Article
Clinical Neurology
Dingjun Hao, Jinpeng Du, Liang Yan, Baorong He, Xiao Qi, Shicheng Yu, Jiaojiao Zhang, Wenjing Zheng, Rongqiang Zhang, Da-Geng Huang, Junsong Yang, Ming Zhu, Jiawei Ouyang, He Zhao, Keyuan Ding, Haodong Shi, Yang Cao, Ying Zhang, Qinghua Tang, Yuan Liu, Zilong Zhang, Yuhang Wang, Ye Tian, Hao Chen, Lulu Bai, Heng Li, Chenchen Mu, Youhan Wang, Xiaohui Wang, Chao Jiang, Jianhua Lin, Bin Lin, Shunwu Fan, Lin Nie, Jiefu Song, Xun Ma, Zengwu Shao, Yanzheng Gao, Zhong Guan, Yueming Song, Weihu Ma, Qixin Chen
Summary: The incidence of TSCI in China significantly increased from 2009 to 2018, especially among the elderly population. The mortality rate of TSCI patients in hospitals is relatively low, but elderly individuals remain at a high risk of hospital death.
EUROPEAN SPINE JOURNAL
(2021)
Review
Health Care Sciences & Services
Guilian Chen, Tong Wang, Lirong Zhong, Xinghui He, Chunxia Huang, Yingmin Wang, Kun Li
Summary: Telemedicine is a feasible way to prevent pressure injuries among patients with spinal cord injuries. It can decrease the incidence and severity of pressure injuries and accelerate patients' healing without imposing an economic burden. It is best used in tandem with other, more conventional interventions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Clinical Neurology
Yannick Rau, Arndt-Peter Schulz, Roland Thietje, Ludwig Matrisch, Jasper Frese, Sven Hirschfeld
Summary: This study provides recent data on the incidence of spinal cord injuries (SCI) in Germany and highlights the influence of age, gender, and type of lesion on incidence rates. The findings suggest potential directions for future research, particularly regarding the relative reduction in complete injuries among the elderly.
EUROPEAN SPINE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Li Deng, Jun Qiao Lv, Lin Sun
Summary: This study systematically analyzed the experimental treatments and their mechanisms for reducing blood spinal cord barrier (BSCB) injury in the early stage of traumatic spinal cord injury (t-SCI). BMSC-Exos, which inhibit matrix metalloproteinases (MMPs) expression, are currently the most effective therapeutic modality for alleviating BSCB damage. In addition, the regulation of MMPs, the Akt pathway, and the ER stress pathway play important roles in alleviating BSCB injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Orthopedics
Fater A. Khadour, Younes A. Khadour, Ling Meng, Lixin Cui, Xu Tao
Summary: This hospital-based retrospective study described the epidemiological characteristics of traumatic spinal cord injury in Wuhan, China. Findings revealed a higher proportion of males, with falls and traffic accidents being the leading causes. Farmers and workers were the most vulnerable occupations, and attention should be paid to the fall risk among the elderly. The importance of SCI rehabilitation should be highlighted.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Cell Biology
Farihah Iqbal Khan, Zubair Ahmed
Summary: Spinal cord injury (SCI) is a complex and prolonged injury process that leads to loss of neurological functions. Current treatments are limited and novel treatments targeting ongoing injury processes are needed. In a systematic review of studies, combined tetrahedral framework nucleic acid with neural stem cells and Fortasyn (R) Connect supplementation showed significant improvements in functional recovery and attenuated secondary injury processes.
Review
Biotechnology & Applied Microbiology
Mengdie Hu, Zhidong Cao, Dianming Jiang
Summary: MiRNA-modified exosomes have great potential in the treatment of spinal cord injury, and their efficacy is superior to that of exosomes alone. In addition, the SCI model, administration time, and dose have an impact on the treatment effect.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ezra Valido, Gabriela Boehl, Joerg Krebs, Juergen Pannek, Stevan Stojic, Atanas G. Atanasov, Marija Glisic, Jivko Stoyanov, Athanasia Mouzaki
Summary: Individuals with spinal cord injury (SCI) have higher infection rates compared to those without SCI. This review investigated the immune status difference between individuals with SCI and without SCI by examining their peripheral immune cells and markers. The results showed that immune cells in individuals with SCI had lower functional capability and exhibited higher levels of leukocytes, neutrophils, C-reactive protein (CRP), and IL6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
James A. G. Crispo, Lisa J. W. Liu, Vanessa K. Noonan, Nancy P. Thorogood, Brian K. Kwon, Marcel F. Dvorak, Dylan Thibault, Allison W. Willis, Jacquelyn J. Cragg
Summary: This study aimed to describe national trends in emergency department (ED) visits for traumatic spinal cord injury (tSCI) among children in the United States. It found that the annual ED visit rate for tSCI remained stable between 2016 and 2020, with approximately 2,200 new pediatric ED visits for tSCI annually. The study also revealed that most ED visits for tSCI were by older children (15-20 years) and males, who were more likely to be admitted to the hospital. Additionally, it identified American tackle football as the leading cause of sports-related tSCI among children and suggested a possible increase in sports-related tSCI over time.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Sung Huang Laurent Tsai, Chun-Ru Lin, Shih-Chieh Shao, Chao-Hua Fang, Tsai-Sheng Fu, Tung-Yi Lin, Yu-Chiang Hung
Summary: This study evaluated the efficacy and safety of cannabinoids for pain reduction in spinal cord injury (SCI) patients through a systematic review and meta-analysis. The findings suggest that cannabinoids may not provide significant pain relief for SCI patients and may increase the likelihood of adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
P. Sreeharsha, Rishi Mugesh Kanna, Raunak Milton, Ajoy Prasad Shetty, S. Rajasekaran
Summary: The incidence and risk factors for complications, length of stay, and mortality after traumatic spinal injuries were analyzed in this study. Chest injuries, cervical spine injury, complete neurological deficit, and ankylosing spondylitis were key predictors of mortality, while age and thoracic injuries contributed to higher morbidity and prolonged hospitalization.
EUROPEAN SPINE JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Xue-Yan Zheng, Qian Yi, Xiao-Jun Xu, Rui-Lin Meng, Shu-Li Ma, Si-Li Tang, Hao-Feng Xu, Ying-Shan Xu, Yan-Jun Xu, Yi Yang
Summary: The study found that traumatic brain injury mortality remained relatively stable, while spinal cord injury mortality increased significantly from 2014 to 2018. Males, rural residents, and older individuals had higher adjusted mortality rate ratios for both TBI and SCI. Motor vehicle crashes and falls were the leading causes of TBI mortality, while falls were the most important external cause of SCI death across all ages.
Article
Veterinary Sciences
Mathieu Montoya, Jo Ann Morrison, Florent Arrignon, Nate Spofford, Helene Charles, Marie-Anne Hours, Vincent Biourge
Summary: This study generated life expectancy tables for dogs and cats using clinical records from over 1,000 Banfield Pet hospitals in the USA. These tables provide valuable information for veterinarians and pet owners, and serve as a foundation for further research.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Medicine, General & Internal
Peter Francis Raguindin, Alessandro Bertolo, Ramona Maria Zeh, Gion Frankl, Oche Adam Itodo, Simona Capossela, Lia Bally, Beatrice Minder, Mirjam Brach, Inge Eriks-Hoogland, Jivko Stoyanov, Taulant Muka, Marija Glisic
Summary: Individuals with tetraplegia tend to have higher fat composition and higher indicators of central adiposity compared to those with paraplegia, while also exhibiting lower lean mass. This study suggests that anthropometric measures, such as body mass index, may not accurately reflect adiposity in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Anne Buzzell, Jonviea D. Chamberlain, Martin Schubert, Gabi Mueller, David J. Berlowitz, Martin W. G. Brinkhof, Xavier Jordan, Fabienne Reynard, Michael Baumberger, Hans Peter Gmuender, Armin Curt, Margret Hund-Georgiadis, Kerstin Hug, Charly Freitag, Daniel Joggi, Hardy Landolt, Nadja Muenzel, Mirjam Brach, Gerold Stucki, Christine Fekete
Summary: This study found that individuals with Spinal Cord Injuries (SCI) in Switzerland experience more sleep problems compared to the general population, with a significant portion not receiving treatment. People aged 46-60, experiencing severe financial hardship, and reporting pain are more likely to have chronic sleep problems.
JOURNAL OF SPINAL CORD MEDICINE
(2021)
Article
Clinical Neurology
Anne Buzzell, Jonviea D. Chamberlain, Inge Eriks-Hoogland, Xavier Jordan, Martin Schubert, Marcel Zwahlen, Martin W. G. Brinkhof
Summary: An observational, population-based cohort study conducted in specialized rehabilitation centers in Switzerland found that survival differences among non-traumatic spinal cord injury (NTSCI) patients were mainly influenced by etiology, with malignant etiologies having the highest hazard ratios. The study suggests that causal differences in survival among NTSCI etiological groups are likely due to chronic variation in health conditions, supporting the development of long-term interdisciplinary management and policies for NTSCI patients specific to etiology.
Article
Clinical Neurology
Anne Buzzell, Kamilla Coutinho Camargos, Jonviea D. Chamberlain, Inge Eriks-Hoogland, Kerstin Hug, Xavier Jordan, Martin Schubert, Martin W. G. Brinkhof
Summary: This study identified systematic differences in the report of health conditions and their treatment within the Swiss spinal cord injury community. Factors such as age, time since injury, severity of health conditions, and financial difficulties were associated with the propensity for reporting treatment.
Article
Clinical Neurology
Urban Schwegler, Christine Fekete, Monika Finger, Katarzyna Karcz, Stefan Staubli, Martin W. G. Brinkhof
Summary: The study found that labor market participation of individuals with spinal cord injury is influenced by various factors, including static, temporal, dynamic, and policy-related determinants. Counterfactual predictions suggest that strategies focusing on improving functional independence, education levels, and partial disability pensions can lead to increased employment rates.
Article
Clinical Neurology
Jonviea D. Chamberlain, Anais Rouanet, Bruno Dubois, Florence Pasquier, Olivier Hanon, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Yannick Bejot, Olivier Godefroy, David Wallon, Armelle Gentric, Genevieve Chene, Carole Dufouil
Summary: The study found that incident cancer was associated with a reduced risk of dementia, suggesting a protective relationship between cancer and dementia. Further investigations are encouraged to understand potential underlying mechanisms.
ALZHEIMERS & DEMENTIA
(2021)
Article
Medicine, General & Internal
Andreas D. Haas, Cordelia Kunzekwenyika, Stefanie Hossmann, Josphat Manzero, Janneke van Dijk, Ronald Manhibi, Ruth Verhey, Andreas Limacher, Per M. von Groote, Ethel Manda, Michael A. Hobbins, Dixon Chibanda, Matthias Egger
Summary: In rural Zimbabwe, a significant proportion of people living with HIV are affected by common mental disorders (CMD), with higher rates in women and adults aged 40-59. Positive CMD screens are associated with suboptimal ART adherence.
Article
Medicine, General & Internal
Anneke Hertig-Godeschalk, Martin W. G. Brinkhof, Anke Scheel-Sailer, Claudio Perret, Andreas Jenny, Gunter Landmann, Patrik O. Wyss, Joelle Leonie Flueck
Summary: Vitamin D insufficiency is prevalent in individuals with spinal cord injuries, affecting musculoskeletal, immune, and respiratory system function. This study aims to investigate the impact of 12-month vitamin D supplementation on vitamin D status and other parameters in chronic SCI patients.
Article
Pediatrics
Sadia Khan, El Hassane Ouaalaya, Jonviea D. Chamberlain, Marie-Noelle Dufourg, Marie-Aline Charles, Chantal R. Semjen
Summary: This study validates the effectiveness of a non-invasive asthma prediction tool in different populations, providing encouragement for its application by general practitioners.
PEDIATRIC PULMONOLOGY
(2022)
Article
Clinical Neurology
Collene E. Anderson, Veronika Birkhauser, Martina D. Liechti, Xavier Jordan, Eugenia Luca, Sandra Mohr, Jurgen Pannek, Thomas M. Kessler, Martin W. G. Brinkhof
Summary: This prospective, multicenter, longitudinal cohort study aimed to investigate the female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation. The study found that females were more likely to use bladder storage medication and suprapubic catheters during SCI rehabilitation. These findings highlight the need for further research on female-specific urological management in SCI.
Article
Chemistry, Multidisciplinary
Jean-Pierre Ghobril, Dusan Petrovic, Georg Ehret, Belen Ponte, Menno Pruijm, Daniel Ackermann, Bruno Vogt, Silvia Stringhini, Aurelien Thomas, Jonviea Chamberlain, Semira Gonseth-Nussle, Murielle Bochud
Summary: The recent development of high-throughput sequencing technologies has allowed researchers to explore the contribution of genomic, epigenomic, transcriptomic, or proteomic variants to complex phenotypic traits. In this study, large-scale Genome-Wide Association Studies (GWAS) and Epigenome-Wide Association Studies (EWAS) were conducted to investigate the associations between genomic and epigenomic markers with multiple phenotypic traits in a population-based context. The results were made available through the web-based platform, PhenoExplorer, with the aim of providing open access to the tested associations.
Article
Oncology
Jonviea D. Chamberlain, Sebastien Nussle, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E. Harris, Janie Corley, Simon R. Cox, Semira Gonseth Nussle
Summary: This study identified and validated novel epigenetic signatures of tobacco and alcohol consumption, which were found to be highly correlated with self-reported exposure status and associated with long-term health outcomes. Epigenetic signatures of lifestyle exposures may help reduce measurement issues and biases, and could potentially assist in risk stratification for early-stage targeted interventions.
CLINICAL EPIGENETICS
(2022)
Article
Public, Environmental & Occupational Health
Andreas D. Haas, Raphael Lienhard, Christiane Didden, Morna Cornell, Naomi Folb, Tebatso M. G. Boshomane, Luisa Salazar-Vizcaya, Yann Ruffieux, Patience Nyakato, Anja E. Wettstein, Mpho Tlali, Mary-Ann Davies, Per von Groote, Milton Wainberg, Matthias Egger, Gary Maartens, John A. Joska
Summary: We conducted a study in a South African private-sector HIV program to assess adherence and viral suppression rates among adolescents and adults living with HIV. Participants with mental health diagnoses had poorer adherence patterns and a higher risk of viral non-suppression. Males, adolescents, and young adults also had an increased risk of viral non-suppression. Our findings emphasize the need for psychosocial interventions and improved mental health services in HIV treatment programs.
Article
Medicine, General & Internal
Jonviea D. Chamberlain, Sebastien Nussle, Murielle Bochud, Semira Gonseth-Nussle
Summary: This study aims to assess the association between Youth Capital (YC) and epigenetic signatures of lifestyle exposures with COVID-19 severity, and to evaluate whether these signatures can improve the prediction of COVID-19 severity. The findings suggest that epigenetic age and lifestyle factors may play a role in the risk of severe COVID-19 symptoms.
SWISS MEDICAL WEEKLY
(2023)
Article
Urology & Nephrology
Collene E. Anderson, Veronika Birkhaeuser, Xavier Jordan, Martina D. Liechti, Eugenia Luca, Sandra Moehr, Juergen Pannek, Thomas M. Kessler, Martin W. G. Brinkhof
Summary: This study aimed to describe neurogenic lower urinary tract dysfunction management in Swiss SCI centers utilizing the EAU Guidelines. The findings suggest that a majority of SCI patients have lower urinary tract problems at discharge, with complete SCI patients being more prone to urological issues, and females having a higher risk of urinary incontinence.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
