期刊
NEUROENDOCRINOLOGY
卷 101, 期 1, 页码 82-86出版社
KARGER
DOI: 10.1159/000371803
关键词
Current depressive episode; Unipolar depression; Bipolar depression; Leptin
资金
- CNPq
- CAPES
- FAPERGS, Brazil
Objective: The present study investigated whether peripheral leptin levels are associated with current depressive episodes in a cross-sectional study nested within a population-based study. Methods: The Mini-International Neuropsychiatric Interview (MINI) 5.0 was used to assess the presence of current depressive episodes. The sample was composed of 206 subjects (103 controls and 103 subjects with a current depressive episode) paired by gender, BMI and age. Medication use and lifestyle characteristics were self-reported. Results: Serum leptin levels were lower in currently depressive subjects (10.9 +/- 12.0 ng/ml) than in the control group (20.3 +/- 24.0 ng/ml; p = 0.023). According to the clinical diagnosis, individuals with bipolar depression present lower leptin levels (8.4 +/- 8.1 ng/ml) than those with unipolar depression (12.0 +/- 13.4 ng/ml) and the control group (20.3 +/- 24.0 ng/ml; p = 0.031). In addition, ANCOVA showed that leptin is an independent factor associated with current depressive episodes (p = 0.018). Conclusion: A decreased leptin level might be a useful peripheral marker associated with depressive episodes in the context of bipolar disorder. (C) 2015 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据