期刊
JOURNAL OF CELL BIOLOGY
卷 207, 期 1, 页码 13-21出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201407102
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资金
- National Institutes of Health [R37HD41900]
Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision.
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