Article
Biochemistry & Molecular Biology
Enrique Alfaro, Pablo Lopez-Jimenez, Jose Gonzalez-Martinez, Marcos Malumbres, Jose A. Suja, Rocio Gomez
Summary: The study reveals that during meiotic divisions in male mice, centrosomes duplicate twice to form bipolar spindles, with Polo-like kinase 1 playing a central role in centrosome assembly, maturation, migration, and spindle formation during spermatogenesis. Inhibition of both Polo-like kinase 1 and Aurora A in organotypic cultures of seminiferous tubules highlights their prominent role in regulating the formation of meiotic bipolar spindles.
Article
Biochemistry & Molecular Biology
Kathryn E. Neville, Tara M. Finegan, Nicholas Lowe, Philip M. Bellomio, Daxiang Na, Dan T. Bergstralh
Summary: In addition to Pins localization, interaction between Pins and Discs large is also required for spindle orientation in some cells.
Article
Multidisciplinary Sciences
Kalpana Jain, Sofia Lavista-Llanos, Veit Grabe, Bill S. Hansson, Dieter Wicher
Summary: The point mutation K339N in the Orco protein of fruit flies was found to reduce olfactory responses and impair odor localization performance. The mutation also eliminated the sensitization of olfactory sensory neurons to repeated weak odor stimuli.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Saheli Sengupta, Yick-Bun Chan, Caroline B. Palavicino-Maggio, Edward A. Kravitz
Summary: The role of mAL neurons in regulating aggression in fruit flies is characterized. Activation of mAL neurons increases aggression, while inactivation decreases aggression and increases intermale courtship. A small group of GABA+ central brain neurons with anatomical similarities to mAL is also found to be crucial for increasing intermale aggression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Pablo Guzman-Palma, Esteban G. Contreras, Natalia Mora, Macarena Smith, M. Constanza Gonzalez-Ramirez, Jorge M. Campusano, Jimena Sierralta, Bassem A. Hassan, Carlos Oliva
Summary: The Slit-Robo pathway is involved in the development of motion sensitive neurons in the Drosophila visual system, regulating processes such as neuronal precursor migration, cell segregation, and connectivity pattern formation. This signaling pathway plays a versatile role in different developmental stages of a neural lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pedro Prudencio, Rosina Savisaar, Kenny Rebelo, Rui Goncalo Martinho, Maria Carmo-Fonseca
Summary: This study used NET-seq technology to measure the cotranscriptional splicing dynamics during the early developmental stages of Drosophila embryos. The results revealed the position of RNA polymerase II during splicing and found heterogeneity in splicing dynamics. The study also observed the relationship between intron size and spliced reads, as well as the differences in gene transcription patterns between early and later embryonic development.
Article
Cell Biology
Ojas Deshpande, Jorge De-Carvalho, Diana V. Vieira, Ivo A. Telley
Summary: This study highlights the essential role of Feo and Klp3A in the distribution and maintenance of nuclear internuclear distance in Drosophila embryos through cross-linking of microtubules. Disruption of this cross-linking mechanism leads to irregular nuclear delivery and smaller distribution in the embryos. The dimerization activity of Feo is crucial for maintaining proper nuclear separation and distance in the embryo.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Cell Biology
T. Ferreira Luisa, Helder Maiato
Summary: Accurate chromosome segregation during mitosis requires a complete restructuring of cellular organization, including the remodeling of microtubules and actin cytoskeleton. These cytoplasmic events must be coordinated with mitotic chromosome condensation and nuclear envelope permeabilization to ensure mitotic timing and fidelity. Recent progress has been made in understanding the regulatory biochemical and mechanical pathways involved in these processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Minwoo Baek, Wijeong Jang, Changsoo Kim
Summary: This study identifies dual oxidase (duox) as a source of neuronal oxidative stress associated with animal lifespan. The research found that reducing oxidative stress in neurons extends the lifespan of Drosophila melanogaster, with duox playing a crucial role in this process.
Article
Cell Biology
Sandro M. Meier, Ana-Maria Farcas, Anil Kumar, Mahdiye Ijavi, Robert T. Bill, Joerg Stelling, Eric R. Dufresne, Michel O. Steinmetz, Yves Barral
Summary: This study investigates the interactions and functions of the Kar9 network in yeast cells, finding that it forms a liquid condensate at selected microtubule ends, serving as a mechanical coupling between microtubules and actin cables.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
George P. Kapali, Viviane Callier, Samuel J. L. Gascoigne, Jon F. Harrison, Alexander W. Shingleton
Summary: In fruit flies, the steroid hormone ecdysone regulates growth and body size development under hypoxic conditions by suppressing the insulin/IGF-signaling pathway. This suggests the existence of growth-regulatory mechanisms that respond to general environmental perturbation rather than individual environmental factors.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin
Summary: Alterations in the neuromuscular system contribute to various diseases and aging-related muscle loss. This study identifies Plum as a modulator of MYO function in the neuromuscular system and reveals its role in regulating muscle size and synaptic function.
Article
Cell Biology
Fabiola Mascanzoni, Roberta Iannitti, Antonino Colanzi
Summary: The dynamic association between the Golgi complex and the centrosome plays a crucial role in cellular processes such as cell polarization and division.
Article
Biology
Nilay Nandi, Zuhair Zaidi, Charles Tracy, Helmut Kramer
Summary: This study identified the mechanisms regulating neuronal autophagy. It was found that the PPM-type phosphatase Nil counterbalances the phosphorylation of Acinus-serine(437) and controls the level of neuronal autophagy. It was also discovered that exposure to Cd2+ increases the phosphorylation of Acinus-serine(437), leading to increased autophagy and protection against Cd2+-induced cytotoxicity.
Article
Multidisciplinary Sciences
Baojian Chen, Lena Maas, Duarte Figueiredo, Yu Zhong, Ricardo Reis, Mengran Li, Anneke Horstman, Tjitske Riksen, Mieke Weemen, Hang Liu, Charlotte Siemons, Shaojiang Chen, Gerco C. Angenent, Kim Boutilier
Summary: The BBM transcription factor plays a major role in plant cell totipotency and seed development. This study reexamined the expression and function of BBM in Arabidopsis, and identified its crucial roles in the timing of embryo progression and the maintenance of zygotic embryo development. The study also demonstrated the engineering potential of BBM genes for asexual embryo development in dicot species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Mohammad KaramiNejadRanjbar, Sahand Sharifzadeh, Nina C. Wietek, Mara Artibani, Salma El-Sahhar, Tatjana Sauka-Spengler, Christopher Yau, Volker Tresp, Ahmed A. Ahmed
Article
Oncology
Zhiyuan Hu, Paula Cunnea, Zhe Zhong, Haonan Lu, Oloruntoba I. Osagie, Leticia Campo, Mara Artibani, Katherine Nixon, Jennifer Ploski, Laura Santana Gonzalez, Abdulkhaliq Alsaadi, Nina Wietek, Stephen Damato, Sunanda Dhar, Sarah P. Blagden, Christopher Yau, Joanna Hester, Ashwag Albukhari, Eric O. Aboagye, Christina Fotopoulou, Ahmed Ahmed
Summary: In this study, a 52-gene NanoString panel was developed to validate the robustness of the OxC classifier for serous ovarian cancers (SOCs). The results revealed that EMT-high SOCs have a particularly poor prognosis, independent of established clinical parameters, and are associated with a high frequency of immunosuppressive macrophages, suggesting a potential therapeutic target to improve clinical outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Psychology, Clinical
Sarah Elison-Davies, Kaspar Martens, Christopher Yau, Glyn Davies, Jonathan Ward
Summary: CAT may reduce opioid use and improve biopsychosocial functioning in individuals with OUD, with those participants with greater baseline clinical impairment demonstrating a greater magnitude of improvement from baseline to post-treatment.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2021)
Article
Genetics & Heredity
Joel Nulsen, Hrvoje Misetic, Christopher Yau, Francesca D. Ciccarelli
Summary: sysSVM2 is a machine learning software that integrates cancer genetic alterations with gene systems-level properties to predict driver genes in individual patients, showing low false-positive rate and stability, with applicability to rare cancer types. It can be used to identify driver alterations in patients lacking sufficient canonical drivers, furthering the goals of precision oncology.
Review
Oncology
Matteo Morotti, Ashwag Albukhari, Abdulkhaliq Alsaadi, Mara Artibani, James D. Brenton, Stuart M. Curbishley, Tao Dong, Michael L. Dustin, Zhiyuan Hu, Nicholas McGranahan, Martin L. Miller, Laura Santana-Gonzalez, Leonard W. Seymour, Tingyan Shi, Peter Van Loo, Christopher Yau, Helen White, Nina Wietek, David N. Church, David C. Wedge, Ahmed A. Ahmed
Summary: Cancer remains a leading cause of death globally, with metastatic disease posing challenges even with advancements in targeted therapies and immunotherapies. Adoptive T-cell therapy has shown promise in providing durable responses and potential cures for cancer patients. Advancements in genomics, immunology, and cell manufacturing are bringing personalized therapies for cancer patients closer to reality, challenging traditional standards of care and offering opportunities for a paradigm shift in cancer therapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Siang Ing Lee, Amaya Azcoaga-Lorenzo, Utkarsh Agrawal, Jonathan Kennedy, Adeniyi Francis Fagbamigbe, Holly Hope, Anuradhaa Subramanian, Astha Anand, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Francesca Crowe, Gillian Santorelli, Kelly-Ann Eastwood, Zoe Vowles, Maria Loane, Ngawai Moss, Peter Brocklehurst, Rachel Plachcinski, Shakila Thangaratinam, Mairead Black, Dermot O'Reilly, Kathryn M. Abel, Sinead Brophy, Krishnarajah Nirantharakumar, Colin McCowan
Summary: This study investigated the prevalence of pre-existing multimorbidity in pregnant women in the United Kingdom and found that it is a common occurrence. The study also identified older age, multiple pregnancies, higher body mass index, and preconception smoking as factors associated with a higher risk of multimorbidity in pregnant women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Astha Anand, Beck Taylor, Catherine Nelson-Piercy, Christopher Yau, Colin McCowan, Dermot O'Reilly, Holly Hope, Jonathan Ian Kennedy, Kathryn Mary Abel, Louise Locock, Peter Brocklehurst, Rachel Plachcinski, Sinead Brophy, Utkarsh Agrawal, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black
Summary: This study aims to develop a core outcome set for maternal and offspring outcomes in pregnant women with pre-existing multimorbidity. The study design includes systematic literature search, focus groups, Delphi surveys, and consensus group meetings, intended for broad application in various pregnancy settings.
Article
Oncology
Kasun Wanigasooriya, Joao D. Barros-Silva, Louise Tee, Mohammed E. El-asrag, Agata Stodolna, Oliver J. Pickles, Joanne Stockton, Claire Bryer, Rachel Hoare, Celina M. Whalley, Robert Tyler, Toritseju Sillo, Christopher Yau, Tariq Ismail, Andrew D. Beggs
Summary: This study investigates the mechanisms of resistance to chemoradiotherapy in rectal cancer using patient derived organoid models. The upregulation of PI3K/AKT/mTOR pathway is found to contribute to radioresistance, and its targeted pharmacological inhibition leads to significant improvement in cancer cell sensitivity to radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Siang Ing Lee, Holly Hope, Dermot O'Reilly, Lisa Kent, Gillian Santorelli, Anuradhaa Subramanian, Ngawai Moss, Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Catherine Nelson-Piercy, Christopher Yau, Colin McCowan, Jonathan Ian Kennedy, Katherine Phillips, Megha Singh, Mohamed Mhereeg, Neil Cockburn, Peter Brocklehurst, Rachel Plachcinski, Richard D. Riley, Shakila Thangaratinam, Sinead Brophy, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Utkarsh Agrawal, Zoe Vowles, Kathryn Mary Abel, Krishnarajah Nirantharakumar, Mairead Black, Kelly-Ann Eastwood, MuM PreDiCT
Summary: This observational study aims to compare maternal and child outcomes for pregnant women with multiple long-term conditions to those without multiple long-term conditions. Data from routine health records in the UK and the Born in Bradford birth cohort will be used to examine the association of multiple long-term conditions with various outcomes. The results will be published in peer-reviewed journals and presented at conferences.
Article
Biotechnology & Applied Microbiology
Zhiyuan Hu, Ahmed A. Ahmed, Christopher Yau
Summary: CIDER is a meta-clustering workflow based on inter-group similarity measures, which outperforms other methods in clustering single-cell RNA-Seq data and can be used to assess the biological correctness of integration without prior cellular annotations.
Correction
Multidisciplinary Sciences
Rens van de Schoot, Sarah Depaoli, Ruth King, Bianca Kramer, Kaspar Martens, Mahlet G. Tadesse, Marina Vannucci, Andrew Gelman, Duco Veen, Joukje Willemsen, Christopher Yau
Summary: The paper has been corrected.
NATURE REVIEWS METHODS PRIMERS
(2021)
Review
Multidisciplinary Sciences
Rens van de Schoot, Sarah Depaoli, Ruth King, Bianca Kramer, Kaspar Maertens, Mahlet C. Tadesse, Marina Vannucci, Andrew Gelman, Duco Veen, Joukje Willemsen, Christopher Yau
Summary: Bayesian statistics is a data analysis approach based on Bayes' theorem, which involves determining parameters through prior distributions, likelihood functions, and posterior distributions. This method has shown successful applications in various disciplines and has improved accuracy in predicting future events.
NATURE REVIEWS METHODS PRIMERS
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
Kaspar Martens, Christopher Yau
INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 108
(2020)
Proceedings Paper
Computer Science, Artificial Intelligence
Kaspar Martens, Christopher Yau
INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 108
(2020)
Meeting Abstract
Hematology
D. Murray, S. Eldershaw, H. Pearce, C. Yau, J. Scarisbrick, P. Moss
BRITISH JOURNAL OF HAEMATOLOGY
(2020)