Targeting and transport: How microtubules control focal adhesion dynamics

Rab GTPases and microtubule motors

(2012) Conor P. Horgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

EB1-Recruited Microtubule +TIP Complexes Coordinate Protrusion Dynamics during 3D Epithelial Remodeling

(2012) Sarah Gierke et al.   CURRENT BIOLOGY

Spectraplakins: Master orchestrators of cytoskeletal dynamics

(2012) Kathleen C. Suozzi et al.   JOURNAL OF CELL BIOLOGY

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

(2012) David Meiri et al.   MOLECULAR CELL

Dynamin, a membrane-remodelling GTPase

(2012) Shawn M. Ferguson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

(2012) Neil Bate et al.   PLoS One

Rocket Launcher Mechanism of Collaborative Actin Assembly Defined by Single-Molecule Imaging

(2012) D. Breitsprecher et al.   SCIENCE

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

+TIPs: SxIPping along microtubule ends

(2012) Praveen Kumar et al.   TRENDS IN CELL BIOLOGY

Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β

(2011) Xiaoyang Wu et al.   CELL

Mechanisms of integrin activation and trafficking

(2011) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration

(2011) Christa L. Cortesio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia

(2011) Jonathan R. Bowen et al.   JOURNAL OF CELL BIOLOGY

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

(2011) Zhizhan Gu et al.   JOURNAL OF CELL BIOLOGY

MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin

(2011) F. Shi et al.   JOURNAL OF CELL SCIENCE

The C-terminus of Apc does not influence intestinal adenoma development or progression

(2011) Annabelle Lewis et al.   JOURNAL OF PATHOLOGY

A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src

(2011) Yu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages

(2010) C. Wiesner et al.   BLOOD

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Integrin-Linked Kinase Controls Microtubule Dynamics Required for Plasma Membrane Targeting of Caveolae

(2010) Sara A. Wickström et al.   DEVELOPMENTAL CELL

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

(2010) Shinji Matsumoto et al.   EMBO JOURNAL

The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly

(2010) Claire Rooney et al.   EMBO REPORTS

KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC

(2010) Fanny Jaulin et al.   JOURNAL OF CELL BIOLOGY

Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5α/β

(2010) Azusa Hotta et al.   JOURNAL OF CELL BIOLOGY

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

(2010) Kyoko Okada et al.   JOURNAL OF CELL BIOLOGY

Type I Phosphatidylinositol Phosphate Kinase Beta Regulates Focal Adhesion Disassembly by Promoting  1 Integrin Endocytosis

(2010) W.-T. Chao et al.   MOLECULAR AND CELLULAR BIOLOGY

MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

(2010) Carolina Montenegro-Venegas et al.   MOLECULAR BIOLOGY OF THE CELL

The Spectraplakin Short Stop Is an Actin–Microtubule Cross-Linker That Contributes to Organization of the Microtubule Network

(2010) Derek A. Applewhite et al.   MOLECULAR BIOLOGY OF THE CELL

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration

(2010) Leslie M. Meenderink et al.   PLoS One

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells

(2010) K. Zaoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

(2009) Sara A Wickström et al.   EMBO JOURNAL

Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins

(2009) Wei-Ting Chao et al.   FEBS LETTERS

Cytokinetic astralogy

(2009) Julie C. Canman   JOURNAL OF CELL BIOLOGY

GSK3β phosphorylation modulates CLASP–microtubule association and lamella microtubule attachment

(2009) Praveen Kumar et al.   JOURNAL OF CELL BIOLOGY

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of CLASP2 by GSK-3  regulates its interaction with IQGAP1, EB1 and microtubules

(2009) T. Watanabe et al.   JOURNAL OF CELL SCIENCE

Guanine Nucleotide Exchange Factor-H1 Regulates Cell Migration via Localized Activation of RhoA at the Leading Edge

(2009) Perihan Nalbant et al.   MOLECULAR BIOLOGY OF THE CELL

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration

(2009) Cai Huang et al.   NATURE CELL BIOLOGY

Integrins: masters and slaves of endocytic transport

(2009) Patrick T. Caswell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

The heel and toe of the cell's foot: A multifaceted approach for understanding the structure and dynamics of focal adhesions

(2009) Haguy Wolfenson et al.   CELL MOTILITY AND THE CYTOSKELETON

ACF7 Regulates Cytoskeletal-Focal Adhesion Dynamics and Migration and Has ATPase Activity

(2008) Xiaoyang Wu et al.   CELL

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

Myosin II Activity Facilitates Microtubule Bundling in the Neuronal Growth Cone Neck

(2008) Dylan T. Burnette et al.   DEVELOPMENTAL CELL

Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites

(2008) A. Efimov et al.   JOURNAL OF CELL SCIENCE

Microtubule-mediated Src Tyrosine Kinase Trafficking in Neuronal Growth Cones

(2008) Bingbing Wu et al.   MOLECULAR BIOLOGY OF THE CELL

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization

(2008) Angela I.M. Barth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY