Article
Biochemistry & Molecular Biology
Conor J. Sugden, Valentina Iorio, Lee D. Troughton, Ke Liu, Mychel R. P. T. Morais, Rachel Lennon, George Bou-Gharios, Kevin J. Hamill
Summary: Transgenic expression of LaNt alpha 31 in mice resulted in defects in tissue morphogenesis, including extravascular bleeding, kidney epithelial detachment, tubular dilation, disruption of the epidermal basal cell layer and hair follicle outer root sheath, as well as reduced cell numbers in the liver.
Article
Medicine, General & Internal
Yuanda Zhang, Qiao Zhang, Lihua Sun, Dongxu Zhao, Cijie Ruan, Jue Zhou, Haoyuan Tan, Yinghui Bao
Summary: The expression level of DCC receptor can better predict high intracranial pressure and prognosis than the level of serum Netrin-1 in severe traumatic brain injury.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xueli Xia, Zhenwei Mao, Wenxin Wang, Jie Ma, Jie Tian, Shengjun Wang, Kai Yin
Summary: Netrin-1 secreted by tumor cells activates the cAMP/PKA signaling pathway through interaction with A2BR on MDSCs, enhancing their immunosuppressive function. High levels of netrin-1 are correlated with MDSCs in colorectal cancer patients.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Madelen M. M. Diaz, Yanina Tsenkina, Dena Arizanovska, Patrick Mehlen, Daniel J. J. Liebl
Summary: The expression of the deleted in colorectal cancer (DCC) dependence receptor is upregulated in the traumatically injured brain, while the expression of its ligand netrin-1 is downregulated. Administration of netrin-1 can prevent oligodendrocyte cell death and improve motor function and myelin integrity after brain injury.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Multidisciplinary
Shiyi Bi, Wei Chen, Yanyun Fang, Yingfei Wang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu
Summary: Clustering of cell membrane receptors can regulate cell behaviors. This study presents a Raji cell Selective MAnipulation of Receptor Clustering (SMARC) strategy for CD20, which is driven by endogenous secretion of Raji cells. The strategy utilizes retractable DNA nanostrings anchored to the cell membrane CD20, which contract in response to Raji cell-secreted VEGF with corresponding CD20 clustering. The SMARC strategy selectively induces apoptosis in Raji cells with minimal interference to normal B cells, and shows promising in vivo therapeutic efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Sabrina Schlienger, Patricia T. Yam, Nursen Balekoglu, Hugo Ducuing, Jean-Francois Michaud, Shirin Makihara, Daniel K. Kramer, Baoyu Chen, Alfonso Fasano, Alfredo Berardelli, Fadi F. Hamdan, Guy A. Rouleau, Myriam Srour, Frederic Charron
Summary: Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. In this study, we identified ARHGEF7 as a candidate MM gene and demonstrated its role in Netrin-1-mediated axon guidance. We further showed that Arhgef7/Git1 acts as a multifunctional effector complex, activating Rac1 and Cdc42 and inhibiting Arf1 downstream of Netrin-1.
Article
Virology
Man Kuan, Hannah K. Jaeger, Onesmo B. Balemba, John M. O'Dowd, Deborah Duricka, Holger Hannemann, Emmerentia Marx, Natacha Teissier, Liliana Gabrielli, Maria Paola Bonasoni, Elizabeth M. Keithley, Elizabeth A. Fortunato
Summary: The study found that HCMV infection leads to the elimination of the developmentally important basement membrane protein nidogen 1 (NID1) from its host. The virus reduces transcription and induces degradation of the protein, impacting cell function.
JOURNAL OF VIROLOGY
(2021)
Article
Medicine, General & Internal
Jin-Ju Kim, Judith M. David, Sydney S. Wilbon, Javier Santos, Devang M. Patel, Anis Ahmad, Alla Mitrofanova, Xiaochen Liu, Shamroop K. Mallela, Gloria M. Ducasa, Mengyuan Ge, Alexis J. Sloan, Hassan Al-Ali, Marcia Boulina, Armando J. Mendez, Gabriel N. Contreras, Marco Prunotto, Anjum Sohail, Rafael Fridman, Jeffrey H. Miner, Sandra Merscher, Alessia Fornoni
Summary: DDR1 activation mediated by Col I induces CD36-mediated podocyte lipotoxic injury in Alport Syndrome mice. Ezetimibe interferes with the CD36/DDR1 interaction, thus protecting renal function. Targeting the Col I/DDR1 pathway may represent a new therapeutic strategy for patients with AS and CKD associated with Col4 mutations.
Article
Cell Biology
Julian Eschenbruch, Georg Dreissen, Ronald Springer, Jens Konrad, Rudolf Merkel, Bernd Hoffmann, Erik Noetzel
Summary: The study reveals that actin microspikes are used as functional precursors for filopodia to initiate basement membrane penetration and widen collagen IV pores to anchor within the membrane scaffold via force-transmitting focal adhesions. Pre-invasive basal cells exhibit predominantly cortical actin networks and actin microspikes, which convert into highly contractile stress fibers in response to pro-invasive conditions. Ultimately, these EMT-related cytoskeletal adaptations are critical mechanisms inducing the invasive transition of benign breast acini.
Article
Biochemistry & Molecular Biology
Shaohe Wang, Kazue Matsumoto, Samantha R. Lish, Alexander X. Cartagena-Rivera, Kenneth M. Yamada
Summary: The study found that in embryonic salivary glands, budding morphogenesis is driven by the expansion and folding of a specific epithelial surface cell sheet characterized by strong cell-matrix adhesions and weak cell-cell adhesions. Experimental validation showed that cell-matrix adhesion is essential for budding morphogenesis.
Article
Cell Biology
Yuexin Wu, Xiangming Liu, Yue Zhu, Yuemei Qiao, Yuan Gao, Jianfeng Chen, Gaoxiang Ge
Summary: Reprogramming of cancer cell metabolism, particularly through the preference for aerobic glycolysis, plays a critical role in cancer development. The extracellular matrix (ECM), including basement membranes (BMs), in the tumor microenvironment, regulates tumor glycolysis. This study reveals that alpha 5 chain of type IV collagen is a specific microenvironmental regulator in luminal-type breast cancer, modulating cancer cell metabolism and tumor development.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zuopeng Wu, Rebecca A. Sweet, Gerard F. Hoyne, Charmaine J. Simeonovic, Christopher R. Parish
Summary: It has been accepted for decades that T lymphocytes and metastasising tumour cells traverse basement membranes (BM) by deploying a battery of degradative enzymes, particularly proteases. However, recent studies suggest that there are other mechanisms that allow cell migration through basement membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Manuela Pigors, Sabrina Patzelt, Niklas Reichhelm, Jenny Dworschak, Stanislav Khil'chenko, Shirin Emtenani, Katja Bieber, Maxi Hofrichter, Mayumi Kamaguchi, Stephanie Goletz, Gabriele Koehl, Joerg Koehl, Lars Komorowski, Christian Probst, Katrien Vanderheyden, Bianca Balbino, Ralf J. Ludwig, Peter Verheesen, Enno Schmidt
Summary: This study demonstrates that the pathogenic effects of Col17-targeting IgG outside of NC16A are partly mediated by Fc gamma R and C5aR1 mechanisms, and skin inflammation can be alleviated by inhibiting FcRn.
JOURNAL OF PATHOLOGY
(2023)
Article
Biology
Kieop Park, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan B. Thendral, David R. Sherwood
Summary: Separate tissues are connected through adjoining basement membranes to fulfill their barrier, exchange, and support functions. The robust and balanced cell adhesion at these connections is essential for withstanding tissue movement. However, the mechanism by which cells achieve synchronized adhesion to connect tissues remains unclear. This study reveals that type IV collagen both fastens the linkage and activates the collagen receptor DDR-2 in the utse and seam tissues, coordinating the strengthening of integrin adhesion through the LET-60/Ras signaling pathway.
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Review
Genetics & Heredity
David R. Sherwood, Julie Plastino
Article
Biochemistry & Molecular Biology
Daniel P. Keeley, David R. Sherwood
Article
Multidisciplinary Sciences
Jessica H. Hartman, Latasha L. Smith, Kacy L. Gordon, Ricardo Laranjeiro, Monica Driscoll, David R. Sherwood, Joel N. Meyer
SCIENTIFIC REPORTS
(2018)
Review
Genetics & Heredity
David R. Sherwood, Julie Plastino
Article
Cell Biology
Jonathan D. Hibshman, Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, L. Ryan Baugh
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kacy L. Gordon, Sara G. Payne, Lara M. Linden-High, Ariel M. Pani, Bob Goldstein, E. Jane Albert Hubbard, David R. Sherwood
Article
Cell Biology
Laura C. Kelley, Qiuyi Chi, Rodrigo Caceres, Eric Hastie, Adam J. Schindler, Yue Jiang, David Q. Matus, Julie Plastino, David R. Sherwood
DEVELOPMENTAL CELL
(2019)
Article
Cell Biology
Jessica H. Hartman, Christopher T. Richie, Kacy L. Gordon, Danielle F. Mello, Priscila Castillo, April Zhu, Yun Wang, Barry J. Hoffer, David R. Sherwood, Joel N. Meyer, Brandon K. Harvey
EUROPEAN JOURNAL OF CELL BIOLOGY
(2019)
Article
Cell Biology
Ranjay Jayadev, Qiuyi Chi, Daniel P. Keeley, Eric L. Hastie, Laura C. Kelley, David R. Sherwood
JOURNAL OF CELL BIOLOGY
(2019)
Article
Anatomy & Morphology
Meei-Hua Lin, Bill D. Pope, Takako Sasaki, Daniel P. Keeley, David R. Sherwood, Jeffrey H. Miner
DEVELOPMENTAL DYNAMICS
(2020)
Article
Cell Biology
Daniel P. Keeley, Eric Hastie, Ranjay Jayadev, Laura C. Kelley, Qiuyi Chi, Sara G. Payne, Jonathan L. Jeger, Brenton D. Hoffman, David R. Sherwood
DEVELOPMENTAL CELL
(2020)
Article
Biology
Kacy L. Gordon, Jay W. Zussman, Xin Li, Camille Miller, David R. Sherwood
Article
Cell Biology
Claire A. Gianakas, Daniel P. Keeley, William Ramos-Lewis, Kieop Park, Ranjay Jayadev, Isabel W. Kenny, Qiuyi Chi, David R. Sherwood
Summary: The study identifies the crucial role of hemicentin and fibulin-1 in initiating and strengthening basement membrane (BM) attachment. The mechanisms underlying BM-BM linkage maturation are revealed, providing new insights into this specialized form of tissue linkage.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Biology
Kieop Park, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan B. Thendral, David R. Sherwood
Summary: Separate tissues are connected through adjoining basement membranes to fulfill their barrier, exchange, and support functions. The robust and balanced cell adhesion at these connections is essential for withstanding tissue movement. However, the mechanism by which cells achieve synchronized adhesion to connect tissues remains unclear. This study reveals that type IV collagen both fastens the linkage and activates the collagen receptor DDR-2 in the utse and seam tissues, coordinating the strengthening of integrin adhesion through the LET-60/Ras signaling pathway.
Article
Education, Scientific Disciplines
Eric Hastie, Ryan Sellers, Bruno Valan, David R. Sherwood
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION
(2019)