiao Yang, Lixin Na, Linjun Chen, Guobin Liu
Summary: Osteoporosis is a metabolic disease characterized by decreased bone mineral density and bone microstructure destruction. Epigenetics, including DNA methylation, histone modification, and non-coding RNAs, play an important role in post-transcriptional regulation and are closely related to bone metabolism processes such as osteogenic differentiation and bone remodeling. Abnormal epigenetic regulation can lead to bone metabolism-related diseases like osteoporosis, highlighting the importance of understanding epigenetic mechanisms for potential treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miriam R. B. Porzberg, Laust Moesgaard, Catrine Johansson, Udo Oppermann, Jacob Kongsted, Jasmin Mecinovic
Summary: This study examines the binding scope of asymmetric dimethylarginine mimics by Spindlin1 and finds that the biomolecular recognition is not significantly affected. High-energy water molecules play an important role in the reader-histone association.
Review
Oncology
Asad Mohammad, Sudhakar Jha
Summary: Epigenetic modifications, such as DNA methylation and histone modification, play a crucial role in cancer progression and metastasis. Inhibitors targeting deregulated enzymes can reverse these modifications and show promising results in cancer therapeutics.
Review
Immunology
Avinash Khadela, Vivek P. Chavda, Humzah Postwala, Yesha Shah, Priya Mistry, Vasso Apostolopoulos
Summary: Tuberculosis is a highly challenging and chronic infection that requires the action of the host's immune system. Epigenetic modification plays a crucial role in the pathophysiology and treatment of tuberculosis, but there are still gaps in the research.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)