Article
Gastroenterology & Hepatology
Charlotte Desprez, Guillaume Gourcerol, Celine Savoye-Collet, Valerie Bridoux, Thomas Duflot, Anne-Marie Leroi
Summary: This study investigated the relationship between anal sphincter function and faecal incontinence (FI) subtypes, finding that the anal sphincter distensibility index (DI) using the EndoFLIP(R) system displayed poor predictive performance in distinguishing among FI subtypes.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Rose Q. Trieu, Yoav Mazor, Gillian Prott, Michael P. Jones, John E. Kellow, Margaret Schnitzler, Allison Malcolm
Summary: This study found that women with isolated flatus incontinence have different clinical and physiological characteristics compared to healthy women and women with fecal incontinence. It suggests that flatus incontinence may be a precursor or part of the spectrum of fecal incontinence, rather than just a normal phenomenon.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Francesco Litta, Angelo A. Marra, Nuria Ortega Torrecilla, Raffaele Orefice, Angelo Parello, Veronica De Simone, Paola Campenni, Marta Goglia, Carlo Ratto
Summary: This prospective clinical study evaluated changes in external anal sphincter contractility after implantation of a self-expandable hyexpan prostheses, showing improvements in clinical outcomes.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Rehabilitation
Seung Hee Han, Kyungyeul Choi, Ga Yang Shim, JongKyu Kim
Summary: The study compared the clinical value of pudendal nerve terminal motor latency and anorectal manometry in fecal incontinence patients. The results showed that there was a significant correlation between pudendal nerve terminal motor latency and anorectal manometry only in nondiabetic patients.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Review
Gastroenterology & Hepatology
Dakshitha Wickramasinghe, Nilanka Wickramasinghe, Sohan Anjana Kamburugamuwa, Nandadeva Samarasekera, Janindra Warusavitarne, Carolynne Vaizey
Summary: A systematic review on the difference in sphincter fatigability between patients with and without anal incontinence found that patients with AI had significantly lower squeeze pressure and a lower Fatigability Rate Index compared to those without AI, indicating good discriminating power for anal incontinence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Minsung Kim, Bo-Young Oh, Ji-Seon Lee, Dogeon Yoon, You-Rin Kim, Wook Chun, Jong Wan Kim, Il Tae Son
Summary: This study demonstrated for the first time that implanted adipose-derived stem cells can restore impaired smooth muscle cells at the injury site, showing stem cell fate corresponding to the established IAS-specific AI model.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Vanessa N. Vandruff, Julia R. Amundson, Stephanie Joseph, Simon Che, Kristine Kuchta, Christopher J. Zimmermann, Shun Ishii, H. Mason Hedberg, Michael B. Ujiki
Summary: Impedance planimetry and panometry are sensitive tools for assessing motility under general anesthesia or sedation, showing potential as alternatives to high-resolution manometry, particularly in patients with difficult access or tolerance issues.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Daniel L. Cohen, Amir Mari, Anton Bermont, Dana Zelnik Yovel, Vered Richter, Haim Shirin
Summary: This study retrospectively reviewed high-resolution anorectal manometry (ARM) studies in a multiethnic population. The findings showed that there were differences in ARM results based on ethnicity, with higher rates of fecal incontinence and lower anal pressure and muscle contractility in the Arab Israeli group. Further research is needed to determine the clinical relevance of these findings in ethnically diverse populations.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Surgery
Bailey Su, Mikhail Attaar, Harry Wong, Zachary M. Callahan, Kristine Kuchta, Stephen Stearns, John G. Linn, Woody Denham, Stephen P. Haggerty, Michael B. Ujiki
Summary: This study found that a 40 ml balloon volume fill resulted in higher measurements of Dmin, CSA, IBP, and DI during fundoplication compared to a 30 ml fill. Reverse Trendelenburg positioning led to higher Dmin, IBP, and CSA values, while pneumoperitoneum significantly increased IBP but decreased DI. Surgeons should consider these variables when interpreting FLIP measurements during or after fundoplication.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Claudio Morera, Samuel Nurko, Leonel Rodriguez
Summary: The study evaluated the utility of motility studies in pediatric functional constipation, finding that patients with fecal incontinence had higher frequency of normal motility parameters than those without, but overall interpretation was not different. Colonic manometry helped predict therapy response in functional constipation without fecal incontinence, while anorectal manometry showed no added benefit in the evaluation of functional constipation with/without fecal incontinence.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Marcin Banasiuk, Marcin Dziekiewicz, Magdalena Dobrowolska, Barbara Skowronska, Lukasz Dembinski, Aleksandra Banaszkiewicz
Summary: The study evaluates children with non-retentive fecal incontinence (NRFI) using three-dimensional high-resolution anorectal manometry (3D-HRAM). It finds lower pressure parameters in children with NRFI and suggests that 3D-HRAM may reveal segments with decreased pressures in patients with normal resting pressures.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Cell Biology
Alexandre Balaphas, Jeremy Meyer, Raphael P. H. Meier, Emilie Liot, Nicolas C. Buchs, Bruno Roche, Christian Toso, Leo H. Buhler, Carmen Gonelle-Gispert, Frederic Ris
Summary: Anal sphincter incontinence is a chronic disease that significantly impacts quality of life, with surgery showing disappointing success rates. Stem/progenitor cell therapy is being considered as a promising alternative with higher efficacy, but further research and development is necessary to overcome challenges and establish optimal treatment protocols.
Article
Gastroenterology & Hepatology
Lori J. Tuttle, Ali Zifan, Jessica Swartz, Ravinder K. Mittal
Summary: The study found that biofeedback therapy incorporating concentric resistance exercise did not significantly improve anal sphincter muscle function or AI symptoms compared to traditional non-resistance biofeedback therapy.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Alexander O'Connor, Caroline M. Byrne, Dipesh H. Vasant, Abhiram Sharma, Donghua Liao, Niels Klarskov, Edward S. Kiff, Karen Telford
Summary: This review presents the current and potential future applications of AAR and FLIP techniques, highlighting the unanswered questions associated with these novel technologies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Sushmitha Grama Srinivasan, Anjani Muthyala, Mayank Sharma, Kelly Feuerhak, Andrea Boon, Kent R. Bailey, Adil E. Bharucha
Summary: This study found three possibly interrelated abnormalities in DD, including aberrant activation of abdominal muscles during squeeze in DD, dyscoordination of abdominal muscles during various tasks in constipated women, and abdomino-anal dyscoordination.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Charlotte Desprez, Henri Damon, Guillaume Meurette, Diane Mege, Jean-Luc Faucheron, Charlene Brochard, Elsa Lambrescak, Guillaume Gourcerol, Francois Mion, Vincent Wyart, Igor Sielezneff, Laurent Siproudhis, Isabelle Etienney, Nadine Ajamie, Paul-Antoine Lehur, Thomas Duflot, Valerie Bridoux, Anne-Marie Leroi
Summary: The effectiveness of sacral nerve modulation (SNM) was assessed in a large cohort of patients implanted for at least 10 years. The study found that approximately half of the patients with fecal incontinence maintained long-term efficacy after SNM treatment.
Article
Multidisciplinary Sciences
Mathieu Meleine, Lourdes Mounien, Karim Atmani, Wassila Ouelaa, Christine Bole-Feysot, Charlene Guerin, Inge Depoortere, Guillaume Gourcerol
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Marion Chambaz, Chloe Melchior, Paul Basile, Gaetan Prevost, Jeremie Jacques, Anne-Marie Leroi, Guillaume Gourcerol
Summary: Recent studies have shown that pyloric distensibility is altered in 30-50% of gastroparetic patients, but the correlation between pyloric sphincter measurements and diabetes characteristics was not found in this study. Both diabetic and idiopathic gastroparesis showed altered pyloric sphincter distensibility and pressure.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Editorial Material
Psychiatry
Andreas Stengel, Guillaume Gourcerol, Yvette Tache
FRONTIERS IN PSYCHIATRY
(2021)
Correction
Pharmacology & Pharmacy
Chloe Melchior, Charlotte Desprez, Fabien Wuestenberghs, Anne-Marie Leroi, Antoine Lemaire, Guillaume Gourcerol
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jolien Schol, Lucas Wauters, Ram Dickman, Vasile Drug, Agata Mulak, Jordi Serra, Paul Enck, Jan Tack
Summary: A group of European experts reached a consensus on the definition, symptom characteristics, pathophysiology, diagnosis, and management of gastroparesis; Gastroparesis is often accompanied by symptoms such as nausea, vomiting, and may be associated with diabetes, neurological diseases, etc.; There is currently no consensus on the definitive treatment for this condition.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Lucas Wauters, Ram Dickman, Vasile Drug, Agata Mulak, Jordi Serra, Paul Enck, Jan Tack, Anna Accarino, Giovanni Barbara, Serhat Bor, Benoit Coffin, Maura Corsetti, Heiko De Schepper, Dan Dumitrascu, Adam Farmer, Guillaume Gourcerol, Goran Hauser, Trygve Hausken, George Karamanolis, Daniel Keszthelyi, Carolin Malagelada, Tomislav Milosavljevic, Jean Muris, Colm O'Morain, Athanassos Papathanasopoulos, Daniel Pohl, Diana Rumyantseva, Giovanni Sarnelli, Edoardo Savarino, Jolien Schol, Arkady Sheptulin, Annemieke Smet, Andreas Stengel, Olga Storonova, Martin Storr, Hans Tornblom, Tim Vanuytsel, Monica Velosa, Marek Waluga, Natalia Zarate, Frank Zerbib
Summary: Functional dyspepsia is a common condition in clinical practice, but there are major uncertainties regarding its definition, underlying pathophysiology, diagnosis, treatment, and prognosis. A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of FD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Editorial Material
Gastroenterology & Hepatology
Fabien Wuestenberghs, Guillaume Gourcerol
Summary: This article is linked to Kuo et al papers, click the link to view the articles.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Gastroenterology & Hepatology
Fabien Wuestenberghs, Guillaume Gourcerol
Summary: Recent research indicates that pyloric distensibility may serve as an important indicator for evaluating patients with gastroparesis, as its decrease is strongly correlated with gastric emptying and symptoms. Furthermore, pyloric distensibility may also predict the efficacy of endoscopic techniques targeting the pylorus.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Letter
Clinical Neurology
Nathalie Chastan, Najate Achamrah, Stephane Derrey, David Maltete, Moise Coeffier, Anne-Marie Leroi, Pierre Dechelotte, Marie-Laure Welter, Guillaume Gourcerol
Article
Gastroenterology & Hepatology
Pauline Riviere, Blandine Vauquelin, Emiliane Rolland, Chloe Melchior, Sabine Roman, Stanislas Bruley des Varannes, Francois Mion, Guillaume Gourcerol, Sylvie Sacher-Huvelin, Frank Zerbib
Summary: The study found that both a low FODMAP diet and usual dietary advice had similar but limited beneficial effects on symptoms in patients with PPI refractory GERD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Nicolas Richard, Charlotte Desprez, Fabien Wuestenberghs, Anne-Marie Leroi, Guillaume Gourcerol, Chloe Melchior
Summary: The study investigated the efficacy of different antibiotics in treating small intestinal bacterial overgrowth. Remission was observed in over half of the patients after one course of antibiotics, with rotating antibiotics showing more effectiveness than a single antibiotic. Remission was associated with significant improvements in quality of life and bloating.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Neurosciences
Heithem Soliman, Benoit Coffin, Guillaume Gourcerol
Summary: Patients with Parkinson's disease often experience gastrointestinal symptoms like gastroparesis, which can significantly impact their quality of life. These symptoms may precede motor symptoms and are linked to the presence of α-synuclein aggregates in the enteric nervous system. Proper diagnosis and treatment, including dietary modifications and pharmacologic agents, are crucial for managing these gastrointestinal issues in PD patients.
Article
Gastroenterology & Hepatology
Sofya Latrache, Chloe Melchior, Charlotte Desprez, Sabrina Sidali, Julien Recton, Olivier Touchais, Elise van der Eecken, Fabien Wuestenberghs, Cloe Charpentier, Anne Marie Leroi, Guillaume Gourcerol
Summary: Esophageal motility disorders of secondary origin are not uncommon, with predictive factors including smoking, age ≥58 years, and an Integrated Relaxation Pressure higher than 10 mmHg. Morphological assessment using endoscopic ultrasonography and/or computed tomography may be useful for diagnosing a secondary origin, especially in the elderly and smokers.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Guillaume Gourcerol, Benoit Coffin, Bruno Bonaz, Helene Hanaire, Stanislas Bruley Des Varannes, Frank Zerbib, Robert Caiazzo, Jean Charles Grimaud, Francois Mion, Samy Hadjadj, Paul Valensi, Lucine Vuitton, Guillaume Charpentier, Alain Ropert, Romain Altwegg, Philippe Pouderoux, Etienne Dorval, Michel Dapoigny, Henri Duboc, Pierre Yves Benhamou, Aurelie Schmidt, Nathalie Donnadieu, Philippe Ducrotte, Bruno Guerci
Summary: The study aimed to evaluate the efficacy, safety, and medico-economic impact of Enterra therapy for chronic medically refractory nausea and vomiting. The results showed that Enterra therapy significantly improved the gastrointestinal quality of life index score and reduced vomiting frequency. It also decreased healthcare costs and resulted in savings for the patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)