Article
Chemistry, Medicinal
Fernando Sabia Tallo, Patricia Oliveira de Santana, Sandra Augusta Gordinho Pinto, Rildo Yamaguti Lima, Erisvaldo Amarante de Araujo, Jose Gustavo Padrao Tavares, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Murched Omar Taha, Andre Ibrahim David, Braulio Luna-Filho, Carlos Eduardo Braga Filho, Adriano Henrique Pereira Barbosa, Celia Maria Camelo Silva, Almir Goncalves Wanderley, Adriano Caixeta, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Summary: Acute myocardial infarction is a major cause of morbidity and mortality worldwide, characterized by severe arrhythmias induced by cardiac ischemia/reperfusion. This study reveals that pharmacological modulation of the cardiac Ca2+/cAMP/adenosine signaling pathway could be a promising therapeutic strategy to reduce the incidence of severe and fatal arrhythmias caused by AMI.
Article
Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alice E. Zemljic-Harpf, Louise E. See Hoe, Jan M. Schilling, Juan P. Zuniga-Hertz, Alexander Nguyen, Yash J. Vaishnav, Gianna J. Belza, Boris P. Budiono, Piyush M. Patel, Brian P. Head, Wolfgang H. Dillmann, Sushil K. Mahata, Jason N. Peart, David M. Roth, John P. Headrick, Hemal H. Patel
Summary: The study demonstrates that morphine treatment can improve cardiac function and structure, enhance tolerance to ischemia-reperfusion injury, and potentially have translational value in diabetic patients.
Article
Biochemistry & Molecular Biology
Vicente Castrejon-Tellez, Leonardo del Valle-Mondragon, Israel Perez-Torres, Veronica Guarner-Lans, Gustavo Pastelin-Hernandez, Angelica Ruiz-Ramirez, Julieta Anabell Diaz-Juarez, Elvira Varela-Lopez, Victor Hugo Oidor-Chan, Alvaro Vargas-Gonzalez, Raul Martinez-Memije, Pedro Flores-Chavez, Bruno Leon-Ruiz, Sergio Arriaga-Carrillo, Juan Carlos Torres-Narvaez
Summary: TRPV1 activation regulates the NO pathway to counteract myocardial injury caused by ischemia-reperfusion.
Article
Cell Biology
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy
Summary: Mitophagy plays a crucial role in maintaining cardiac homeostasis by selectively eliminating dysfunctional mitochondria. It is mainly regulated by the PINK1/parkin pathway and also by the FUNDC1, BNIP3, and BNIP3L/NIX pathways. Dysregulated mitophagy is associated with cardiac dysfunction, while moderate mitophagy has a cardioprotective effect.
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Article
Pharmacology & Pharmacy
Mi Bao, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Fenfei Gao, Danmei Huang, Bin Wang, Ganggang Shi
Summary: The study demonstrated that verapamil reduces myocardial I/R-induced oxidative stress through modulation of SIRT1 signaling, resulting in decreased ROS and MDA levels, and subsequently protecting against cardiac dysfunction and myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Li Chen, Dazhuo Shi, Ming Guo
Summary: PKC-delta and PKC-epsilon play crucial roles in protecting the myocardium during ischemia/reperfusion injury through their involvement in redox regulation, cell death, Ca2+ overload, and mitochondrial dysfunction.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sandrine Lecour, Ioanna Andreadou, Hans Erik Botker, Sean M. Davidson, Gerd Heusch, Marisol Ruiz-Meana, Rainer Schulz, Coert J. Zuurbier, Peter Ferdinandy, Derek J. Hausenloy
Summary: The researchers proposed a set of standards called IMPACT to improve the evaluation of cardioprotective interventions before entering clinical studies, aiming to increase the likelihood of translating novel cardioprotective interventions into beneficial clinical practice for patients.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emily Sze-Wan Wong, Renkai Li, Jingjing Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Sai-Wang Seto, George Pak-Heng Leung
Summary: This study investigated the involvement of equilibrative nucleoside transporter 4 (ENT4) in adenosine transport in cardiomyocytes under simulated ischemic conditions. The results showed that inhibition of ENT4 could protect cardiomyocytes against ischemia-reperfusion injury. These findings suggest that ENT4 may play a role in adenosine transport in cardiomyocytes under ischemic conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Eman Gouda, Fawzi Babiker
Summary: This study investigated the antioxidant and anti-inflammatory effects of Gum Arabic in protecting the heart against ischemia/reperfusion injury. The results showed that GA significantly reduced infarct size and cardiac enzyme levels, and decreased pro-inflammatory cytokine levels.
SCIENTIFIC REPORTS
(2022)