期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 27, 期 2, 页码 285-292出版社
WILEY-BLACKWELL
DOI: 10.1111/nmo.12501
关键词
esophagus; high-resolution manometry; normal values; position
资金
- National Council for Scientific and Technological Development (CNPq)
- Medical Research Council [G0802313] Funding Source: researchfish
- MRC [G0802313] Funding Source: UKRI
Background Normal values of the esophageal motor function parameters for high-resolution manometry (HRM-EPT) adopted by the Chicago classification were established using the proprietary system of Given Imaging. It is conceivable that normal values of a system do not apply to data from others. Most studies using HRM were based on supine swallows, whereas deglutition occurs mostly in the upright position. We wished to establish normal values for HRM-EPT parameters obtained with the Sandhill's HRM-EPT system and compare the results in supine and sitting positions. Methods Sixty-nine healthy volunteers, 38 females, median age 27years, were included in this study. All underwent supine HRM, and 34 of them underwent sitting HRM, with at least 10 single 5-mL swallows for analysis obtained in each position. Key Results The normal range (5-95th percentiles) for the following parameters was calculated: distal contractile integral (DCI), 606-4998mmHgscm; contractile front velocity (CFV), 2.0-6.5cm/s; distal latency (DL), 5.1-8.8s; intrabolus pressure (IBP), 1.9-17.6 mmHg; upper esophageal sphincter (UES) pressure, 45.2-186.9mmHg; esophagogastric junction (EGJ) length, 1.8-4cm; EGJ resting pressure, 8.1-61.6mmHg, and integrated relaxation pressure (IRP) 2.5-23.5mmHg. Normal values of EGJ resting pressure, IRP, DCI, and IBP but not CFV, DL, and UES resting pressure were significantly lower in the sitting posture. Conclusions & Inferences Studies performed with Sandhill's HRM-EPT system should use its own specific normal data. Normal values should be established for different study
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