Article
Neurosciences
Rui Mao, Xiaoyun Zhang, Youyong Kong, Shanshan Wu, Hai-qin Huo, Yue Kong, Zhen Wang, Yan Liu, Zhengping Jia, Zikai Zhou
Summary: This study reveals the important role of ALK in neurodevelopment, as transient embryonic ALK inactivation can affect the structure and function of the adult brain. Through scRNA-seq, it was found that ALK influences differentially expressed genes at different developmental stages, many of which are associated with neurological or neuropsychiatric disorders.
Article
Immunology
Jennifer K. King, Tiffany M. Tran, May H. Paing, Yuxin Yin, Amit K. Jaiswal, Ching-Hsuan Tso, Koushik Roy, David Casero, Dinesh S. Rao
Summary: The microRNA miR-146a is a negative regulator of the immune transcription factor NFκB and plays important roles in the immune system. Its deficiency leads to chronic inflammation and autoimmune disease. This study found that miR-146a suppresses B-cell responses and identified TRAF6 as a target gene. TRAF6 was shown to be required for proliferation in these B-cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ace E. Lewis, Akela Kuwahara, Jacqueline Franzosi, Jeffrey O. Bush
Summary: This study reveals the role of the Efnb2 gene in regulating tracheoesophageal separation by controlling the dorsoventral allocation of tracheal-fated cells. It also uncovers the mechanism of how NKX2-1 coordinates tracheal specification with tissue separation through the regulation of EPHRIN-B2 and tracheoesophageal cell sorting.
Article
Multidisciplinary Sciences
Yu-Lin Chen, Yi-Chen Yen, Chuan-Wei Jang, Ssu-Han Wang, Hsin-Ting Huang, Chung-Hsing Chen, Jenn-Ren Hsiao, Jang-Yang Chang, Ya-Wen Chen
Summary: EPHA10 is implicated in tumor growth and metastasis of oral squamous cell carcinoma, with its ligand EFNA4 inducing cell migration and up-regulation of SNAIL, NANOG, and OCT4. Inhibition of ERK and knockdown of NANOG abolish these effects, suggesting a potential therapeutic target for OSCC.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Moawiah M. Naffaa, Rehan R. Khan, Chay T. Kuo, Henry H. Yin
Summary: This study identifies a neural circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone. Glutamatergic projections from the anterior cingulate cortex and inhibitory projections from local interneurons modulate the activity of cholinergic neurons in the subependymal zone. Optogenetic stimulation and inhibition of this circuit can control neurogenesis in the ventral SVZ.
Article
Biochemistry & Molecular Biology
Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei, Ying Cao
Summary: The property of neural stemness contributes to cell tumorigenicity, and tumor phenotypic heterogeneity might be an effect of differentiation potential of neural stemness. The importance of neural genes in evolution is highlighted, indicating that tumorigenesis is a process of cells restoring a neural ground state along an evolutionary route pre-determined by the advantage of a neural state.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Huimin Zhao, Jie Wei, Yanan Du, Peipei Chen, Xiaoquan Liu, Haochen Liu
Summary: Alzheimer's disease (AD) is an age-related neurological dysfunction and current treatments have limited clinical benefits. A study showed that DMP1 can induce cell-cycle arrest in neural progenitor cells and may affect cognitive function in Alzheimer-like mice. Silencing DMP1 increased the number of neural progenitor cells and improved cognitive function in Alzheimer-like mice.
Article
Developmental Biology
Carrie Lynn Hehr, Rami Halabi, Sarah McFarlane
Summary: This study investigates the role of the secreted signaling molecule Sema3fa in the development of zebrafish retina. The results indicate that Sema3fa acts on temporal progenitors during embryogenesis to control the production of amacrine cells, possibly for the establishment of neural circuits with domain-specific functions.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Dexiao Zhu, Jian Zhang, Fei Gao, Mei Hu, Jack Hashem, Chu Chen
Summary: 2-AG, the most abundant endocannabinoid, has anti-inflammatory and neuroprotective properties. Inhibition of its degradation enzyme MAGL improves synaptic and cognitive functions in neurodegenerative disease models. However, the molecular mechanisms behind this enhancement are still unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Xi Gu, Xiaona Xu, Chunhong Jia, Junhao Wang, Jiwen Zhang, Qiong Gao, Jiawei Chen
Summary: miR-124, accounting for more than a quarter of total miRNAs in the brain, is a highly expressed miRNA in the nervous system. It plays important roles in regulating neurogenesis, neuronal differentiation, neuronal maturation, and synapse formation. Furthermore, it has been shown to be associated with the pathogenesis of various neurodevelopmental and neuropsychiatric disorders. This review provides an overview of the role and underlying mechanisms of miR-124 in neurodevelopment and prospects its significance in neuroscience research.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yishan Dong, Ming Zhang, Jun Ouyang, Wenbai Zhou, Bin Yu
Summary: The study reveals the increased presence of tumor-derived endothelial cells and the important role of EFNB2 in endometriosis, which is associated with the risk of recurrence.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Hung-Yu Shih, Hao-Yuan Chen, Yin-Cheng Huang, Tu-Hsueh Yeh, Yi-Chieh Chen, Yi-Chuan Cheng
Summary: In the development of neural progenitor cells, the transcription factor etv5a regulates cell proliferation by directly suppressing the expression of sox2 and indirectly regulating foxm1 expression.
STEM CELLS AND DEVELOPMENT
(2023)
Review
Biochemistry & Molecular Biology
Phillip P. Domeier, Ziaur S. M. Rahman
Summary: There are three classes of interferons that can promote the development of autoimmune diseases like SLE by promoting the generation of autoreactive B cells and autoantibodies through distinct signaling mechanisms. Treatment outcomes of SLE patients receiving interferon-blocking therapies vary, suggesting that environmental and genetic factors may influence how these cytokines contribute to the development of autoreactive B cells and SLE. Understanding how each class of interferon controls B cell responses in SLE is crucial for developing optimized therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Shuang Li, Chengdong Liu, Allison Goldstein, Yi Xin, Caihuan Ke, Cunming Duan
Summary: Using a zebrafish model, it was found that Stc1a plays a key role in regulating the balance between cell quiescence and proliferation, specifically in Ca2+ transporting epithelial cells. Stc1a promotes ionocyte quiescence by suppressing local IGF signaling activity, and its genetic deletion leads to increased ionocyte proliferation, elevated body Ca2+ levels, and premature death. This study uncovers a novel pathway that is Ca2+ state-dependent in regulating cell quiescence and provides insights into the importance of ionocyte quiescent-proliferation balance in organismal Ca2+ homeostasis and survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jinfeng Hu, Dun Pan, Guo Li, Kunqi Chen, Xiangming Hu
Summary: In recent years, the number of marathon events worldwide has increased, making the half marathon the sports event with the most participants. However, most runners lack knowledge and guidance on injury prevention, leading to an increasing number of injuries associated with the event. Studies have shown that wearing compression shorts can improve hip extension proprioception in football players and wearing graduated compression socks can maintain ankle proprioception after a half-marathon.
CELL DEATH & DISEASE
(2022)
Review
Developmental Biology
Colin J. Dinsmore, Philippe Soriano
DEVELOPMENTAL BIOLOGY
(2018)
Article
Developmental Biology
Andrei Molotkov, Philippe Soriano
DEVELOPMENTAL BIOLOGY
(2018)
Editorial Material
Biology
Philippe Soriano
SCIENCE CHINA-LIFE SCIENCES
(2018)
Article
Developmental Biology
Agata Kurowski, Andrei Molotkov, Philippe Soriano
DEVELOPMENTAL BIOLOGY
(2019)
Editorial Material
Developmental Biology
Philippe Soriano
DEVELOPMENTAL BIOLOGY
(2019)
Editorial Material
Cell Biology
Colin J. Dinsmore, Philippe Soriano
DEVELOPMENTAL CELL
(2020)
Review
Cell Biology
James F. Clark, Colin J. Dinsmore, Philippe Soriano
GENES & DEVELOPMENT
(2020)
Correction
Cell Biology
Ayan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe Soriano
GENES & DEVELOPMENT
(2021)
Article
Developmental Biology
Colin J. Dinsmore, Chen-Yeh Ke, Philippe Soriano
Summary: The widely used Wnt1-Cre transgenic mouse line overexpresses WNT1, which can lead to undesired phenotypes. The Wnt1-Cre2 line was developed to address this issue, but it exhibits unexpected activity in the male germline, potentially due to local regulatory elements driving ectopic expression.
Article
Biology
Colin J. Dinsmore, Philippe Soriano
Summary: Serum response factor (SRF) is a crucial transcription factor that regulates various cellular processes. It controls the expression of immediate early genes and actin cytoskeleton-related genes, which are involved in cell proliferation, migration, and differentiation. SRF coordinates these processes through the interaction with its cofactors, ternary complex factors (TCFs) and myocardin-related transcription factors (MRTFs). This study demonstrates the important role of MRTFs in mediating SRF function during cardiac neural crest development, providing new insights into the transcriptional regulation mechanism of SRF during development.
Article
Developmental Biology
Ayan T. Ray, Philippe Soriano
Summary: Loss of FGF signaling leads to defects in salivary gland branching. Disruption of Fgfr1 and Fgfr2 expression in salivary gland epithelial cells reveals their coordinated function in regulating branching. Non-canonical FGF signaling mechanisms involving cell-cell and cell-matrix adhesion play a role in salivary gland branching morphogenesis.
Article
Biology
James F. Clark, Philippe Soriano
Summary: FGF activation engages canonical signals through various effectors, including FRS2 and GRB2. However, the interaction between GRB2 and FGFR2 is not required for development or adult homeostasis. Mutant mice lacking the C-terminal end of FGFR2 showed no distinguishable phenotype, indicating that GRB2 binding to FGFR2 is not critical for development or homeostasis.
Article
Cell Biology
Ayan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe Soriano
GENES & DEVELOPMENT
(2020)
Article
Developmental Biology
Fenglei He, Philippe Soriano
Article
Cell Biology
Andrei Molotkov, Pierre Mazot, J. Richard Brewer, Ryan M. Cinalli, Philippe Soriano
DEVELOPMENTAL CELL
(2017)