Article
Medicine, General & Internal
Eder H. Cativo, Persio D. Lopez, Diana P. Cativo, Steven A. Atlas, Clive Rosendorff
Summary: This study found that inhibitors of the renin-angiotensin system are more effective than calcium channel blockers in reducing albuminuria in patients with nephropathy due to hypertension and diabetes mellitus. However, there was no significant difference between the two drug classes in terms of markers of renal function.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Peripheral Vascular Disease
Chien-Chang Lee, Meng-Tse Gabriel Lee, Wan-Ting Hsu, James Yeongjun Park, Lorenzo Porta, Michael A. Liu, Shyr-Chyr Chen, Shan-Chwen Chang
Summary: A nested case-control study using the National Health Insurance Research Database of Taiwan showed that the use of dihydropyridine CCBs is associated with a reduced risk of active tuberculosis. Subgroup analyses did not find significant differences in the risk of tuberculosis with CCB use among patients with heart failure or cerebrovascular diseases.
Review
Medicine, General & Internal
Roberto Manfredi, Monica Verdoia, Paolo Compagnucci, Alessandro Barbarossa, Giulia Stronati, Michela Casella, Antonio Dello Russo, Federico Guerra, Giuseppe Ciliberti
Summary: Angina is the main symptom of ischemic heart disease, which can be caused by both epicardial coronary stenoses and coronary vasomotor disorders. Antianginal medications have been proven effective in improving symptoms, quality of life, and prognosis, but should be tailored to individual patient history and potential drug interactions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Wei-Ting Chang, Sudeshna Fisch, Seema Dangwal, Michael Chen, Susan Cheng, Zhih-Cherng Chen, Ronglih Liao
Summary: Coronary flow velocity is decreased in pathologic cardiac hypertrophy, linked to angiotensin II. Angiotensin receptor blockers have been shown to improve CFV and cardiac function. This suggests a molecular and functional link between angiotensin-induced hemodynamic remodeling and coronary vasculature changes.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Brent M. Egan, Jianing Yang, Michael K. Rakotz, Susan E. Sutherland, Kenneth A. Jamerson, Jackson T. Wright, Keith C. Ferdinand, Gregory D. Wozniak
Summary: The study found that initial therapy with calcium channel blockers or thiazide-type diuretics had better antihypertensive effects in non-Hispanic Black adults than renin-angiotensin system blockers. Despite the recommendation to use this treatment approach, there is still a gap between the recommended and actual use. Evidence-based monotherapy appears insufficient to improve hypertension control in non-Hispanic Black adults.
Article
Immunology
Vignesh Chidambaram, Akshay Gupte, Jann-Yuan Wang, Jonathan E. Golub, Petros C. Karakousis
Summary: Patients with hypertension have increased all-cause mortality and infection-related mortality during the first 9 months following TB treatment initiation. The use of Dihydropyridine-CCB may lower all-cause mortality in TB patients with hypertension, but the presence of hypertension or the use of CCB does not significantly impact microbiological outcomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Peripheral Vascular Disease
Matthew C. Hyman, Michael G. Levin, Dipender Gill, Venexia M. Walker, Marios K. Georgakis, Neil M. Davies, Francis E. Marchlinski, Scott M. Damrauer
Summary: Genetic variants associated with higher blood pressure are linked to an increased risk of atrial fibrillation, suggesting a causal relationship between blood pressure and AF. Reduction of blood pressure with calcium channel blockers or beta-blockers may help lower the risk of AF.
Review
Chemistry, Analytical
Ayyappa Bathinapatla, Suvardhan Kanchi, Rajasekhar Chokkareddy, Reddy Prasad Puthalapattu, Mulpuri Ravi Kumar
Summary: Stress, ingrained human behaviors, inactive lifestyle, and poor dietary decisions are primary causes of hypertension and coronary artery disease. High blood pressure treatment using fi-blockers and calcium channel blockers is effective. Electrochemical sensors provide multiple benefits for detecting fi-blockers and CCBs, including sensitivity, selectivity, rapidity, and cost-effectiveness.
MICROCHEMICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Deniz Turkmen, Jane A. H. Masoli, Joao Delgado, Chia-Ling Kuo, Jack Bowden, David Melzer, Luke C. Pilling
Summary: This study aimed to investigate the association between reported pharmacogenetic variants and incident adverse events in patients prescribed dihydropyridine calcium-channel blockers (dCCBs). The results showed that carriers of the rs877087 T allele in RYR3 had an increased risk of heart failure. Additionally, genetic variants in NUMA1 and CYP3A5 were also associated with adverse clinical outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sheng Qi Xiao, Francisco Ibarra, Mallory Cruz
Summary: This study compared the efficacy and safety of IV metoprolol and diltiazem for rate control in AF, finding no significant difference in rate control achievement, time to rate control, or adverse events between the two medications. Patient-specific factors do not seem to influence the preference for one medication over the other.
ANNALS OF PHARMACOTHERAPY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Dimitrios Farmakis, Andrew Xanthopoulos, Filippos Triposkiadis
Summary: The traditional plaque-centric model of CAD pathophysiology and management has been questioned, leading to a paradigm shift considering the multifactorial aspect of CAD. An alternative medical management approach based on drug properties in relation to myocardial ischemia pathophysiology has been proposed for chronic CAD and stable angina patients, organized into disease-modifying therapy, pathophysiology-based anti-ischaemic therapy, and symptomatic therapy.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Review
Chemistry, Analytical
Suraj R. Chaudhari, Atul A. Shirkhedkar
Summary: This review article discusses crucial analytical methodologies for the pharmaceutical analysis of cilnidipine in various forms, including hyphenated techniques, high-performance thin-layer chromatography, high-performance liquid-chromatography, and other approaches. From the literature, it is concluded that high-performance liquid-chromatography and UV/Vis-spectrophotometry methods are the most commonly used for analyzing cilnidipine.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Dongze Zhang, Huiyin Tu, Chaojun Wang, Liang Cao, Wenfeng Hu, Bryan T. Hackfort, Robert L. Muelleman, Michael C. Wadman, Yu-Long Li
Summary: Cardiac sympathetic overactivation is associated with ventricular arrhythmias in CHF patients; investigating the role of Cav2.2 channels in CHF revealed that transfection with Cav2.2-alpha shRNA reduced expression of Cav2.2-alpha mRNA and protein, decreasing neuronal currents and excitability, improving sympathetic nerve activity, and reducing ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Steven Shea, Ana Navas-Acien, Daichi Shimbo, Elizabeth R. Brown, Matthew Budoff, Michael P. Bancks, R. Graham Barr, Richard Kronmal
Summary: The study found that the spatially weighted coronary calcium score (SWCS) can predict the likelihood of incident coronary heart disease events in individuals with a score of zero on the Agatston coronary artery calcium (CAC) score.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Review
Pediatrics
Nicola Bertazza Partigiani, Rachele Spagnol, Laura Di Michele, Micaela Santini, Benedetta Grotto, Alex Sartori, Elita Zamperetti, Margherita Nosadini, Davide Meneghesso
Summary: Hypertensive emergencies in pediatric patients are life-threatening conditions associated with severe hypertension and organ damage. Current guidelines for managing pediatric hypertensive emergencies are limited, with most of the evidence derived from adult studies. β-blockers appear to be safe and effective in hypertensive crises, while calcium-channel blockers, particularly clevidipine, show potential as effective and safe treatment options. However, further research is needed to establish a uniform approach to pediatric hypertensive emergencies.
FRONTIERS IN PEDIATRICS
(2022)